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Mitolyn Weight Loss Update My Mitolyn Review Mitolyn SupplementDrs Akshay Jain and Girish Joshi discuss clinical considerations to keep in mind when someone on GLP-1 therapy is undergoing elective procedures. https://www.medscape.com/viewarticle/glp-1-guidance-reduce-regurgitation-and-aspiration-risk-2024a1000d35?src=soc_yt -- TRANSCRIPT -- Akshay B. Jain, MD: Welcome back to ADA 2024 updates. I'm endocrinologist Dr Akshay Jain from Vancouver in Canada, and today we've got a very special guest. We've got Professor Dr Girish Joshi. Dr Joshi is a professor of anesthesiology and pain medicine at UT Southwestern in Dallas, Texas. He was one of the speakers at a very impactful session that was talking about the postoperative and intraoperative considerations for people who are on GLP-1 therapy. He's here to talk with us about clinical considerations that one needs to keep in mind when someone on glucagon-like peptide 1 (GLP-1) receptor agonist therapy is undergoing elective procedures. Welcome, Dr Joshi. Girish P. Joshi, MD: Thank you, Akshay. It's an honor. Jain: I was attending your session, and I found it very clinically impactful. This is something that we are seeing more and more in clinical practice. For our viewers today, can you share with us, as an anesthesiologist, the potential risks for aspiration and the rates of aspiration that you're seeing in people who are on GLP-1 therapy? Joshi: We don't know the exact rate of aspiration with GLP-1 therapy because there are no good studies, but there are several anecdotal reports, including several personal communications where people have contacted me and the American Society of Anesthesiologists (ASA). I'm the chair of the task force for these GLP-1 recommendations developed by the ASA. To give an example, one of the cases reported to me was from a colleague in Dallas where a patient, otherwise completely healthy, came in for a shoulder arthroscopy — a simple outpatient procedure in a freestanding ambulatory surgery center. Surgery went fine. At the end of the procedure, she regurgitated gastric content and aspirated, and then had to be taken to the intensive care unit (ICU) and she spent 7 days in the ICU. Retrospectively, it was recognized that she was on GLP-1 therapy for weight loss, which was not disclosed. This was just before the ASA came up with the guidance, basically, so people didn't know that GLP-1 receptor agonists do increase the risk for aspiration. Jain: That's a really good point straight from your clinical practice. For our viewers who may not be familiar with the guidelines, could you tell us, in a nutshell, for people on GLP-1 therapy who are going in for an elective procedure that requires general anesthesia, what would be the recommendations for holding GLP-1s? Joshi: I have to first emphasize that currently, the evidence to provide any guidance is sparse, and whatever studies are available are basically questionable or of poor quality. With that said, the reason why the ASA came up with the guidance was to inform our colleagues, anesthesiologists, as well as our colleagues from surgery and other proceduralists of this concern about increased regurgitation and aspiration in patients on GLP-1 receptor agonists. That was the primary aim. Because the evidence is sparse, we basically came up with different approaches to decrease or mitigate the risk for regurgitation and aspiration. It starts with having a collaborative discussion, including the patients, or shared decision-making with the physicians and the patient regarding the potential risks, so mention to the patient that there is a potential risk. Then, avoid the elective procedures in patients at high risk. Examples of patients at high risk would be those who are basically in the escalation phase of the GLP-1 therapy, patients with prior history of gastroparesis, or patients on drugs that can cause gastroparesis. I don't know whether you remember I had an algorithm I developed and presented at the American Diabetes Association (ADA) meeting, where I presented the potential risk factors. If the patients are at risk for regurgitation and aspiration, that's the patient population we've got to be extra careful with. Maybe start off withholding the drug if the patients are on, say, a weekly therapy, then 1 week before, though the evidence is minimal. 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Here are the foods and supplements research shows might work - and don't work. ➡️ Watch These Videos Too https://youtu.be/qRN54kQgjvQ https://youtu.be/eOmhP7WzJcg https://youtu.be/b54XNw_-eI4 https://youtu.be/-ElofEeEuHA https://youtu.be/XoSZcg2E0s4 https://youtu.be/66kDO86j8BM https://youtu.be/ONN_1DCgRWE ➡️ Things I like & use: Aged garlic extract https://amzn.to/2LP3tlr Best Blender on Earth https://amzn.to/2ypgzxa Best Juicer on Earth https://amzn.to/2LR1BIW References https://pubmed.ncbi.nlm.nih.gov/26084343/ https://pubmed.ncbi.nlm.nih.gov/29920323/ https://pubmed.ncbi.nlm.nih.gov/20147463/ https://pubmed.ncbi.nlm.nih.gov/31968119/ https://pubmed.ncbi.nlm.nih.gov/32869813/ https://pubmed.ncbi.nlm.nih.gov/18796545/ https://pubmed.ncbi.nlm.nih.gov/30558330/ https://pubmed.ncbi.nlm.nih.gov/32183423/ https://pubmed.ncbi.nlm.nih.gov/17593904/ https://pubmed.ncbi.nlm.nih.gov/35135006/ https://pubmed.ncbi.nlm.nih.gov/32713353/ https://pubmed.ncbi.nlm.nih.gov/24993695/ https://pubmed.ncbi.nlm.nih.gov/25125505/ https://pubmed.ncbi.nlm.nih.gov/21489570/ https://pubmed.ncbi.nlm.nih.gov/12600850/ https://pubmed.ncbi.nlm.nih.gov/34684407/ https://pubmed.ncbi.nlm.nih.gov/24614112/ https://pubmed.ncbi.nlm.nih.gov/23964154/ https://www.semanticscholar.org/paper/Yerba-mate-may-prevent-diabetes-according-to-a-in-Sarri%C3%A1-Mart%C3%ADnez-L%C3%B3pez/d74daaad255284c1982f52ea00972881f8ac75aa https://pubmed.ncbi.nlm.nih.gov/19695149/ https://pubmed.ncbi.nlm.nih.gov/38351702/ ➡️ Things used to make this video: 1 Lot’s of work 2 This video editing software: https://amzn.to/2V7sr28 3 This Microphone: https://amzn.to/2RslCFH 4 This computer: https://amzn.to/3ZkViyR ➡️My websites: https://joe-cannon.com/ https://supplementclarity.com/ My books: https://amzn.to/2L3tOLc Disclaimer ⚠️ ➡️ I’m NOT a doctor, pharmacist, or dietitian. I hold an MS degree in exercise science and a BS degree in chemistry and biology. Videos are for general information only. No medical advice is given or implied. Do not use these videos to diagnose or treat yourself. Always seek the advice of a physician or other qualified health provider when you have questions about your health and medical conditions. While reasonable care is used to compile the information, mistakes can still be made. No warranty is made as to its accuracy. As an Amazon Associate, I earn from qualifying purchases. #GLP1 #supplementclarity #glp1forweightlossSumatra Slim Belly Tonic Works Oriental Blue Tonic Recipe Complete Review For Weight Loss Abnehmen Pillen sind bei vielen Menschen beliebt, die schnell und einfach Gewicht verlieren möchten. Diese Pillen versprechen oft eine schnelle und effektive Gewichtsabnahme ohne viel Aufwand. Doch wie effektiv sind sie wirklich und welche Risiken bergen sie? In diesem Artikel bieten wir einen Überblick über die Effektivität und Risiken von Abnehmen Pillen. Was sind Abnehmen Pillen? Abnehmen Pillen, auch bekannt als Diätpillen oder Schlankheitspillen, sind Nahrungsergänzungsmittel, die entwickelt wurden, um beim Abnehmen zu helfen. Sie enthalten oft Wirkstoffe wie Appetitzügler, Fettblocker oder Stoffe, die den Stoffwechsel anregen sollen. Diese Substanzen sollen den Gewichtsverlust fördern, indem sie den Appetit reduzieren, die Fettverbrennung steigern oder die Aufnahme von Fett blockieren. Allerdings sollte beachtet werden, dass Abnehmen Pillen allein keine Wundermittel sind und in Kombination mit einer ausgewogenen Ernährung und regelmäßiger Bewegung verwendet werden sollten, um effektive Ergebnisse zu erzielen. Es ist wichtig, sich vor der Einnahme von Abnehmen Pillen ausführlich zu informieren und im Zweifelsfall einen Arzt oder Ernährungsberater zu konsultieren. Effektivität von Abnehmen Pillen Die Effektivität von Abnehmen Pillen ist oft umstritten, da viele Produkte nicht ausreichend wissenschaftlich getestet sind. Einige Studien legen nahe, dass bestimmte Inhaltsstoffe in Abnehmen Pillen tatsächlich beim Gewichtsverlust helfen können, während andere keine signifikanten Ergebnisse zeigen. Es ist wichtig, kritisch zu hinterfragen, ob die beworbenen Effekte tatsächlich nachgewiesen sind und ob mögliche Nebenwirkungen in Kauf genommen werden sollten. Es ist ratsam, sich vor dem Kauf von Abnehmen Pillen über mögliche Risiken und die tatsächliche Wirksamkeit zu informieren. Manche Produkte können unerwünschte Nebenwirkungen wie Magenbeschwerden, Kopfschmerzen oder Schlafstörungen verursachen. Zudem können Abnehmen Pillen in Kombination mit Medikamenten oder bestimmten Vorerkrankungen gesundheitsschädlich sein. Risiken von Abnehmen Pillen Abnehmen Pillen bergen verschiedene Risiken, die nicht außer Acht gelassen werden sollten. Einige Produkte enthalten möglicherweise gefährliche Substanzen oder sind nicht ausreichend auf ihre Sicherheit getestet. Es kann zu unerwünschten Nebenwirkungen wie Herzrasen, Bluthochdruck oder Nierenproblemen kommen. Es ist wichtig, qualitativ hochwertige Abnehmen Pillen von seriösen Herstellern zu wählen und sich vor der Einnahme über mögliche Risiken zu informieren. Auch eine ausgewogene Ernährung und regelmäßige Bewegung sollten nicht vernachlässigt werden, um langfristig und gesund Gewicht zu verlieren. Fazit Abnehmen Pillen können eine Option sein, um beim Gewichtsverlust zu unterstützen, sollten jedoch mit Vorsicht und Bedacht eingenommen werden. Es ist wichtig, sich über die Effektivität und Risiken von Abnehmen Pillen zu informieren und im Zweifelsfall professionelle Beratung einzuholen. Letztendlich sollte der Fokus auf einer gesunden Lebensweise mit ausgewogener Ernährung und ausreichend Bewegung liegen, um langfristige Erfolge beim Abnehmen zu erzielen. 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