Transcript Janelle Brown Weight Loss The Inspiring 100 Pound Transformation Journey Of 2024this is not a promotional video... only for education "Fat burn karna hai fast? Yeh supplement helping karega aapko belly fat reduce karne mein aur metabolism boost karne mein! India ke best fat burner options ke baare mein jaaniye is short video mein. Perfect for men & women jo chahte hain quick fat loss results. Disclaimer: Har supplement sabke liye kaam nahi karta. Doctor ya nutritionist se consult zaroor karein before use. Like, Share & Subscribe for more Tips! #FatBurnerIndia #WeightLossJourney #DesiFitness #FatLossTips #SupplementsThatWork" #FatBurnerIndia #WeightLossSupplement #DesiFitness #FatLossTips #IndianSupplements #BurnFatFast #HinglishShorts #FitnessIndia #SupplementsThatWork #FatToFitVera Journey Through Weight Loss And Hip ReplacementFuel Your Mounjaro Weight Loss Journey with This High-Protein Smoothie! Looking for a delicious, high-protein smoothie to support your Manjaro or weight loss journey? This easy, nutritious, and satisfying smoothie is a game changer and perfect for keeping you full, energized, and on track with your goals! If you're taking Mounjaro (tirzepatide) or on a weight loss journey and looking for a quick, easy, and delicious way to boost your protein intake, stay full, and support your weight loss goals, then this recipe is for you! Packed with muscle-building protein, healthy fats, and essential nutrients, this smoothie is great for meal replacement, post-workout recovery, or a quick breakfast. Plus, it’s budget-friendly and easy to make at home! 📌 In This Video: ✅ My go-to high-protein smoothie recipe ✅ Mounjaro-friendly weight loss smoothie tips ✅ Low-carb, high-protein ingredients to stay full longer ✅ Budget-friendly meal ideas for healthy eating 💬 What’s your favorite high-protein smoothie ingredient? Let me know in the comments! 🔔 LIKE & SUBSCRIBE for more Mounjaro weight loss tips, budget-friendly recipes, and healthy meal ideas! SUBSCRIBE HERE: https://www.youtube.com/@TimeOutWithAngela AMAZON PRODUCTS: Protein Powder: https://amzn.to/3FSR3WX Sea Moss: https://amzn.to/3FSR3WX Moringa Powder: https://amzn.to/3FSR3WX UP NEXT: Check out another channel video here: https://www.youtube.com/watch?v=7knS5GwMXZA&list=PLpCCmnWN2QBMrBg-Gh2Us6LAk9MjdJQZF LET'S STAY CONNECTED: Don't forget to Like, Comment, Subscribe and hit the notification bell for more inspiring content around lidl shopping haul, aldi haul, uk grocery shopping haul, fashion try on, temu gardening, chaos gardening, mounjaro 5mg reviews, mounjaro vlog, work and travel, primark, primark haul, frugal rules and my spring garden FOLLOW ME ON SOCIALS: https://www.tiktok.com/@timeoutwithangela https://www.instagram.com/timeoutwithangela/ https://www.facebook.com/profile.php?id=61555882736932 #MounjaroWeightLoss #ProteinSmoothie #HomemadeProteinShake #WeightLossRecipe #MounjaroJourney #Tirzepatide #HealthySmoothie #EasyWeightLossRecipe #UKWeightLoss #HighProteinSmoothie #WeightLossSmoothie #HealthyEating #MealReplacement #LowCarbSmoothie #BudgetHealthyEating #TimeOutWithAngela #FrugalLiving #healthyrecipes DISCLAIMER: I am sharing my personal experience and this recipe is not intended as medical advice. 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• Tirzepatide、Semaglutide、Liraglutide 怎麼選?療效與副作用比較一次看懂 • 台灣健保給付限制、仿單外使用、心腎保護證據,全方位解析臨床現況 — 🔍內容解析: 本集重點: GLP-1受體促效劑(Glucagon-like peptide-1 receptor agonists, GLP-1 RAs)是目前糖尿病與肥胖症領域中最受矚目的藥物類別之一。這類藥物最初設計目的是控制第二型糖尿病血糖,但其延緩胃排空與降低食慾的機制,逐漸展現出優異的體重控制效果,成為減重治療的重要選項。 本集將全面比較目前臨床上常見的 GLP-1 RAs,包括 Semaglutide、Liraglutide、Dulaglutide、Exenatide、Tirzepatide 等,從作用機制、臨床療效、安全性,到心腎保護與健保給付現況,帶你掌握這波醫藥創新的核心。 — 🧩主題分段解析: — 🧬 GLP-1作用機轉:多重代謝效應的關鍵介質 GLP-1 是人體腸道於進食後釋放的一種腸泌素,具有多重生理功能: • 刺激胰島素分泌(在高血糖狀態下) • 抑制昇糖素分泌 • 延緩胃排空,增加飽足感 • 對中樞神經產生抑制食慾作用 GLP-1受體促效劑則是模擬這一生理訊號的藥物。由於天然 GLP-1 在體內迅速被 DPP-4 分解,因此這類藥物皆經修飾以延長半衰期,使其可每日或每週注射。 ⸻ 🩺 臨床療效比較:控糖與體重減輕雙重奏 根據大型隨機試驗與統合分析,GLP-1 RAs 在控制血糖(HbA1c)與體重管理上皆展現出顯著成效。 📌 各藥物臨床成效對比: 藥物名稱 HbA1c 降幅 體重減輕效果 使用頻率 核准適應症 Semaglutide -1.4 ~ -1.9% -6~15% 每週1次 第2型糖尿病、肥胖(國際核准) Tirzepatide -2.0 ~ -2.4% -10~20% 每週1次 第2型糖尿病(減重待核准) Liraglutide -1.0 ~ -1.5% -5~8% 每日1次 糖尿病、肥胖(Saxenda商品名) Dulaglutide -0.7 ~ -1.5% -2~5% 每週1次 糖尿病 Exenatide -0.8 ~ -1.0% -2~3% 每週或每日 糖尿病 其中 Tirzepatide 屬於 GIP/GLP-1 雙重受體促效劑,在 SURMOUNT 與 SURPASS 試驗中展現出前所未有的血糖控制與減重表現,有望改寫治療標準。 — 💖 心血管與腎臟保護:超越控糖的新方向 越來越多研究指出,GLP-1 RAs 除了降血糖與減重,也具有心腎保護效果,這點在糖尿病病人族群中特別重要。 📌 心血管研究亮點: • LEADER試驗(Liraglutide): 減少 MACE(重大心血管事件)13% • SUSTAIN-6(Semaglutide): 顯著降低心血管事件與腎功能惡化風險 • REWIND(Dulaglutide): 在高風險群中降低中風與心臟衰竭住院率 腎臟方面,GLP-1 RAs 可延緩 eGFR 下降速度、降低蛋白尿發生,與 SGLT2i 一同被納入 CKD 病患用藥建議中(KDIGO 2022)。 — ⚠️ 常見副作用與風險考量 GLP-1 類藥物最常見的不良反應是胃腸道不適: • 噁心、嘔吐、腹瀉(劑量上升時尤明顯) • 厭食、味覺改變 此外,也需注意以下安全議題: 1. 胰臟炎風險: 少見但需警惕,特別是胰臟病史者 2. 甲狀腺 C 細胞腫瘤: 動物實驗有顯示,故有甲狀腺腫瘤病史者應避免使用 3. 低血糖風險: 單用風險低,但與 SU 類或胰島素併用時需留意 4. 腎功能不全: 輕中度 CKD 可使用,但末期腎病需個別評估 目前各大指引皆建議以「緩慢劑量上升」的方式起始治療,以改善耐受性。 — 📋 台灣市場與健保現況:法規限制與臨床建議 雖然 GLP-1 RAs 在國際間已被廣泛應用於肥胖與代謝症候群治療,但在台灣市場仍受到幾項限制: 1. 健保給付範圍有限: 僅核准用於第二型糖尿病患者,且常須 HbA1c > 7.5% 且合併肥胖者 2. 體重管理為仿單外使用: 減重用途目前無正式健保核准 3. 高藥價問題: 自費族群常成經濟負擔障礙 4. 專科醫師使用限制: 多數藥品須由內分泌科或新陳代謝科開立 根據 NHIA 公告,目前 Semaglutide(Ozempic)與 Liraglutide(Victoza)皆列為給付藥品,但需符合嚴格條件。 — 🚶♀️ 臨床應用建議:如何選擇最適合的 GLP-1 受體促效劑? 臨床選擇應考慮以下因素: • 目標: 控糖為主或減重為主? • 用藥頻率接受度: 每日注射 vs 每週注射 • 腎功能狀況 • 副作用耐受性 • 病患偏好與經濟狀況 📌舉例: • 對減重有高度期待者:Tirzepatide > Semaglutide > Liraglutide • CKD早期患者:Semaglutide、Dulaglutide皆可考慮 • 容易噁心者:可考慮低劑量起始且選擇耐受性較佳者如 Dulaglutide • 自費負擔有限者:評估 Liraglutide 台灣仿單內使用是否適用 — 📣負責任的行動: GLP-1 受體促效劑不只是「減重神藥」,而是結合代謝改善、心腎保護與控糖成效的複合型療法。醫師在使用前應評估患者整體代謝風險、心血管病史與用藥習慣,避免將此藥物視為「萬靈丹」。 病患亦應接受完整衛教,了解可能副作用與正確使用方法,避免自行停藥或過度依賴。 — 📚熱門關鍵字: #GLP1受體促效劑 #Semaglutide #Ozempic #Tirzepatide #Mounjaro #Liraglutide #Saxenda #減重藥物 #糖尿病治療 #心血管保護 #腎臟保護 #胰島素促進劑 #胃排空延緩 #體重管理 #胃腸道副作用 #甲狀腺C細胞腫瘤 #台灣健保給付 #仿單外使用 #慢性腎病新療法 #糖尿病臨床指引 — 🎤主講人資訊: Dr.Happy Human Plumber|心血管知識推廣者 擅長將複雜代謝藥物與心腎內科整合知識,轉化為清晰易懂的內容,關注台灣臨床處方趨勢與全球新藥發展,致力於提升醫病雙方的治療選擇品質。 Powered by Firstory Hosting (https://firstory.me/zh)Dupatta Exercise For Belly Fatloss Improve Digestion Exercise Weightloss Shorts Trending Ketosium XS ACV Gummies 500mg are one of the latest products from Ketosium, a leading health and wellness company known for its innovative and high-quality supplements. 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I am an overweight pharmacist, I will NEVER use Ozempic for WEIGHT LOSS. https://youtu.be/P5pclzPFoZs ------------------------------- Source References: GoodRx: Ozempic https://www.goodrx.com/ozempic GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes https://www.nature.com/articles/nrneph.2017.123 Cardiovascular effects of Glucagon-like peptide 1 (GLP-1) receptor agonists https://cardiab.biomedcentral.com/articles/10.1186/s12933-014-0142-7 Contribution of gastroenteropancreatic appetite hormones to protein-induced satiety https://pubmed.ncbi.nlm.nih.gov/23466396/ The L-Cell in Nutritional Sensing and the Regulation of Appetite https://pubmed.ncbi.nlm.nih.gov/26258126/ Appetite hormones and energy intake in obese men after consumption of fructose, glucose and whey protein beverages https://pubmed.ncbi.nlm.nih.gov/17593904/ Hunger, ghrelin and the gut https://www.sciencedirect.com/science/article/abs/pii/S0006899318300386 Cholecystokinin https://pancreapedia.org/molecules/cholecystokinin Resistant Starch https://thehealthygrain.com/resistant-starch/ Dietary resistant starch upregulates total GLP-1 and PYY in a sustained day-long manner through fermentation in rodents https://pubmed.ncbi.nlm.nih.gov/18796545/ Acute Effect of Resistant Starch on Food Intake, Appetite and Satiety in Overweight/Obese Males https://pubmed.ncbi.nlm.nih.gov/30558330/ Metabolic phenotypes and the gut microbiota in response to dietary resistant starch type 2 in normal-weight subjects: a randomized crossover trial https://pubmed.ncbi.nlm.nih.gov/30894560/ Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects https://pubmed.ncbi.nlm.nih.gov/10357731/ Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagon-like peptide 1 responses in patients with type 2 diabetes https://pubmed.ncbi.nlm.nih.gov/12600850/ A MUFA-rich diet improves postprandial glucose, lipid, and GLP-1 responses in insulin-resistant subjects https://pubmed.ncbi.nlm.nih.gov/17914131/My Ultimate Weight Loss Plan For 2024no More ExcusesThe 4th of July is one of my favorite #holidays. 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