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Learn more about becoming an Insider: https://www.benbikman.com Dr. Bikman’s Metabolic Classroom lecture this week explores the physiological role and implications of GLP-1 (glucagon-like peptide-1) and the GLP-1 receptor agonist drugs used for type 2 diabetes management and weight loss. Ben begins by explaining GLP-1 as a hormone produced in the intestines in response to food. It plays a vital role in slowing gastric emptying, suppressing glucagon, and regulating appetite by signaling fullness to the brain. These mechanisms contribute to its effects on stabilizing blood sugar and enhancing insulin sensitivity. He then delves into GLP-1 receptor agonists, drugs that mimic GLP-1’s actions, including semaglutide, liraglutide, and others marketed under brand names like Ozempic and Wegovy. These medications have gained fame for their weight loss efficacy, often leading to reductions in body weight by 15% or more. However, Ben emphasizes that weight loss involves not only fat but also lean mass, raising concerns about muscle loss and metabolic health. Additionally, he discusses the medications’ side effects, including depression, anhedonia, and potential long-term complications like fat cell development and gallstones. The lecture also addresses the diminishing returns of these drugs over time, noting that their efficacy in reducing cravings and improving eating control tends to wane after prolonged use. Dr. Bikman highlights that education on healthy eating and resistance training is crucial for maintaining health outcomes, as reliance solely on medication can lead to unintended consequences, such as increased fat regain after discontinuation. Ben concludes by stressing the importance of combining these drugs with a low-carb diet and resistance training to minimize muscle loss and optimize long-term outcomes. He encourages using the lowest effective dose and underscores the need for lifestyle changes to complement pharmacological interventions. Show Notes/References: For complete show notes and references referred to in this episode, we invite you to become a Ben Bikman Insider subscriber. As a subscriber, you’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben, ad-free Metabolic Classroom Podcast episodes, show notes and references, Ben’s Research Reviews Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more about becoming an Insider on our website: https://www.benbikman.com (Auto-Translate Note: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) #GLP1 #WeightLossDrugs #Ozempic #Wegovy #Semaglutide #Liraglutide #Type2Diabetes #DiabetesManagement #InsulinResistance #WeightLossTips #MetabolicHealth #DrBenBikman #MetabolicScience #MuscleHealth #MentalHealthMatters #LowCarbDiet #FatLoss #HealthRisks #DiabetesDrugs #ScienceExplained Timestamps: 00:01 - Introduction and Overview 02:16 - What is GLP-1? 03:15 - GLP-1's Role in Metabolism 05:08 - Appetite Regulation and Insulin Effects 07:05 - GLP-1 and Blood Sugar Management 08:10 - Introduction to GLP-1 Receptor Agonists 09:05 - Key GLP-1 Drugs and Brand Names 12:04 - Weight Loss Mechanisms of GLP-1 Drugs 14:06 - Mental Health Risks of GLP-1 Drugs 16:15 - Muscle Loss Concerns 18:24 - Fat Cell Differentiation and Regain Risk 20:07 - Long-Term Diminishing Effects 25:30 - Pancreatitis and Gallstones 29:11 - Closing Thoughts and Recommendations Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite electrolytes (and more): https://redmond.life (discount: BEN15) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Ben’s favorite exogenous ketone: https://www.americanketone.com (discount: Ben10) Other products Ben likes: https://www.amazon.com/shop/benbikmanphd Learn more about becoming an Insider on our website: https://www.benbikman.com

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James Brown presents a bold prediction for 2025, anticipating that a major media brand, comparable to CBS or NBC, may declare bankruptcy amidst shifting market dynamics. He highlights the increasing scrutiny on tech giants like Google and Facebook, suggesting they will navigate these challenges but will likely make high-profile concessions to maintain their standing. The future of public broadcasting appears precarious, with funding cuts expected and ongoing struggles for relevance. Additionally, Brown shares insights on weather patterns, forecasting a cool summer accompanied by an active hurricane season. He also points to a cultural shift where weight loss drugs like Ozempic could become the new trend in mental health solutions, raising important discussions around safety and lifestyle changes. James Brown delivers a thought-provoking commentary on potential developments in various sectors by 2025, beginning with a striking prediction regarding the media landscape. He anticipates that a well-established media brand, akin to CBS or NBC, may face bankruptcy—a notion that seems far-fetched today but is supported by underlying trends in the media industry. Brown elaborates on the precarious financial states of major media entities, suggesting that the shift in consumer preferences and the rise of digital platforms are exerting unsustainable pressure on traditional media outlets. As he explores this theme, he also touches upon the evolving landscape of antitrust scrutiny aimed at tech giants like Google and Facebook. While he believes these companies will endure the increased regulatory pressures, he foresees them making high-profile concessions to maintain their dominance and avoid disintegration. In addition to corporate predictions, Brown delves into public broadcasting's future, specifically highlighting NPR's challenges. As funding continues to dwindle, he predicts that NPR will face congressional hearings that could further jeopardize its financial stability. This discussion prompts a larger examination of public media's role in an increasingly fragmented media environment and its struggle to remain relevant amidst changing audience behaviors. Brown also addresses environmental factors, predicting a cooler summer juxtaposed with an active hurricane season, underscoring the unpredictable nature of climate impacts. He lightens the discourse with a quirky prediction about political trends in New York, where the revival of plastic bags might gain traction, reflecting a growing discontent with current environmental policies. Lastly, he examines a significant cultural shift, where weight-loss drugs like Ozempic could emerge as trendy solutions for mood enhancement, exemplifying a broader societal trend towards pharmaceutical interventions for lifestyle improvements. Engaging his audience, Brown invites listeners to share their thoughts on these bold predictions, encouraging a dialogue around the implications of these potential changes. Takeaways: • James Brown predicts that a major media brand, like CBS or NBC, may declare bankruptcy by 2025 due to current financial trends. • While antitrust efforts target tech giants like Google and Facebook, both companies are likely to survive despite scrutiny. • NPR faces ongoing funding challenges and will likely be called to congressional hearings regarding its financial future. • Expect a cool summer overall, but prepare for an active hurricane season in 2025. • A surprising political shift may occur in New York, with someone winning on a platform to bring back plastic bags. • Weight loss drugs will evolve to be viewed as new antidepressants, sparking debates around health and safety concerns. Links referenced in this episode: • jamesbrowntv.substack.com (https://jamesbrowntv.substack.com) Companies mentioned in this episode: • CBS • NBC • Google • Facebook • NPR • Ozempic

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A listener comment prompts a brief look at drugs and foods that focus on glucagon-like peptide-1. Why is there so much hype around this gut hormone and ways to affect it?