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Over a quarter of the Indian adult population is either obese, at risk of diabetes or are diabetic. This has become a marketing & business opportunity for a lot of fitness & healthtech companies with plain vanilla no science interventions focussed on either high protein, calorie counting, CGM driven or at worst GLP-1 drugs. But these companies fail to understand how human biochemistry works. These interventions, if they help in weight loss, is a stop gap arrangement. Weight gain is not the cause but the effect & symptom. Obesity is triggered by low grade chronic inflammation & our body tries its best to maintain a metabolic homeostasis. However, regular insults we do to our body by consuming toxins or ingesting those foods that are transformed by your microbiome into toxins or pro-inflammatory metabolites makes it hard for us to lose weight. Some of these metabolites include LPS, TMAO, P-cresol & more. While microbes living in our mouth & gut also produce certain beneficial metabolites & incretin hormones ( providing we are feeding them with the right food substrates) that maintain our metabolic health & make it hard for us to gain weight. One of the most important metabolites ( incretin hormone) is GLP-1. Yes, our body automatically produces GLP-1 by synthesising fibre & polyphenols in the food we eat. GLP-1 has multiple benefits via regulating various metabolic pathways-regulates blood sugar response, communicates with brain via gut-brain axis , telling that you are full & even tells stomach & intestine to slow the movement of digestive tract. However, these GLP-1 drugs which lot of companies claim mimics natural GLP-1 brings multiple side effects & just ingesting these drugs does not mean it will help you lose weight. -Effectiveness of GLP-1 drugs depends upon the functions of your microbiome. Certain microbes can synthesise these drugs into beneficial stuff that have positive correlation with glycemic reduction while some others if active & expressing virulence genes can interfere with synthesis of GLP-1 drugs . -Certain microbes if active & expressing virulence genes can degrade GLP-1, making you gain weight or develop type 2 diabetes. In such scenario, these drugs cannot help. -It has been found that obese have underexpressed NOS attributed to overexpression of tumour necrosis factor-α caused by microbial derived endotoxin LPS. Besides, there are multiple other factors that can suppress NOS/cause endothelial cell dysfunction such as overexpression of ADMA, oxidative stress( caused by P-cresol &/or Indoxyl Sulphate Production), TMAO & more. In order to understand the root cause of obesity, there is a need to understand multiple molecular pathways that trigger its onset/progression. We at Genefitletics measures these pathways to construct nutritional therapeutics interventions aligned with your biochemistry that reinstates yout metabolic homeostasis Citations https://pmc.ncbi.nlm.nih.gov/articles/PMC4112002/ https://pmc.ncbi.nlm.nih.gov/articles/PMC7021470/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 https://pmc.ncbi.nlm.nih.gov/articles/PMC10391832/ https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://pmc.ncbi.nlm.nih.gov/articles/PMC5082693/ #obesity #obesityfreeindia #obesityfreenation #obesityawareness #viralvideo #virlshort #viralreels #viral_video #viralshorts #viralnews #healthnews #healthtips #health #healthylifestyle #supplements #obesitymedicine #obesityprevention #obesityawareness #type2diabetes #diabetesawareness #diabetesmanagement #diabetescare #diabetescure

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Looking to shed some extra pounds? Include these foods in your diet for more effective fat loss: • Eggs 🥚 • Chicken Breast 🍗 • Cottage Cheese 🧀 • Greek Yogurt 🍦 • Rucola (Arugula) 🥬 • Berries 🍓 • 5% Ground Beef 🥩 Train hard, eat right, and watch your body transform! Disclaimer: The information shared is for general purposes only and shouldn’t replace professional or medical advice. Everyone’s body is different, so consult a healthcare professional for personalized guidance.

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It’s likely you already know that we’re big fans of the ketogenic diet. Just in case you’re unfamiliar with keto, at it’s very basic foundation it’s a low carb, moderate protein, high (healthy) fat diet. With carbs out of the picture, your body enters a state called “ketosis” where alternative energy sources called ketones are produced. It’s fantastic for fat/weight loss, to minimize inflammation, and to increase energy levels. People often have many of the same concerns regarding keto. The keto “flu” when you’re starting out. Digestion issues. Electrolyte imbalances. While these are all valid concerns, there are extremely simple steps to combat them. Trust us, the benefits are well worth it. MEET CARRIE: On this week’s episode we speak with Carrie Pattison, a national educator for Natural Factors (amongst other things). We wanted to Pick Carrie’s brain about some supplements that can help not only ease the pain of the keto journey, but make it even more rewarding with the addition of supplements. Whether you’re just starting your keto journey or if you’re a seasoned veteran, there’s plenty of things to take away from this episode. SOME TOPICS WE DISCUSS: What are some common problems and issues people have when on the keto diet? (8:31) What are some tips to keep the keto diet as more of a lifestyle vs a fad diet? (11:54) How does berberine impact the body when on a keto diet? (13:54) How do you combat lack of energy on the keto diet? (17:56) How do you address electrolyte imbalances when on the keto diet? (22:51) Why is taking greens so important? (26:59) How do we address constipation when on the keto diet? (32:49) SOME KEY TAKEAWAYS FROM THIS EPISODE: The keto diet is designed to help our bodies burn fat for fuel. (3:04) Berberine is one of the best herbs to help manage insulin levels. (13:23) Coffee all day long will not solve your energy issues. (18:17) A lot of the negative effects of keto are associated with an electrolyte imbalance but they are very easy to fix. (24:24) You can absorb up to 40% more protein when it’s fermented. (29:27)

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Chrissy Metz Is So Skinny Now — And Looks Absolutely Gorgeous! Actress Chrissy Metz, famous for her role in This Is Us, has undergone an amazing transformation that’s leaving fans speechless! Known for her openness about body positivity and personal struggles, Chrissy now looks healthier, happier, and stunningly gorgeous. In this video, we reveal her latest photos and the story behind her inspiring journey. 💫 Stay tuned till the end for before-and-after photos and how she achieved this incredible change! 💬 What do you think of Chrissy’s transformation? Share your thoughts in the comments! 👍 Like, share & subscribe for more celebrity transformations and inspiring stories! #chrissymetz #ChrissyMetzTransformation #ChrissyMetzWeightLoss #celebritynews #inspiringstories #thisisus

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Amy Burroughs, Terns Pharma CEO, joins  'Closing Bell Overtime' to talk progress in its GLP-1 drug development.

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