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00:00 - Intro 00:24 - Urgent Mounjaro Warning: Avoid Deadly Pancreatitis with Simple Blood Test 04:47 - Investigating Genetic Link Between Pancreatitis and GLP-1 Medicines 09:50 - Ozempic Danger Alert: 10 Deaths Linked to Serious Pancreas Problems 14:22 - Urgent Mounjaro Warning: Common Mistake Can Lead to Organ Failure 1. Urgent Mounjaro Warning: Avoid Deadly Pancreatitis with Simple Blood Test Discover the hidden risks of Mounjaro weight-loss injections and learn why a routine blood test could save your life. In this video, we cover: • Why GPs must screen for liver function, thyroid issues, pre-diabetes and high triglycerides before prescribing Mounjaro • How elevated triglyceride levels dramatically increase the risk of acute pancreatitis and organ failure • Real-world cases of severe dehydration, necrotic pancreatitis and fatal sepsis linked to GLP-1 jabs • The role of genetic testing in predicting adverse drug reactions and improving patient safety • Expert insights from nurse Rachael Joy and the MHRA’s latest guidance for UK jab users Whether you’re considering Mounjaro or already on the programme, understanding these vital precautions will help you stay safe and informed. Don’t start your next injection without watching this first! 2. Investigating Genetic Link Between Pancreatitis and GLP-1 Medicines Learn about the ongoing investigation by the MHRA and Genomics England into the genetic link between pancreatitis and GLP-1 receptor agonists like Ozempic and Wegovy. Discover how this research aims to reduce side effects through personalized treatment approaches and the role of genetic testing in minimizing adverse drug reactions. 3. Ozempic Danger Alert: 10 Deaths Linked to Serious Pancreas Problems In this urgent health update, we dive deep into the latest investigations surrounding GLP-1 weight loss drugs like Ozempic and Mounjaro. Key Insights: - UK regulators investigate nearly 400 reports of serious pancreas issues - At least 10 deaths potentially linked to weight loss medications - Acute pancreatitis risks explained by medical experts - What every Ozempic user needs to know about potential side effects Learn about the latest medical research, understand the risks, and make informed health decisions. If you're considering or currently using weight loss medications, this video is a must-watch for your safety. 4. Urgent Mounjaro Warning: Common Mistake Can Lead to Organ Failure A nurse has issued a stark warning about the dangers of using weight loss jabs like Mounjaro without proper blood tests. Learn how a common mistake could put you at risk of life-threatening organ failure, pancreatitis, and other serious side effects. In this video, we discuss the importance of mandatory blood screening before using weight loss injections, the hidden health risks that could make these jabs unsuitable for you, and the latest findings from the UK’s medicines regulator. Key topics covered: - The risks of high triglycerides and uncontrolled diabetes - How dehydration can lead to severe complications - The MHRA’s investigation into genetic traits and adverse reactions - Safety guidelines for prescribing weight loss jabs If you or someone you know is using Mounjaro, Ozempic, or Wegovy, this video is a must-watch to stay informed and safe.

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This is my Week 6 weigh-in on Mounjaro (also known as Zepbound / Tirzepatide / GLP-1). But this week, the jab didn't feel like it was working anymore... and the scale? Well, you'll have to see for yourself. I'm Del. I'm 48, bipolar, and trying to lose weight while fighting food noise, cravings, and low mood. Mounjaro helped me lose 10 lbs early on — but now it’s slowing down. Still, I’m working harder than ever. In this video, I take you through: 🧠 The reality of food noise + mental health 🐶 A day in my life (dogs, walks, He-Man battles & smoothies) ⚖️ My honest weigh-in results ❤️ Why community is one of the most important weight loss tools we have If you’re on Mounjaro or struggling with depression, weight, or motivation — you’re not alone. Let’s get through it together. 💬 Comment below if you're facing ups and downs — I always reply. 🔔 Subscribe to follow my journey: the wins, the setbacks, and everything in between. #Mounjaro #Zepbound #WeightLossJourney #MentalHealth #Tirzepatide #GLP1 #Bipolar #WeighIn #MounjaroUK #FoodNoise #weightlosssupport

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🎙️EP282｜善纖達，猛健樂，所有GLP-1受體促效劑：減重、控糖、護心腎？從藥物比較到臨床應用全解析 — 📌主題亮點： • ​ GLP-1受體促效劑的作用機轉是什麼？為何能兼顧控糖與體重管理？ • ​ Tirzepatide、Semaglutide、Liraglutide 怎麼選？療效與副作用比較一次看懂 • ​ 台灣健保給付限制、仿單外使用、心腎保護證據，全方位解析臨床現況 — 🔍內容解析： 本集重點： GLP-1受體促效劑（Glucagon-like peptide-1 receptor agonists, GLP-1 RAs）是目前糖尿病與肥胖症領域中最受矚目的藥物類別之一。這類藥物最初設計目的是控制第二型糖尿病血糖，但其延緩胃排空與降低食慾的機制，逐漸展現出優異的體重控制效果，成為減重治療的重要選項。 本集將全面比較目前臨床上常見的 GLP-1 RAs，包括 Semaglutide、Liraglutide、Dulaglutide、Exenatide、Tirzepatide 等，從作用機制、臨床療效、安全性，到心腎保護與健保給付現況，帶你掌握這波醫藥創新的核心。 — 🧩主題分段解析： — 🧬 GLP-1作用機轉：多重代謝效應的關鍵介質 GLP-1 是人體腸道於進食後釋放的一種腸泌素，具有多重生理功能： • ​ 刺激胰島素分泌（在高血糖狀態下） • ​ 抑制昇糖素分泌 • ​ 延緩胃排空，增加飽足感 • ​ 對中樞神經產生抑制食慾作用 GLP-1受體促效劑則是模擬這一生理訊號的藥物。由於天然 GLP-1 在體內迅速被 DPP-4 分解，因此這類藥物皆經修飾以延長半衰期，使其可每日或每週注射。 ⸻ 🩺 臨床療效比較：控糖與體重減輕雙重奏 根據大型隨機試驗與統合分析，GLP-1 RAs 在控制血糖（HbA1c）與體重管理上皆展現出顯著成效。 📌 各藥物臨床成效對比： 藥物名稱 HbA1c 降幅 體重減輕效果 使用頻率 核准適應症 Semaglutide -1.4 ~ -1.9% -6~15% 每週1次 第2型糖尿病、肥胖（國際核准） Tirzepatide -2.0 ~ -2.4% -10~20% 每週1次 第2型糖尿病（減重待核准） Liraglutide -1.0 ~ -1.5% -5~8% 每日1次 糖尿病、肥胖（Saxenda商品名） Dulaglutide -0.7 ~ -1.5% -2~5% 每週1次 糖尿病 Exenatide -0.8 ~ -1.0% -2~3% 每週或每日 糖尿病 其中 Tirzepatide 屬於 GIP/GLP-1 雙重受體促效劑，在 SURMOUNT 與 SURPASS 試驗中展現出前所未有的血糖控制與減重表現，有望改寫治療標準。 — 💖 心血管與腎臟保護：超越控糖的新方向 越來越多研究指出，GLP-1 RAs 除了降血糖與減重，也具有心腎保護效果，這點在糖尿病病人族群中特別重要。 📌 心血管研究亮點： • ​ LEADER試驗（Liraglutide）： 減少 MACE（重大心血管事件）13% • ​ SUSTAIN-6（Semaglutide）： 顯著降低心血管事件與腎功能惡化風險 • ​ REWIND（Dulaglutide）： 在高風險群中降低中風與心臟衰竭住院率 腎臟方面，GLP-1 RAs 可延緩 eGFR 下降速度、降低蛋白尿發生，與 SGLT2i 一同被納入 CKD 病患用藥建議中（KDIGO 2022）。 — ⚠️ 常見副作用與風險考量 GLP-1 類藥物最常見的不良反應是胃腸道不適： • ​ 噁心、嘔吐、腹瀉（劑量上升時尤明顯） • ​ 厭食、味覺改變 此外，也需注意以下安全議題： 1. ​ 胰臟炎風險： 少見但需警惕，特別是胰臟病史者 2. ​ 甲狀腺 C 細胞腫瘤： 動物實驗有顯示，故有甲狀腺腫瘤病史者應避免使用 3. ​ 低血糖風險： 單用風險低，但與 SU 類或胰島素併用時需留意 4. ​ 腎功能不全： 輕中度 CKD 可使用，但末期腎病需個別評估 目前各大指引皆建議以「緩慢劑量上升」的方式起始治療，以改善耐受性。 — 📋 台灣市場與健保現況：法規限制與臨床建議 雖然 GLP-1 RAs 在國際間已被廣泛應用於肥胖與代謝症候群治療，但在台灣市場仍受到幾項限制： 1. ​ 健保給付範圍有限： 僅核准用於第二型糖尿病患者，且常須 HbA1c ＞ 7.5% 且合併肥胖者 2. ​ 體重管理為仿單外使用： 減重用途目前無正式健保核准 3. ​ 高藥價問題： 自費族群常成經濟負擔障礙 4. ​ 專科醫師使用限制： 多數藥品須由內分泌科或新陳代謝科開立 根據 NHIA 公告，目前 Semaglutide（Ozempic）與 Liraglutide（Victoza）皆列為給付藥品，但需符合嚴格條件。 — 🚶‍♀️ 臨床應用建議：如何選擇最適合的 GLP-1 受體促效劑？ 臨床選擇應考慮以下因素： • ​ 目標： 控糖為主或減重為主？ • ​ 用藥頻率接受度： 每日注射 vs 每週注射 • ​ 腎功能狀況 • ​ 副作用耐受性 • ​ 病患偏好與經濟狀況 📌舉例： • ​ 對減重有高度期待者：Tirzepatide ＞ Semaglutide ＞ Liraglutide • ​ CKD早期患者：Semaglutide、Dulaglutide皆可考慮 • ​ 容易噁心者：可考慮低劑量起始且選擇耐受性較佳者如 Dulaglutide • ​ 自費負擔有限者：評估 Liraglutide 台灣仿單內使用是否適用 — 📣負責任的行動： GLP-1 受體促效劑不只是「減重神藥」，而是結合代謝改善、心腎保護與控糖成效的複合型療法。醫師在使用前應評估患者整體代謝風險、心血管病史與用藥習慣，避免將此藥物視為「萬靈丹」。 病患亦應接受完整衛教，了解可能副作用與正確使用方法，避免自行停藥或過度依賴。 — 📚熱門關鍵字： #GLP1受體促效劑 #Semaglutide #Ozempic #Tirzepatide #Mounjaro #Liraglutide #Saxenda #減重藥物 #糖尿病治療 #心血管保護 #腎臟保護 #胰島素促進劑 #胃排空延緩 #體重管理 #胃腸道副作用 #甲狀腺C細胞腫瘤 #台灣健保給付 #仿單外使用 #慢性腎病新療法 #糖尿病臨床指引 — 🎤主講人資訊： Dr.Happy Human Plumber｜心血管知識推廣者 擅長將複雜代謝藥物與心腎內科整合知識，轉化為清晰易懂的內容，關注台灣臨床處方趨勢與全球新藥發展，致力於提升醫病雙方的治療選擇品質。 Powered by Firstory Hosting (https://firstory.me/zh)

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Weight Loss Transformation Over 50. IS PART 1 of 2 - MAKE SURE YOU WATCH PART 2........... The Effects of Age on Weight Loss even while taking a GLP-1 medication such as Wegovy, Zepbound, or Saxanda is still being studied. My doctor and I have decided to switch me from Wegovy to Zepbound due to my very slow weight loss on Wegovy. In my research I have come across some information that indicates that weight loss on Zepbound may be greater than what I have seen on Wegovy., Wegovy vs. Zepbound Which Works Better for Older Adults? 1. Mechanism of Action Wegovy: Works as a GLP-1 receptor agonist, suppressing appetite and delaying gastric emptying. Zepbound Combines GLP-1 and GIP receptor agonism, enhancing appetite control and metabolic efficiency. 2. Effectiveness Wegovy: Studies show an average weight loss of 15-17% of body weight. Zepbound: Clinical trials report weight loss of up to 22.5%, making it potentially more effective. 3. Muscle Mass Preservation Wegovy: Effective for fat loss but may lead to some muscle loss. Zepbounf: May better preserve muscle mass during weight loss due to its dual action. 4. Metabolic Benefits Wegovy: Improves glucose control and insulin sensitivity. Zepbound: Offers additional benefits for metabolic flexibility and glucose regulation. Key Takeaway Choose Wegovy: If you prefer a medication with a proven track record for weight loss and are focused on reducing appetite. Consider Zepbound: If you're seeking enhanced weight loss, better metabolic flexibility, or additional benefits like muscle preservation. Always consult your healthcare provider to determine the best medication for your age, health conditions, and weight loss goals. As I continue my journey on switching from Wegovy 1.0 mg to Zepbound 5.0 I wanted to discuss different ways I am trying to stay motivated when the scale is not moving. I monitor my glucose with a continuous glucose monitor. My total weight loss to 13 lbs and while the weight loss might have been slow, my scale did project that I've lost fat and gained muscle. Continuous Glucose Monitor @signoshealth www.signoshealth.com @dexcomCGM FOR COLLABORATIONS: Contact me via email: [email protected] Levay Stevenson IG: @lifestyle_for_living DISCLAIMER: 1) This information in this video if for information and entertainment purposes only, so you should always speak to a health care provided about your unique health needs. 2) Please use this video as informational not as unique recommendations. 3) This advice is from Levay's own personal experience with Intermittent Fasting. Please be kind in the comments. 4) Don't forget to subscribe to this channel and ring the notification bell so that you never miss out. --------------------------------------------------------------------------------------------------------------------------- WEIGHT LOSS OVER 50 WOMEN OVER 50 WEIGHT LOSS TIRZEPATIDE WEIGHT LOSS GLP-1 MEDICATION JOURNEY ZEPBOUND WEIGHT LOSS WEIGHT LOSS MOTIVATION OVER 50 HEALTHY LIFESTYLE OVER 50 SELF-CARE DURING WEIGHT LOSS MATURE WOMEN WEIGHT LOSS WEIGHT LOSS TIPS FOR WOMEN GLP-1 WEIGHT LOSS JOURNEY TIRZEPATIDE FOR WOMEN MATURE WOMEN FITNESS OVER 50 HEALTH TIPS WOMEN'S HEALTH OVER 50 SUSTAINABLE WEIGHT LOSS HOLISTIC WEIGHT LOSS OVER 50 ANTI-AGING AND WEIGHT LOSS HEALTHY HABITS FOR MATURE WOMEN GLP-1 WEIGHT LOSS TIPS #wegovy #zepbound #mounjaro #weightlossjourney

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