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At the European Society for the Study of Diabetes (EASD) Annual Meeting in Barcelona, Steve Bain discusses the major challenges in developing an oral GLP-1 receptor agonist and how was this overcome with semaglutide. 1. What were the major challenges in developing an oral GLP-1 receptor agonist and how was this overcome with semaglutide? (0:05) 2. Is the oral formulation likely to replace other injectable GLP-1 receptor agonists? (2:12) 3. What have been the key take home messages from the PIONEER clinical trial programme? (3:02) 4. How does oral semaglutide compare with other oral agents such as empagliflozin and sitagliptin? (4:44) 5. Which patients are most likely to benefit from oral semaglutide? (5:37) Steve Bain has no conflicts of interest to declare in relation to this video. Filmed at the Annual Meeting of the European Association of the Study of Diabetes (EASD) Barcelona, Spain 2019.

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#WeightLossPills #ConsumerSafety #HealthRisks In this video, we delve into some of the most dangerous and ineffective weight loss pills that consumers should avoid. These products have been associated with serious health risks, hidden ingredients, and misleading claims. We explore the following issues: FDA warnings on tainted weight loss products containing undisclosed drug ingredients that pose significant health risks1. The video discusses specific cases like Body Shape Weight Loss System, which was found to contain sibutramine and phenolphthalein, both potentially harmful substances2. We examine the risks associated with sibutramine, including increased blood pressure and heart rate, and the potential cancer risk linked to phenolphthalein2. The video also covers the broader issue of unregulated dietary supplements marketed for weight loss, highlighting the FDA's inability to test all products on the market16. We discuss the importance of consulting healthcare professionals before taking any weight loss supplements and provide tips on recognizing signs of health fraud in weight loss product marketing6. Furthermore, we explore the recent concerns surrounding popular prescription weight loss drugs like Wegovy and Ozempic, including potential side effects such as stomach paralysis, pancreatitis, and bowel obstructions57. The video emphasizes the importance of proper medical supervision when using these medications and the potential long-term commitment required to maintain weight loss7. Lastly, we cover the risks associated with unapproved GLP-1 drugs used for weight loss, including illegally sold products containing semaglutide, tirzepatide, or retatrutide8. The video concludes by discussing the side effects of common weight loss medications like phentermine and tirzepatide, emphasizing the need for careful consideration and medical guidance when choosing weight loss interventions10. Sources: FDA - https://www.fda.gov/drugs/medication-health-fraud/tainted-weight-loss-products FDA - https://www.fda.gov/drugs/medication-health-fraud/public-notification-body-shape-weight-loss-system-contains-hidden-drug-ingredients National Institutes of Health - https://ods.od.nih.gov/factsheets/WeightLoss-HealthProfessional/ FDA - https://www.fda.gov/drugs/human-drug-compounding/fda-alerts-health-care-providers-compounders-and-patients-dosing-errors-associated-compounded CNN - https://www.cnn.com/2023/10/05/health/weight-loss-drugs-serious-digestive-problems-study/index.html FDA - https://www.fda.gov/drugs/frequently-asked-questions-popular-topics/questions-and-answers-about-fdas-initiative-against-contaminated-weight-loss-products UCHealth - https://www.uchealth.org/today/wegovy-vs-ozempic-the-truth-about-new-weight-loss-drugs/ FDA - https://www.fda.gov/drugs/postmarket-drug-safety-information-patients-and-providers/fdas-concerns-unapproved-glp-1-drugs-used-weight-loss UCSF Magazine - https://magazine.ucsf.edu/weight-loss-drugs-too-good-to-be-true Obesity Medicine Association - https://obesitymedicine.org/blog/5-common-weight-loss-medications-their-side-effects-obesity-medicine-association/ Video Tags: Weight Loss Pills, FDA Warnings, Hidden Ingredients, Health Risks, Dietary Supplements, Prescription Weight Loss Drugs, Side Effects, Consumer Safety, Medical Supervision, Weight Management #WeightLossPills #ConsumerSafety #HealthRisks

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In this video Doctor O'Donovan explains key facts you need to know about a medication called METFORMIN used to treat type 2 diabetes (also known as Glucophage, Fortamet, Axpinet, Diagemet, Glucient, Metabet). In the video we cover: What is metformin? (0.36) Who can and can't take it? (1.34) How to take it (2.36) Side effects (4.49) Use in pregnancy (7.40) Interactions (8.15) Key facts - Not everyone gets diabetes symptoms, so taking metformin may not make you feel any different. That does not mean it is not working, so keep on taking it. - It's best to take metformin with a meal to reduce the side effects. The most common side effects are feeling and being sick, diarrhoea, stomach ache and loss of appetite. Vitamin B12 deficiency is also a common side effect of taking metformin in higher doses or for long periods. - Metformin does not cause weight gain, unlike some other diabetes medicines. - If you have diabetes, you can get free prescriptions for all of your medicines, not just your diabetes ones. You'll need to have a medical exemption certificate. Further information via NHS website: https://www.nhs.uk/medicines/metformin/ Patient information leaflet: https://www.medicines.org.uk/emc/product/594/pil #doctor #diabetes #medication #pharmacy ************************************************************************ Connect through: YouTube: www.youtube.com/doctorodonovan​ TikTok: @doctorodonovan ************************************************************************** Disclaimer: The video is intended as an educational resource only. The information within this video or on this channel isn't designed to replace professional input, so if you have any medical issues please consult a medical provider. No professional relationship is being created by watching this video. Dr. O’Donovan cannot give any individual medical advice. All information should be verified for accuracy by the individual user. Dr O’Donovan accepts no responsibility for individual interpretation of data, although it is always accurate to the best of his knowledge at the time of the video being published. This is an EDUCATIONAL video. Images are used in accordance with fair use guidelines. Legal information: Content provided via YouTube is for general information purposes ONLY. Information videos are not produced to provide individualised medical advice. Medical education videos on Doctor O'Donovan are not a substitute for professional professional medical advice, diagnosis or treatment. NEVER ignore professional medical advice because of something you have heard here. ALWAYS consult your doctor regarding any concerns about your condition or treatment.

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Green tea has serious side effects that you must be aware of. These side effects can be life threatening. Why? Because these are green tea side effects significantly affect the liver and the kidneys. The main culprit is green tea extracts. The side effects are mainly from green tea extracts. The green tea extract side effects on liver can be devastating. Not only that green extract side effects on kidney can cause horrific life changing damage to your kidneys too. I talk about the green tea extract side effect liver damage reported on the BBC programme some months back. The main problem is the green tea extract egcg concentration. I talk about that in the video along with the green tea benefits that we are all aware of. So, regardless of the green tea benefits in particular weight loss, you need to be careful on how to use the green tea supplements. Because green tea supplements can cause liver failure. It is the green tea extracts in the supplements that cause the liver damage. If you are some one who is addicted to using weight loss supplements, you need to be careful about what supplements to buy. Green tea weight loss supplements can ruin your life because they can adversely affect your liver and your kidneys. So you need to be very careful with these green tea extract supplement, if you value your liver and your kidneys. https://link.springer.com/article/10.1007%2Fs00228-008-0610-7 https://www.bbc.co.uk/news/stories-45971416 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502701/ https://livertox.nih.gov/GreenTea.htm If you are someone who uses green tea extract for optimising your health, you should watch this video. Follow Dr Joe on Twitter https://twitter.com/thedrjoe Follow Dr Joe on facebook https://www.facebook.com/thedrjoe/

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Yes, it is actually possible even for more advanced people. This is a full guide explaining everything about a body recomposition. To calculate your maintenance calories: Link for a calorie calculator: https://www.calculator.net/calorie-calculator.html 00:00 Intro 0:16 People Who Can Do Body Recomp More Easy 1:06 Training 1:59 Diet 3:07 The Most Important Step About Fitness Made Easy: I make video's about health and fitness. I make it so it's easy to understand and learn from. I try to make my video's as factual and evidence based as possible, while also keeping it short. I do use AI for the voice over, but the rest is all made by me!