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Thanks for your support! 🙌 🔔 Subscribe for more health tips! 🚀 #HealthTips #WeightLoss #AppleCiderVinegar #mythsVito Keto Apple Gummies A Sweet Entry Into KetosisHomemade Apple Cider Vinegar 🍎 I use apple cider vinegar in so many ways, it has to be one of my favourite ingredients to use as a base for many of my home remedies, and it is actually really easy to make. 😊👍 As with other fermented foods, it’s loaded with probiotics, supporting digestion and helping to balance gut health too! 🌱 I often make mine using fallen and bruised apples from the orchard, or just any apple cores or scraps to prevent waste. ♻️🍏 If using whole apples I just roughly cut them into chunks, and then add unrefined cane sugar, the chopped apples, filtered water and a small amount of previously made apple cider vinegar to ensure proper fermentation (although not necessary, just recommended). 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Don’t miss out on these transformative techniques—watch now and take the first step towards a healthier, happier you! If you find this video helpful, please like and share it with friends! #BellyFat #WeightLoss #FitnessJourney #HealthyLiving #WomenHealth OUTLINE: 00:00:00 The Hidden Danger 00:01:13 Belly Fat Attacks! 00:01:43 Eat Your Way to a Flatter Stomach 00:02:15 Move That Body! 00:03:58 Winning Habits for a Smaller WaistlineResults Sharing Skin Care Weight Loss Result Medicine Free Life Ytshorts Shorts FitnessDrs Piña and Borlaug discuss the CMR substudy from the SUMMIT trial of tirzepatide in HFpEF/obesity. How does weight loss affect pericardial fat and skeletal muscle? https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_yt --TRANSCRIPT-- Ileana L. Piña, MD, MPH: Hello. I’m Ileana Piña, from Thomas Jefferson University in Philadelphia, Pennsylvania, and this is my blog. It’s a little bit different blog because I’m really interviewing a good friend about these glucagon-like peptide 1 (GLP-1) inhibitors. Some of our heart failure patients are getting their GLP-1 inhibitors from their primary care physicians, but many questions have arisen with the trial called SUMMIT. With us today is Barry Borlaug, who is in charge of the research section with the cardiovascular section of Mayo, and that is Mayo, Rochester, where it must be much colder even than here in Philadelphia. Barry, congratulations on that trial. Tell our audience a little bit about how the trial was structured because it’s important how we get into your information. SUMMIT Recap Barry A. Borlaug, MD: Thanks, Ileana. SUMMIT was a randomized, double-blind, placebo-controlled trial, testing the GLP-1/glucose-dependent insulinotropic polypeptide (GIP) agonist tirzepatide vs placebo in patients with heart failure with preserved ejection fraction (HFpEF). Unlike some other trials, this was real HFpEF with an ejection fraction of 50% or above. Patients were randomized 1:1 to tirzepatide, titrated up to 15 mg once weekly, or placebo and treated for a minimum of 52 weeks. The dual primary endpoints were worsening heart failure or cardiovascular death and quality of life by the Kansas City Cardiomyopathy Questionnaire (KCCQ) clinical summary score. The median duration of follow-up was 2 years. We continued follow-up until the last patient enrolled completed the full 52-week period of treatment. We found that, as compared to placebo, tirzepatide reduced the risk of worsening heart failure or cardiovascular death by 38%, which was statistically significant, and also improved the KCCQ clinical summary score. In addition to that, we also looked at other patient-centered outcomes like 6-minute walk distance and biochemical markers like C-reactive protein (CRP). We saw that there was also a significant improvement in exercise function measured by 6-minute walk distance and about a 40% decrease in CRP levels. Piña: How long did the total trial last, including the time that the drugs were being administered? Borlaug: The longest duration of follow-up was 3 years, and the median follow-up was 2 years. Piña: Were any of these patients also on sodium-glucose cotransporter 2 ( SGLT2) inhibitors ? Borlaug: Yeah, a minority of patients were also on SGLT2 inhibitors, about 17%. Piña: What was the baseline KCCQ score? Borlaug: Very poor. A s you know, physician-reported heart failure severity often doesn’t agree with patient reports. Overall, 72% of the patients were judged by their physicians to have class II heart failure, but the mean KCCQ score was just over 53, so pretty severe patient-reported limitations or severe HFpEF. Despite this — and this is often the case in HFpEF and obesity-related HFpEF — the median N-terminal pro-B-type natriuretic peptide ( NT-proBNP) was only 175. Piña: I was very surprised at that. Very surprised. That really is low. That was NT-proBNP. That wasn’t BNP. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/how-do-glp-1s-affect-cardiac-structure-and-skeletal-muscle-2025a10001qm?src=soc_ytParis Hilton Bold Christmas Look Elon Musk Zempic Santaweight Loss Reveal✅ Got 15-25 pounds to lose? ✅ Enjoy weight training, but you’re not sure if you’re getting the most out of your workouts? ✅ Struggle with fat loss because you’re not consistent with your nutrition strategy? Let's chat! Schedule a FREE 45 min Google Meet with me to talk about your needs. 💬 I'm doing research so I can learn more about how I can help YOU. 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With a wide selection of keto-friendly foods, supplements, and snacks, this store caters to those following a low-carb, high-fat diet and looking to achieve their health and wellness goals. Whether you are a seasoned keto enthusiast or just starting out on your journey, Chemist Warehouse on the Gold Coast has something for everyone. Availability of Keto Products One of the key reasons why the Gold Coast Keto Chemist Warehouse is a go-to destination for many individuals is the availability of a wide range of keto products. From keto-friendly snacks like nuts and seeds to specialty items like MCT oil and collagen supplements, this store has everything you need to support your ketogenic lifestyle. With a dedicated section for keto products, it is easy to navigate and find exactly what you are looking for. In addition to individual products, the Gold Coast Keto Chemist Warehouse also offers pre-packaged keto meals and snacks for those looking for convenient options. 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A: Some popular keto products available at the Gold Coast Keto Chemist Warehouse include MCT oil, keto protein bars, sugar-free chocolate, and keto-friendly baking mixes. Q: Can I find pre-packaged keto meals at the Gold Coast Keto Chemist Warehouse? A: Yes, the Gold Coast Keto Chemist Warehouse offers a selection of pre-packaged keto meals and snacks for convenient on-the-go options. Q: Do I need a prescription to purchase keto products at Chemist Warehouse on the Gold Coast? A: No, you do not need a prescription to purchase keto products at the Gold Coast Keto Chemist Warehouse. These products are available over the counter for anyone looking to support their ketogenic lifestyle. Q: Are there any gluten-free or dairy-free options available at the Gold Coast Keto Chemist Warehouse? A: Yes, the Gold Coast Keto Chemist Warehouse carries a variety of gluten-free and dairy-free keto products to accommodate different dietary preferences and restrictions. Keto Supplements Video What Supplements I Use And Why Keto Supplement Recommendations Obesity is a major health concern worldwide, with millions of individuals struggling to lose weight and improve their overall well-being. While diet and exercise are recommended as the first line of defense against obesity, some individuals may require additional help in their weight loss journey. This is where medications such as semaglutide come into play. Semaglutide is a medication typically used to treat type 2 diabetes but has also shown promising results in helping non-diabetic individuals lose weight. The Science Behind Semaglutide Semaglutide belongs to a class of medications known as glucagon-like peptide-1 receptor agonists (GLP-1 RAs). These medications work by mimicking the effects of the hormone GLP-1, which helps regulate blood sugar levels and promotes feelings of fullness. By activating the GLP-1 receptor, semaglutide can help slow digestion, reduce appetite, and increase insulin production. In addition to its effects on weight loss, semaglutide has also been shown to improve cardiovascular health in individuals with obesity. Studies have demonstrated that semaglutide can reduce the risk of heart attacks, strokes, and other cardiovascular events in individuals with pre-existing cardiovascular disease. Overall, semaglutide offers a comprehensive approach to weight loss by targeting multiple physiological pathways involved in obesity. By addressing both appetite control and insulin regulation, semaglutide can help individuals achieve sustainable weight loss and improve their overall health. Potential Side Effects of Semaglutide As with any medication, semaglutide can cause side effects in some individuals. The most common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects typically improve over time as the body adjusts to the medication. In rare cases, semaglutide can also cause more serious side effects such as pancreatitis or thyroid tumors. It is important to discuss the risks and benefits of semaglutide with your healthcare provider before starting treatment, especially if you have a history of pancreatitis, thyroid cancer, or other medical conditions. If you experience any concerning side effects while taking semaglutide, it is important to contact your healthcare provider immediately. They can help determine the best course of action and make any necessary adjustments to your treatment plan. Who Can Benefit from Semaglutide for Weight Loss? Semaglutide is typically prescribed for individuals with a body mass index (BMI) of 30 or higher, or a BMI of 27 or higher with obesity-related comorbidities such as high blood pressure or type 2 diabetes. If you have been struggling to lose weight through diet and exercise alone, semaglutide may be a viable option to consider. It is important to note that semaglutide is not a magic bullet for weight loss and should be used in conjunction with lifestyle modifications such as a healthy diet and regular physical activity. Your healthcare provider can help create a comprehensive weight loss plan that incorporates semaglutide and other strategies to help you achieve your weight loss goals. Overall, semaglutide can be a valuable tool in the fight against obesity for non-diabetic individuals who have not seen success with traditional weight loss methods. With proper medical supervision and lifestyle changes, semaglutide can help individuals achieve long-term weight loss and improve their overall health. Conclusion Semaglutide is a promising medication for weight loss in non-diabetic individuals, offering a comprehensive approach to obesity treatment by targeting appetite control and insulin regulation. While semaglutide can help individuals achieve sustainable weight loss, it is important to be aware of potential side effects and discuss the risks and benefits with your healthcare provider. By incorporating semaglutide into a comprehensive weight loss plan that includes lifestyle modifications, individuals can successfully combat obesity and improve their overall well-being.