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THANKS FOR WATCHING.... 😃😃😃 Please don't forget to subscribe Music: www.bensound.com No Audiobook No music remix No Audio podcast No song makingBlue Vibe CBD Gummies Cost: Price Breakdown and Value AnalysisOncotarget published this trending research paper on February 2, 2021, entitled, "Testosterone deficiency in men receiving immunotherapy for malignant melanoma" by researchers from the University of Iowa. Abstract: Immunotherapy has been established as a standard of care for patients with malignant melanoma, however, the long-term side-effects of immunotherapy are still emerging. Studies over the last decade have documented increasing reports of endocrine dysfunction following the initiation of immunotherapy. Our study aimed to detect the proportion of men who have low testosterone before, during, and or/after receiving immunotherapy for malignant melanoma, and to determine the proportion of men who receive testosterone replacement therapy after detection of low testosterone. We performed retrospective chart review of patients with malignant melanoma treated with immunotherapy. Low testosterone was identified in 34 out of 49 patients at some point during their treatment with immunotherapy. Despite low testosterone levels in two-thirds of patients, only three patients were treated with testosterone replacement therapy. In addition to laboratory evidence of low testosterone, patients were also symptomatic as 43 out of 49 patients reported fatigue to their providers. Four patients developed hypophysitis and subsequent hypopituitarism, all of whom were receiving Ipilimumab. We conclude that patients with stage 3 or 4 melanoma treated with immunotherapy appear to be at an increased risk of developing testosterone deficiency during their treatment. Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.27876 DOI - https://doi.org/10.18632/oncotarget.27876 Full text - https://www.oncotarget.com/article/27876/text/ Correspondence to - Madeline Peters - [email protected] Keywords - cancer, melanoma, immunotherapy, testosterone deficiency, androgens, skin cancer About Oncotarget Oncotarget is a bi-weekly, peer-reviewed, open access biomedical journal covering research on all aspects of oncology. To learn more about Oncotarget, please visit https://www.oncotarget.com or connect with: SoundCloud - https://soundcloud.com/oncotarget Facebook - https://www.facebook.com/Oncotarget/ Twitter - https://twitter.com/oncotarget YouTube - https://www.youtube.com/c/OncotargetYouTube/ LinkedIn - https://www.linkedin.com/company/oncotarget Pinterest - https://www.pinterest.com/oncotarget/ Reddit - https://www.reddit.com/user/Oncotarget/ Oncotarget is published by Impact Journals, LLC please visit https://www.ImpactJournals.com or connect with @ImpactJrnls Media Contact [email protected] 18009220957Penis Enlargement Techniques A Comprehensive Guide 2025Join me today as I show you how to increase nitric oxide levels naturally! #nitricoxide #menshealth #DrRachaelRoss #DrRachael #edprevention #erectiledysfunctionTop Strategies To Improve Penile Blood Flow And Overcome Erectile Dysfunction Boost Male Performance✨Erection cock rings at 50% off almost any single item + free discreet shipping + free 3 hot DVDs & a mystery gift when you enter promo code MYFIRST at checkout at adamandeve.com ✨ Are you ready to learn all about penis rings? 👌👌 Now, I’ve got a sex toy that all guys don’t think they need, but then they realize it’s the best thing ever! 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And please share this video . #healthcare এই ডাক্তার বাবুর সাথে যোগাযোগ করতে : PEERLESS HOSPITAL 360, Pancha Sayar Rd, Sahid Smirity Colony, Pancha Sayar, Kolkata, West Bengal 700094Vigora 100 Sildenafil Erectile Dysfunction Medviews Over the past decade, CBD products have seen a clear rise in terms of sales and popularity. People have associated CBD with plenty of health benefits, from treating insomnia to alleviating pain and anxiety to even helping with erectile dysfunction (ED). CBD gummies for ED have in particular seen a huge increase in sales as they offer a supposedly natural and organic solution to many men suffering from ED. They claim to help treat ED symptoms and improve their sex lives as well. But can CBD gummies for ED actually provide these benefits? Do they really work and, most importantly, are they safe? In this article, we are going to put the claims of CBD gummies for ED under a scientific microscope. The Science Behind CBD Gummies for ED The promised effect of CBD gummies used for ED rests upon the potential of CBD to improve blood flow and circulation which are two major determinants of an erection. CBD is known to have a vasodilatory effect that could relax and widen blood vessels thereby improving circulation to the penis which could help erectile function. More so, CBD holds anti-inflammatory properties. Theoretically, this could help lower inflammation in blood vessels which is one of the potential causes of ED. With these proven effects of CBD, it does not seem too far-fetched to have CBD incorporated into sexual function. Another potential mechanism of action by which CBD gummies for ED could work is via its ability to directly or indirectly exert anxiolytic (ie, anxiety-reducing) effects in men with ED. As alluded to earlier, anxiety and stress can worsen ED by creating a mental block in the brain that blunts messages being sent to the penis which are necessary to begin and maintain an erection. CBD has reportedly been explored for its pharmacodynamic effects with regard to anxiety, as well as its metabolic effects to reduce stress. Therefore, a reasonable mechanism by which ED could potentially be improved in men is to alleviate anxiety and stress in their lives via the use of CBD. Plus, CBD gummies for ED are said to have antioxidant properties, a benefit that could also help some aspects of sexual health. Oxidative stress and damage caused by free radicals can contribute to poor sexual function and a person’s fertility, research suggests. By fighting against free radicals and lowering overall oxidative stress, CBD could help to decrease damage to the reproductive system and support healthy sexual function. This, in principle, could be beneficial for men with ED and other sexual health issues. Evidence for the Effectiveness of CBD Gummies for ED The possible mechanisms of action for CBD gummies to treat ED are exciting, however there is still a scarcity of evidence investigating the effects of CBD for sexual health and function. Although a few studies have looked into the effects of CBD on these issues in humans, the majority have been animal modelling studies and small peer-reviewed clinical trials. There remains a need for further, high-quality research to more definitively establish the efficacy of CBD gummies for ED in humans. Another issue stemming from research on CBD and ED is lack of standardised dosage and formulations of CBD products. CBD products often differ in consistency, purity, and quality, and these variables make discerning the effectiveness of CBD products for ED in current research difficult. Individual responses to CBD supplements also vary depending on a number of factors including metabolism, genetics and underlying medical conditions, all adding to the difficulty in assessing its effectiveness. Also, in contrast to ED medications that are regulated by the Food and Drug Administration (FDA), CBD gummies for ED would likely not face the same regulations, which means their safety and quality cannot be guaranteed. ED sufferers should be cautious about purchasing and using CBD gummies for ED, and should see a healthcare provider before using any new ED treatment to ensure the effectiveness, safety, and appropriateness of the treatment. Are CBD Gummies a Legitimate Treatment for ED? In conclusion, though CBD gummies can be a natural and viable ED-treatment option for men, there are very few studies that support its use for treating erectile dysfunction. The strains and mechanisms of action involved in ED also help to understand how CBD may work to improve erectile function. It’s important to note that there is very little evidence currently available to support the effectiveness of CBD gummies as ED-treatments. However, it is still too early to dismiss their potential. Importantly, if you are thinking of using CBD gummies for ED, you should follow a health care provider for follow-up visits to determine treatment efficacy and to ensure it is safe to use for you. CBD is safe and well-tolerated for most people, but it can interact with some medications. Additionally, it can cause side-effects in some people, so it is important that you talk to your health care provider. What It Means When You Ejaculate But No Sperm Comes Out Insights From A Female DoctorOfficial Website With 50% Discount : ✅ https://bit.ly/thunderblack_official ✅ https://bit.ly/thunderblack_official ✅ https://bit.ly/thunderblack_official Thunder Black Male Enhancement Pills Reviews - Thunder Black Review Is it possible to enlarge the penis safely and effectively at home? 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