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Usually because these medications affect a man's hormones, nerves or blood circulation, resulting in ED, or an increased risk for Erectile Dysfunction. 0:25 Dan Hammer Health Facebook: https://www.facebook.com/DanHammerHealth Website: https://www.danhammerhealth.com/ 0:34 WebMD Link https://www.webmd.com/erectile-dysfunction/guide/ed-psychological-causes 0:47 Antidepressants. Many antidepressants cause sexual side effects because they increase serotonin levels. This can then affect other hormones and neurotransmitters, such as testosterone and dopamine. One study found that men taking SSRIs (selective serotonin reuptake inhibitors), such as fluoxetine (Prozac) and sertraline (Zoloft), were more likely to experience erectile dysfunction than men who were not taking antidepressants. Tricyclic antidepressants, such as amitriptyline, imipramine and nortriptyline, have also been associated with sexual side effects, including erectile dysfunction. 1:24 Anti-anxiety medications Medications used to treat anxiety and panic disorders may also affect other hormones and neurotransmitters, such as testosterone and dopamine. One study found that men taking benzodiazepines, such as alprazolam (Xanax) and diazepam (Valium), were more likely to experience erectile dysfunction than men who were not taking these drugs. Another study found that men taking buspirone (Buspar), a medication used to treat anxiety, were also more likely to experience erectile dysfunction. 1:58 Antihistamine medicines Antihistamines block the action of histamine, a chemical in the body that is involved in allergic reactions but also healthy erections. 2:08 Blood pressure medications This is the one class of medications that can have the greatest negative effect on men's sexual health. All blood pressure medications can cause erectile dysfunction. But medications like diuretics (or “water pills”) have the greatest probability to cause ED. 2:26 Cancer treatments Cancer treatments, such as radiation therapy and chemotherapy, can also cause sexual side effects. 2:34 Tranquilizers These drugs most likely cause ED by directly suppressing nerve signals or possibly by changes in hormonal signaling. 2:43 Diabetes medications Many men with diabetes take multiple medications. The interaction between medications is hard to define, and can have unwanted side effects like ED. 2:56 Prostate cancer treatments Prostate cancer treatments, such as surgery and radiation therapy, can cause nerve damage that effects the ability to get an erection. If you're taking any of these medications, and find that you are experiencing erectile dysfunction, then talk to your doctor about other treatment options. 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