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GLP-1 (Glucagon-Like Peptide-1) inhibitors, more accurately known as GLP-1 receptor agonists, are a class of medications primarily used to treat type 2 diabetes and obesity. Here's a comprehensive look at what they are, how they work, their benefits, and considerations: How They Work: Mimicking GLP-1: GLP-1 receptor agonists mimic the function of the GLP-1 hormone, which is naturally released in the gut in response to food intake. They stimulate insulin secretion from the pancreas when blood glucose levels are high, suppress glucagon release (which would normally increase blood glucose), slow gastric emptying, and increase satiety signals to the brain. Mechanisms: Insulin Release: They help the body release insulin more effectively in response to meals. Glucagon Inhibition: They reduce the amount of glucagon, which helps lower blood sugar. Gastric Emptying: By slowing how quickly food leaves the stomach, they control post-meal blood sugar spikes. Appetite Suppression: They signal to the brain to reduce food intake, aiding in weight management. Benefits: Blood Sugar Control: Effective in lowering HbA1c levels, managing blood sugar in type 2 diabetes. Weight Loss: They have been shown to reduce appetite and body weight, making them useful for obesity management. Cardiovascular and Renal Benefits: Some GLP-1 receptor agonists have demonstrated benefits in reducing cardiovascular risks and improving renal outcomes in diabetic patients. Common Medications: Semaglutide (Ozempic for diabetes, Wegovy for weight loss) Liraglutide (Victoza for diabetes, Saxenda for weight loss) Dulaglutide (Trulicity) Exenatide (Byetta, Bydureon) Tirzepatide (Mounjaro, Zepbound) - a dual agonist that also targets GIP receptor. Side Effects: Gastrointestinal Issues: Nausea, vomiting, diarrhea, and constipation are common, especially when starting treatment. Ozempic Face: Rapid weight loss can lead to sagging skin on the face. Other Side Effects: Less common but more serious side effects include pancreatitis or potential thyroid tumors. Considerations: Administration: Most are injectable, though there's an oral semaglutide option. Cost: These medications can be expensive, potentially limiting access. Off-label Use: There's growing off-label use for weight loss, which brings up debates on ethics, safety, and long-term effects. Insurance and Coverage: Coverage can be variable, with some insurance plans not covering these drugs for weight loss unless certain criteria are met. Long-term Effects: While effective, the long-term effects are still under study, especially with the newer drugs and higher doses used for weight loss. Current Developments: Research: There's ongoing research into their use for other conditions like non-alcoholic fatty liver disease and polycystic ovary syndrome. Market Impact: The popularity of these drugs has significantly influenced the pharmaceutical market, with companies like Novo Nordisk and Eli Lilly seeing substantial growth due to these medications. In summary, GLP-1 receptor agonists represent a significant advancement in managing type 2 diabetes and obesity, offering multiple health benefits alongside some considerations regarding side effects, costs, and ethical use.

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Gastrointestinal hormones called incretins such as Glucagon-like peptide-1 also known as GLP-1, lowers the blood sugar levels by stimulating the production of insulin when it is needed (for example after eating) and reducing the production of glucagon by the liver when it is not needed (for example during digestion). They also slow down digestion, decrease appetite and reduces weight. Based on these beneficial effects of Glucagon-like peptide-1, certain Glucagon-like peptide-1 receptor agonists, also known as GLP-1 receptor agonists or incretin mimetics, were developed for treatment of hyperglycemia in diabetic patients. Medications in these class includes, exenatide (trade names Byetta and Bydureon), liraglutide (trade names Victoza and Saxenda), lixisenatide (trade name Lyxumia), albiglutide (trade name Tanzeum), dulaglutide (trade name Trulicity) and Semaglutide. Semaglutide (trade name, Ozempic) is a medication developed by Danish company Novo Nordisk. Originally developed for the treatment of type 2 diabetes in 2012. Injection version of the drug has been approved by the US Food and Drug Administration (FDA) in 2017, and by the European Commission, Health Canada and the Japanese Ministry of Health, Labour and Welfare in 2018. On 20 Sep 2019, The U.S. Food and Drug Administration, approved Novo Nordisk's Rybelsus (containing semaglutide) oral tablets, to improve control of blood sugar in adult patients with type 2 diabetes, along with diet and exercise. The efficacy and safety of Rybelsus in reducing blood sugar in patients with type 2 diabetes were studied in several clinical trials, two of which were placebo-controlled and several of which were compared to other GLP-1 injection treatments. Rybelsus was studied as a stand-alone therapy and in combination with other diabetes treatments, including metformin, sulfonylureas (insulin secretagogues), sodium-glucose co-transporter-2 (SGLT-2) inhibitors, insulins and thiazolidinediones, all in patients with type 2 diabetes. In the placebo-controlled studies, Rybelsus as a stand-alone therapy resulted in a significant reduction in blood sugar (hemoglobin A1c) compared with placebo, as determined through HbA1c tests, which measure average levels of blood sugar over time. Recommended dose of Rybelsus: Rybelsus can be started with 3 mg once daily for 30 days. After 30 days on the 3 mg dose, it can be increased to 7 mg once daily. Dose may be increased to 14 mg once daily if additional glycemic control is needed after at least 30 days on the 7 mg dose. It is not recommended as first-line therapy for patients inadequately controlled on diet and exercise and Not indicated for use in patients with type 1 diabetes mellitus or treatment of diabetic ketoacidosis. Adverse reactions and Contraindications: The most common adverse reactions, reported in patients treated with Semaglutide are gastrointestinal side effects including nausea, abdominal pain, diarrhea, decreased appetite, vomiting and constipation. Thyroid c-cell tumors. Pancreatitis. Diabetic Retinopathy Complications. Hypoglycemia. Acute Kidney Injury. Hypersensitivity Reactions. Thank You for watching this video. Please like, subscribe, share and hit the bell icon for more such videos. Please visit my blog at: http://www.medicalinfo4u.com/ Please check out my other videos below: FDA new drug approvals for treatment of hypotension (Biorphen), AHUS (Ravulizumab), cystic fibrosis: https://youtu.be/gS-fY71ddgU FDA approves Xeris’s Gvoke (glucagon pen) to treat severe hypoglycemia in diabetes patients: https://youtu.be/zy2LK91vq90 FDA approves nasal glucagon for treatment of severe hypoglycemia: https://youtu.be/kLfIKCcHtpU SGLT2 inhibitors: Do you know about this new diabetes medications? https://youtu.be/EtNM0dX36c8 6 MAJOR LONG TERM COMPLICATIONS OF DIABETES: https://youtu.be/6Yfrr9L6tCk Side effects of steroids: https://youtu.be/iEagfQUQs8E #MedicalInfo4U #FDAapprovedmedicine #newmedicine #Rybelsus #Gvoke #NovoNordisk #GLP1agonists

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While Fat Burning Keto Gummies are specifically designed to support a ketogenic diet, you can still benefit from their fat-burning properties even if you’re not following a strict keto plan. However, for optimal results, it’s recommended to pair Fat Burning Keto Gummies with a low-carb, high-fat diet and regular exercise.

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Fat Burning Keto Gummies are available for purchase online through various retailers and health supplement stores. Be sure to buy from a reputable source to ensure that you’re getting a high-quality product that meets safety standards. Check the ingredients list and reviews before making a purchase to ensure that Fat Burning Keto Gummies are the right choice for you.

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Are you seeking effective dietary options to aid in weight management? In this informative video, we explore five foods renowned for their fat-burning properties, akin to the effects of Ozempic. Delve into the nutritional benefits and mechanisms behind these foods that can enhance your metabolism and promote weight loss. By incorporating these items into your meals, you can take proactive steps toward achieving your health goals. Join us as we provide detailed insights and practical tips for integrating these fat-burning foods into your daily diet. Make informed choices and embark on a journey toward a healthier lifestyle today!