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Can you decrease or even stop taking some or all of your medications? There is no universal answer to this question; it depends on the individual. Psychotropic medications are typically first-line therapy for treating serious mental illness and can be life-saving. But over time, medications alone may not be completely effective in treating symptoms. And especially at high doses, they can come with problematic side effects. Metabolic nutritional therapy, specifically with nutritional ketosis, can add another treatment layer and may help promote cognitive function, mood stability and energy and overall functioning. Anecdotal evidence and growing numbers of case reports show that nutritional ketosis can help people be well enough to consider lowering the doses and number of their medications. That said, we cannot stress enough that it is essential that anyone considering reducing their medications work with their prescribing clinician, whether or not they are using nutritional ketosis as a treatment strategy. Table of Contents: 0:00 - Introduction 3:45 - Interview with Dr. Georgia Ede 32:16 - Interview with Matt Baszucki 53:59 - Conclusion Experts featured in this video: Georgia Ede, MD - www.diagnosisdiet.com Twitter @GeorgiaEdeMD Ketogenic Diets and Psychiatric Medications https://www.psychologytoday.com/us/blog/diagnosis-diet/201803/ketogenic-diets-and-psychiatric-medications Matt Baszucki, co-host of Bipolarcast on YouTube Bipolarcast Episode 1: Interview with Matt Baszucki on Ketogenic Diet and Bipolar Disorder https://www.youtube.com/watch?v=zNI8asTF5w8&t=2s Study Referenced: The Ketogenic Diet for Refractory Mental Illness: A Retrospective Analysis of 31 Inpatients https://pubmed.ncbi.nlm.nih.gov/35873236/ Follow our channel for more information and education from Bret Scher, MD, FACC, including interviews with leading experts in Metabolic Psychiatry. Learn more about metabolic psychiatry and find helpful resources at https://metabolicmind.org/ About us: Metabolic Mind™ is a nonprofit initiative incubated by Baszucki Group. Our mission is to provide education and resources in the emerging field of metabolic psychiatry, including ketogenic interventions for mental disorders. Our channel is for informational purposes only. We are not providing individual or group medical or healthcare advice nor establishing a provider-patient relationship. Many of the interventions we discuss can have dramatic or potentially dangerous effects if done without proper supervision. 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In a clinical trial involving over 1,800 participants, those who received tirzepatide experienced an average weight loss of 12-15% of their body weight over the course of 40 weeks. This weight loss was sustained over a 78-week period, with participants continuing to see improvements in their overall health and well-being. Overall, tirzepatide has shown promising results in promoting weight loss and improving metabolic health in individuals with obesity and type 2 diabetes. Its dual mechanism of action, targeting both GIP and GLP-1 receptors, makes it a unique and potentially effective treatment option for these conditions. Semaglutide Semaglutide is another injectable medication that belongs to the GLP-1 receptor agonist class. It works by stimulating insulin secretion and reducing glucagon production, leading to improved blood sugar control. Like tirzepatide, semaglutide has also been shown to promote weight loss in individuals with obesity and type 2 diabetes through its effects on appetite regulation and energy balance. In clinical trials, semaglutide has demonstrated significant weight loss effects, with participants experiencing an average weight loss of 10-14% of their body weight over the course of 52 weeks. This weight loss was sustained over a 104-week period, with participants also seeing improvements in their cardiovascular risk factors and overall quality of life. Overall, semaglutide has proven to be an effective treatment option for individuals with obesity and type 2 diabetes who are looking to lose weight and improve their metabolic health. Its once-weekly dosing schedule and favorable side effect profile make it a convenient and well-tolerated option for many patients. Comparing Effectiveness in Weight Loss When comparing tirzepatide and semaglutide in terms of their effectiveness in promoting weight loss, several factors must be taken into consideration. Both medications have been shown to lead to significant weight loss in individuals with obesity and type 2 diabetes, but there are some differences in their mechanisms of action and side effect profiles that may influence treatment decisions. One key difference between tirzepatide and semaglutide is their dual versus single receptor agonist activity. Tirzepatide targets both GIP and GLP-1 receptors, while semaglutide specifically targets GLP-1 receptors. This dual mechanism of action may provide additional benefits in terms of weight loss and metabolic control, but it may also increase the risk of certain side effects. In terms of weight loss outcomes, both tirzepatide and semaglutide have been shown to lead to similar amounts of weight loss in clinical trials. 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