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Inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2. The first agent of the class – sitagliptin – was approved by the FDA in 2006.[1] Glucagon increases blood glucose levels, and DPP-4 inhibitors reduce glucagon and blood glucose levels. The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP),[2][3][4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels. A 2018 meta-analysis found no favorable effect of DPP-4 inhibitors on all-cause mortality, cardiovascular mortality, myocardial infarction or stroke in patients with type 2 diabetes.[5] ExamplesEdit Drugs belonging to this class are: Sitagliptin[6] (FDA approved 2006, marketed by Merck & Co. as Januvia) Vildagliptin[7] (EU approved 2007, marketed in the EU by Novartis as Galvus) Saxagliptin (FDA approved in 2009, marketed as Onglyza) Linagliptin (FDA approved in 2011, marketed as Tradjenta by Eli Lilly and Company and Boehringer Ingelheim)[8] Gemigliptin (approved in Korea in 2012, marketed by LG Life Sciences)[9] Marketed as Zemiglo Anagliptin (approved in Japan in 2012, marketed by Sanwa Kagaku Kenkyusho Co., Ltd. and Kowa Company, Ltd.)[10] Teneligliptin (approved in Japan in 2012[11]) Alogliptin (FDA approved 2013, marketed by Takeda Pharmaceutical Company) Trelagliptin (approved for use in Japan in 2015) Omarigliptin (MK-3102) (approved in Japan in 2015,[12] developed by Merck & Co.; research showed that omarigliptin can be used as once-weekly treatment and generally well-tolerated throughout the base and extension studies[13]) Evogliptin (approved for use in South Korea[14]) Gosogliptin (approved for use in Russia[15]) Dutogliptin (being developed by Phenomix Corporation), Phase III[16] Other chemicals which may inhibit DPP-4 include: Berberine, an alkaloid found in plants of the genus Berberis, inhibits dipeptidyl peptidase-4 which may at least partly explains its antihyperglycemic activity.[17] Adverse effectsEdit In those taking sulphonylureas, there is an increased risk of low blood sugar.[18] Adverse effects, including nasopharyngitis, headache, nausea, heart failure, hypersensitivity and skin reactions. The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines like sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. FDA has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors.[19] However, studies assessing risk of rheumatoid arthritis among DPP-4 inhibitor users have been inconclusive.[20] A 2014 review found increased risk of heart failure with saxagliptin and alogliptin, prompting the FDA in 2016 to add warnings to the relevant drug labels.[21] A 2018 meta analysis showed that use of DPP-4 inhibitors was associated with a 58% increased risk of developing acute pancreatitis compared with placebo or no treatment.[22] A 2018 observational study suggested an elevated risk of developing inflammatory bowel disease (specifically, ulcerative colitis), reaching a peak after three to four years of use and decreasing after more than four years of use.[23] CancerEdit In response to a report of precancerous changes in the pancreases of rats and organ donors treated with the DPP-4 inhibitor sitagliptin,[24][25] the United States FDA and the European Medicines Agency each undertook independent reviews of all clinical and preclinical data related to the possible association of DPP-4 inhibitors with pancreatic cancer. In a joint letter to the New England Journal of Medicine, the agencies stated that they had not yet reached a final conclusion regarding a possible causative relationship.[26] A 2014 meta-analysis found no evidence for increased pancreatic cancer risk in people treated with DPP-4 inhibitors, but owing to the modest amount of data available, was not able to completely exclude possible risk.[27] Combination drugsEdit Some of the DPP-4 inhibitor drugs have gotten approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production.[28]

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In today’s episode, we explore the highly popular topic of Ozempic and other weight loss medications that are currently gaining attention for their dramatic effects on weight loss. We’ll dive deep into whether Ozempic is the right choice for your weight loss journey, and weigh the benefits versus potential risks. If you're considering taking weight loss drugs like Ozempic or similar alternatives, this episode provides key insights into how these medications work, the long-term effects, and the importance of maintaining your overall health while using them. Discover how Ozempic and similar drugs can cause rapid weight loss, but also what’s at stake when it comes to muscle mass loss, metabolism slowing down, and the psychological impact on your eating habits and mindset. I’ll discuss how to minimise muscle loss and maintain a healthy metabolism through resistance training and high-protein diets. Understanding these factors can make a big difference in achieving sustainable weight loss and maintaining your results after coming off these medications. Throughout this podcast, we’ll cover the following topics: * Why Ozempic has become a hot topic in the weight loss industry * The importance of muscle retention during weight loss treatments * The long-term side effects of using weight loss medications * How to make behavioral changes to support your weight loss journey * How protein intake and resistance training are critical for minimizing muscle loss * The importance of informed decision-making and evaluating if Ozempic is right for you With many celebrities promoting weight loss drugs, it’s crucial to separate fact from fiction. The key is to make informed choices and understand the long-term health implications before starting any new weight loss medication. If you’re considering Ozempic, or are just curious about weight loss drugs in general, this episode offers valuable insights into healthy weight loss strategies that can lead to long-term success. Resistance training, protein-based diets, and behavioral change are just as important as the drugs themselves in achieving the best outcomes for your body. Disclaimer: The information shared in this podcast is for educational purposes only and is not intended as medical advice. Please consult with a healthcare professional before making any changes to your medication or health routine. SUBSCRIBE and FOLLOW our social media accounts below where you can find DAILY tips for the 40. https://www.facebook.com/thedvcc https://www.instagram.com/thetraininggyms/ https://www.linkedin.com/company/3604961/

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Semaglutide is a medication that has gained popularity in recent years for its effectiveness in helping individuals lose weight. Originally approved for the treatment of type 2 diabetes, semaglutide has now been approved for weight management in individuals who are overweight or obese. Many people have reported significant weight loss results while taking semaglutide, but it is essential to understand what average weight loss results you can expect when using this medication.

How Semaglutide Works

Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by mimicking the effects of a hormone called GLP-1 that is naturally produced in the body. GLP-1 helps to regulate appetite, food intake, and blood sugar levels. By activating the GLP-1 receptors, semaglutide helps to reduce hunger and increase feelings of fullness, which can lead to reduced calorie intake and ultimately weight loss.

In addition to its effects on appetite regulation, semaglutide also slows down the emptying of the stomach and reduces the absorption of glucose from the intestines. This can help to stabilize blood sugar levels and decrease insulin resistance, which are important factors in managing weight and reducing the risk of developing obesity-related health conditions.

Average Weight Loss Results

Studies have shown that individuals taking semaglutide for weight management can achieve significant weight loss results. On average, people taking semaglutide have been able to lose anywhere from 5% to 15% of their initial body weight over a period of several months. The amount of weight loss can vary from person to person, but many individuals have reported losing a substantial amount of weight while taking this medication.

It is essential to note that weight loss results may not be immediate and can vary depending on factors such as diet, exercise, and individual metabolism. Some people may see rapid weight loss in the first few weeks of taking semaglutide, while others may experience a slower and more gradual decrease in weight over time. It is essential to be patient and consistent with taking the medication as prescribed to see the best results.

Potential Side Effects

While semaglutide can be an effective tool for weight loss, like any medication, it can come with potential side effects. Some common side effects of semaglutide include nausea, vomiting, diarrhea, and constipation. These side effects are usually mild to moderate in severity and tend to improve over time as the body adjusts to the medication. It is essential to talk to your healthcare provider if you experience any persistent or severe side effects while taking semaglutide.

In rare cases, semaglutide can also cause more serious side effects such as pancreatitis or kidney problems. It is crucial to be aware of the potential risks and benefits of taking semaglutide and to discuss any concerns with your healthcare provider before starting this medication. Your healthcare provider can help you determine if semaglutide is the right choice for you based on your individual health needs and goals.

Lifestyle Changes

While semaglutide can be a helpful tool for weight loss, it is essential to remember that it is not a magic solution. To achieve the best results, it is important to combine the medication with healthy lifestyle changes such as a balanced diet and regular exercise. Making sustainable changes to your eating habits and physical activity levels can help to support the weight loss effects of semaglutide and improve your overall health and well-being.

It is also essential to work closely with your healthcare provider while taking semaglutide to monitor your progress and make any necessary adjustments to your treatment plan. Your healthcare provider can provide guidance and support to help you reach your weight loss goals safely and effectively while taking semaglutide. By combining the medication with lifestyle changes and ongoing support from your healthcare team, you can maximize the benefits of semaglutide for weight management.

Overall, semaglutide can be an effective option for individuals looking to lose weight and improve their health. By understanding how semaglutide works, the average weight loss results you can achieve, potential side effects, and the importance of lifestyle changes, you can make informed decisions about using this medication as part of your weight management plan. If you have any questions or concerns about semaglutide, be sure to talk to your healthcare provider for personalized advice and recommendations.

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Dr. Gerald Haas, director of LJCSC’s Signature Skinny Shot medical weight loss program, reveals the key differences between semaglutide and tirzepatide medications. He gives us the inside scoop on how he chooses one over the other for patients and why he might switch medications for patients at any point in their journey. Check out our full podcast episode on the skinny shot to learn more https://youtu.be/helFk9MayXc Learn how to give yourself the Signature Skinny Shot https://youtube.com/shorts/IjNc0hOuf28?feature=share

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