Transcript 12 Kgs Weight Loss At Home Plan Link In BioThis Harvard Medical School Continuing Education video examines these key questions: When should GLP-1 receptor agonists be used for weight loss and in what dosage? What cautions should physicians be aware of when prescribing GLP-1 RA? Dr. Lee-Shing Chang, MD, an endocrinologist at Brigham and Women’s Hospital in Boston, Massachusetts, reviews the medical indications and side effects of GLP-1 receptor agonists when used for weight loss. Dosing and administration are discussed and contraindications including pregnancy, retinopathy, and hypoglycemia are highlighted. 00:00 | Introduction 00:38 | Indications and contraindications for liragutide and semaglutide in weight loss 03:56 | Administration and dosing of GLP-1 receptor agonists 06:15 | Gastrointestinal side effects of GLP-1 receptor agonists 07:41 | Future directions for GLP-1 receptor agonists This video was peer reviewed by Dr. Jonathan Salik, TMD, MHPEd, Instructor of Medicine, Massachusetts General Hospital; and Dr. Sugantha Sundar, MD, Assistant Professor of Anesthesia, Beth Israel Deaconess Medical Center, to validate the quality and accuracy of the content. References: Muskiet MHA, Tonneijck L, Smits MM, et al. GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes. Nat Rev Nephrol. 2017;13(10):605-628. doi:10.1038/nrneph.2017.123 Pi-Sunyer X, Astrup A, Fujioka K, et al. A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management. N Engl J Med. 2015;373(1):11-22. doi:10.1056/NEJMoa1411892 Wilding JPH, Batterham RL, Calanna S, et al. Once-Weekly Semaglutide in Adults with Overweight or Obesity. N Engl J Med. 2021;384(11):989. doi:10.1056/NEJMoa2032183 Rubino DM, Greenway FL, Khalid U, et al. Effect of Weekly Subcutaneous Semaglutide vs Daily Liraglutide on Body Weight in Adults With Overweight or Obesity Without Diabetes: The STEP 8 Randomized Clinical Trial. JAMA. 2022;327(2):138-150. Rubino D, Abrahamsson N, Davies M, et al. Effect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial. 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Are there any specific exercises to target belly fat? MuscleBlaze Biozyme Performance PR Whey [use code 'BIGMAN"]: https://www.muscleblaze.com/sv/muscleblaze-biozyme-performance-whey-pr/SP-122029 1 - on - 1 Online Coaching: https://shopbigman.in/online-coaching My Ultimate Fat Loss and Muscle Building Transformation Program : https://shopbigman.in/workout-program The Ultimate Fat Loss Cookbook: https://shopbigman.in/cookbook My Instagram: https://www.instagram.com/okaymohit Many people think that exercising automatically leads to losing fat, but this idea can be deceptive for various reasons. Let's delve into the important aspects to keep in mind: 1. Caloric Intake: Losing fat depends on finding the right balance between the calories you eat and the calories you burn. Exercise helps burn calories, but keep in mind that exercising alone may not be enough. If you work out intensely but then eat more, your overall calorie balance might not change much, leading to minimal fat loss. 2. Nutrition: Your diet plays a crucial role in managing weight. While exercise contributes to burning calories, what and how much you eat has a big impact on fat loss. Having a balanced and nutritious diet with the right amounts of proteins, carbohydrates, and fats is key. Without paying attention to your eating habits, relying solely on exercise may not result in significant fat loss. 3. Muscle vs Fat: Exercise can change your body composition, but it doesn't always mean losing overall weight. Since muscle is denser than fat, building muscle might make your weight stay the same or even increase. However, you could still see a decrease in body fat percentage and a more toned look. So, focusing only on the scale without considering body composition can be misleading. 4. Metabolic Adaptation: The body is smart and adapts to exercise. If you stick to the same routine, your body becomes more efficient at using energy, and you may burn fewer calories over time. To keep challenging your body and avoid hitting a plateau in fat loss, mix up the intensity, duration, and types of exercises. 5. Individual Variability: Everyone responds differently to exercise due to factors like genetics, hormones, and lifestyle. What works wonders for one person might not have the same effect on another. Some may see quick fat loss with exercise, while others make progress at a slower pace. Recognizing these individual differences is important when talking about exercise and fat loss. In conclusion, exercise is a vital part of a healthy lifestyle and can contribute to fat loss. However, it's essential to consider the bigger picture. Fat loss is a complex process influenced by diet, calorie balance, body composition changes, metabolic adaptations, and individual variability. Relying solely on exercise for fat loss is an oversimplified approach. To achieve sustainable and long-term goals, it's crucial to adopt a holistic approach that combines exercise with proper nutrition and other lifestyle factors. Music track: Sunset by Lukrembo Source: https://freetouse.com/musicSafeline Ketos Strategic Move To Shark Tank Impact And Outcomes❗Обязательно прочитайте👇🏻 Признавайтесь, кто поверил? Только честно) Мuф о "жиросжигающем ананасе" родился из открытия в ананасе протеолитического фермента БРОМЕЛАЙНА: его способность расщеплять белок и “размягчать мясо” маркетологи и журналисты некорректно экстраполировали на “растворение” жира в теле. Во второй половине XX века появлялись “ананасовые диеты” и добавки с бромелайном, где способность помогать переваривать белок с какого-то перепугу выдавали за ускорение обмена веществ и сжигание жира 😁 Что сказать, мapkeтuнг. Коммерческая pekлaмa (в т. ч. “ананасовые таблетки для пoxyдeнuя”) в 1990-е–2000-е) закрепила мuф, хотя бромелайн НЕ РАСЩЕПЛЯЕТ ЖИР и в обычных дозах не влияет на массу тела. Вообще, ананас как бы ЗАЩИЩАЕТСЯ от нас, чтобы его не кушали)) Поэтому за счёт бромелайна он пытается расщепить белок нашего рта и кишечника, сделав нам бoлbно. Поэтому, если наесться ананаса, может пощипывать щёки и губы. Но это не вредно и быстро проходит. Зато в целом этот бромелайн - полезная штука. Правда, в самом ананасе его мало для полезных эффектов. Поэтому используют виде добавок. В клинических исследованиях бромелайн умеренно помогал быстрее сходить отёку и боли после oпepaцuй, тpaвм, при синусите и частично при болях в колене (остеоартрит). Механизм — расщепление белковых “мостиков” (фибрина), снижение воспаления и проницаемости сосудов, поэтому меньше воспалительной жидкости. Но возможны взаимодействия с кровожающими препаратами — стоит обсудить с врачом. Но, к сожалению, в теме снижения вecа снова волшебной пилюли снова не случилось. Сорри, если кого-то разочаровал. 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