Transcript Power Keto Gummies Boosting Your Keto Diet With Potent SupplementsMaster the pharmacology of diabetes treatments with this comprehensive medical lecture. Designed for medical students, pharmacy students, physicians, pharmacists, and nurses, this session covers the mechanisms of action, effects, side effects, and clinical considerations for major classes of anti-diabetic drugs, including sulfonylureas, metformin, TZDs, DPP-4 inhibitors, GLP-1 receptor agonists, SGLT2 inhibitors, and insulin. This in-depth lecture explores critical aspects of diabetes pharmacology, including: [00:14] Sulfonylureas (SUs): [02:26] Mechanism: Stimulating insulin secretion via ATP-sensitive K+ channel blockade. [04:31] Side Effects: Hypoglycemia, weight gain. [08:47] Meglitinides: Similar insulin secretagogue action, different binding site, [09:43] short-acting. [14:16] Metformin (Biguanides): Mechanism: Reducing hepatic glucose production. [22:56] Side Effects: GI disturbances, lactic acidosis risk. [25:25] Thiazolidinediones (TZDs / Glitazones): Mechanism: PPAR gamma agonists, increasing insulin sensitivity. [30:15] Side Effects: Weight gain, edema. Incretin-Based Therapies: [33:09] GLP-1 Physiology: Origin from preproglucagon. [37:04] DPP-4 Inhibitors: Mechanism (increase endogenous GLP-1 levels). [39:25] GLP-1 Receptor Agonists (GLP-1 RAs): Examples (Semaglutide, Liraglutide); [38:57] Side effects (nausea, vomiting). [47:59] SGLT2 Inhibitors: Mechanism: Increasing urinary glucose elimination. [52:26] Side Effects: UTIs, genital infections. [53:07] Alpha-glucosidase Inhibitors: Mechanism: Reducing carbohydrate absorption. [53:57] Side Effects: Flatulence, diarrhea. [54:41] Pramlintide (Amylin Analog): Mechanism (reduces gastric motility & glucagon secretion). [56:24] Bromocriptine: Dopamine receptor agonist used for glucose lowering. [57:26] Insulin: Role in Type 2 Diabetes management. Key Learning Objectives: Understand the mechanisms of action for major classes of anti-diabetic medications. Identify common and significant side effects associated with each drug class. Differentiate between various diabetes drug classes based on their primary targets and effects (e.g., insulin secretagogues, sensitizers, incretin-based, glucose excretion enhancers). Appreciate the pharmacological basis for choosing different therapies in diabetes management. SANTINIKETAN MEDICAL COLLEGE & HOSPITAL Real Classroom Demonstration/Lecture On: PHARMACOLOGY by Dr. Neeladri Majumder (MBBS Batch: 2023-24) Conducted on: 03-04-25New Kiss My Keto Bread Gummies Review Discount Code UniqueUse Code THOMAS for 20% off Anything from Kettle & Fire: https://www.kf91trk.com/BXCXC4/9B9DM/ These are the Supplements I Take This video does contain a paid partnership with a brand that helps to support this channel. 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Metz’s journey began against the backdrop of personal struggles, societal expectations, and the challenges that come with fame in the entertainment industry. Born on September 29, 1980, in Ocala, Florida, Metz faced her share of challenges growing up. A combination of family dynamics, self-image issues, and the pressures of the performance industry led her to a complex relationship with food and body image. Despite her struggles, she used these experiences to fuel her artistic endeavors, paving the way for a successful career that resonates with many who might face similar trials in their lives. However, as she became a household name, the spotlight brought both support and scrutiny regarding her weight. Metz’s turning point came when she decided to prioritize her health, driven by a desire to live fully and authentically. Her weight loss journey is not merely about numbers on a scale; it’s a profound commitment to changing her lifestyle for the better. Through her story, she encourages others to take charge of their lives, embracing the idea that wellness can manifest in many forms. Her narrative has sparked important conversations about body image, self-acceptance, and the importance of mental health in tandem with physical health. As she shares her journey, Metz continues to inspire others to recognize that transformation often involves a deeper emotional and psychological journey. Understanding the Motivations Behind Her Weight Loss A pivotal aspect of Chrissy Metz’s weight loss journey is understanding her motivations. Initially, the actress found herself pressured by societal standards of beauty and success. The expectation that public figures should conform to a specific image can be overwhelming, especially in the age of social media, where comparisons are rampant. Metz has spoken candidly about the emotional turmoil she faced due to constant scrutiny over her weight, leading her to rethink her approach to health and wellness. What is particularly compelling about Metz’s motivations is her capacity to turn this pressure into a source of strength. Instead of succumbing to the negative influences of societal expectations, she transformed her narrative into one of empowerment. She became motivated not just by a desire to lose weight but to regain control over her life. This awakening led her to recognize that true beauty lies in self-acceptance and not in fitting into predefined molds. This mindset shift is remarkable and has served as a cornerstone of her journey, encouraging others to seek their own paths to wellness. Additionally, Metz’s motivations extend into her commitment to physical health, which she realized is interconnected with mental and emotional well-being. She began incorporating healthy eating and exercise routines into her life, emphasizing balance rather than restriction. This holistic approach manifested in her discussions and efforts, demonstrating that motivation can stem from a desire for overall well-being rather than just meeting external expectations. Through her story, Metz inspires many to find their meaning of health and transformation, establishing that the journey can be deeply personal. Challenges Faced Along the Journey No journey is without its challenges, and Chrissy Metz’s path to wellness is no exception. From battling temptations to managing fluctuating results, Metz has faced numerous obstacles that could have derailed her efforts. One major challenge has been the psychological battle that accompanies weight loss. She has openly shared her experiences, including moments of frustration, self-doubt, and the temptation to revert to unhealthy habits during tough times. Moreover, there are the external challenges that came with her public persona. As a celebrity, Metz has faced the scrutiny of fans and critics alike, adding additional pressure to her journey. Navigating such an environment requires immense resilience and self-belief, and Metz has had to constantly remind herself of her motivations—to prioritize her health and happiness above all else. This pressure can be debilitating for many, and Metz’s honesty illustrates the importance of mental health support during weight loss and self-improvement journeys. Lifestyle changes are rarely linear, and Metz’s journey reflects this reality with all its ups and downs. There were times when she faced setbacks, not just in terms of weight loss but also regarding motivation and energy levels. She candidly describes how she had to learn to be kind to herself during difficult days, understanding that progress may not always look as expected. Embracing imperfection has been essential in sustaining her long-term commitment to health, setting an example for others that it is perfectly acceptable to face challenges while pursuing an aspirational goal. Support Systems: Friends, Family, and Therapy As with many transformative journeys, support systems play a crucial role in Chrissy Metz’s progress. Building a network of supportive figures, including family, friends, and professionals, has been instrumental in her path to wellness. Metz has consistently emphasized the importance of surrounding oneself with positivity and encouragement. This has meant leaning on close family and friends who understand her journey and provide emotional support during challenging times. Additionally, Metz has championed the importance of seeking professional help. Therapy has been a significant part of her journey, helping her navigate the psychological aspects of weight loss and self-acceptance. This willingness to embrace both personal and professional assistance highlights her understanding that mental health is just as crucial as physical health. It allows her to address deep-seated issues that could sabotage her progress while fostering a positive mindset. Through her transparency about the importance of support, Metz encourages her audience to seek help in whatever form they need. She emphasizes that needing helping hands is not a sign of weakness but, rather, a crucial step toward achieving personal health and growth. The camaraderie found in sharing experiences with loved ones can empower someone on a similar journey, reminding them that they are not alone in their struggles and successes. Inspiring Others: Chrissy’s Impact on Body Positivity Chrissy Metz has become a beacon of hope for many, particularly in the realms of body positivity and self-acceptance. Her role on “This Is Us” brought her story to the forefront, showcasing the importance of representation in media for individuals of all shapes and sizes. By taking on her character’s struggles, Metz has used her platform to highlight the everyday challenges faced by those who do not fit into traditional beauty standards. This visibility has contributed to a broader movement toward embracing diverse bodies in entertainment. Beyond her on-screen roles, Metz’s real-life journey promotes an essential message: that self-love and acceptance are critical components of well-being. By sharing her experiences with vulnerability, she inspires others to embrace their bodies, regardless of societal pressures. Her conversations around body image resonate deeply, encouraging individuals to recognize their inherent worth and beauty. This dialogue fosters understanding, breaking down barriers and educating the public on the importance of compassion and acceptance, both for themselves and others. Moreover, Metz’s impact extends into activism and philanthropy. She has participated in campaigns promoting mental health awareness, aiming to destigmatize seeking help for emotional struggles. By marrying her personal narrative with advocacy, she encourages individuals to address their mental health alongside physical health in pursuit of holistic well-being. In doing so, Metz has solidified her position not just as an actress but as a role model for individuals seeking a similar transformation and affirming that their journeys—like hers—can lead to profound personal growth. Final Thoughts and Information for Aspiring Transformers Chrissy Metz’s weight loss journey serves as a powerful reminder that transformation encompasses much more than physical changes. Her story illustrates the complexity of undertaking such a journey, filled with emotional battles, support systems, and standing against societal pressures. For individuals inspired by Metz’s path, it’s essential to understand that every journey is unique, and what works for one person may not work for another. For those seeking to embark on their transformations, it’s valuable to first establish clear motivations grounded in a desire for health, happiness, and self-acceptance. Setting realistic goals and recognizing that setbacks are part of the process can aid one’s journey. Seeking support from friends, family, or professionals can make a significant difference in sustaining motivation and navigating challenges that may arise. In conclusion, Metz’s journey exemplifies the power of resilience, grace, and authenticity. It encourages individuals around the world to pursue their health and well-being unapologetically, reminding them that every step of the journey contributes to a larger narrative of self-discovery and acceptance. 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