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In this video Doctor O'Donovan explains key facts you need to know about a medication called METFORMIN used to treat type 2 diabetes (also known as Glucophage, Fortamet, Axpinet, Diagemet, Glucient, Metabet). In the video we cover: What is metformin? (0.36) Who can and can't take it? (1.34) How to take it (2.36) Side effects (4.49) Use in pregnancy (7.40) Interactions (8.15) Key facts - Not everyone gets diabetes symptoms, so taking metformin may not make you feel any different. That does not mean it is not working, so keep on taking it. - It's best to take metformin with a meal to reduce the side effects. The most common side effects are feeling and being sick, diarrhoea, stomach ache and loss of appetite. Vitamin B12 deficiency is also a common side effect of taking metformin in higher doses or for long periods. - Metformin does not cause weight gain, unlike some other diabetes medicines. - If you have diabetes, you can get free prescriptions for all of your medicines, not just your diabetes ones. You'll need to have a medical exemption certificate. Further information via NHS website: https://www.nhs.uk/medicines/metformin/ Patient information leaflet: https://www.medicines.org.uk/emc/product/594/pil #doctor #diabetes #medication #pharmacy ************************************************************************ Connect through: YouTube: www.youtube.com/doctorodonovan​ TikTok: @doctorodonovan ************************************************************************** Disclaimer: The video is intended as an educational resource only. The information within this video or on this channel isn't designed to replace professional input, so if you have any medical issues please consult a medical provider. No professional relationship is being created by watching this video. Dr. O’Donovan cannot give any individual medical advice. All information should be verified for accuracy by the individual user. Dr O’Donovan accepts no responsibility for individual interpretation of data, although it is always accurate to the best of his knowledge at the time of the video being published. This is an EDUCATIONAL video. Images are used in accordance with fair use guidelines. Legal information: Content provided via YouTube is for general information purposes ONLY. Information videos are not produced to provide individualised medical advice. Medical education videos on Doctor O'Donovan are not a substitute for professional professional medical advice, diagnosis or treatment. NEVER ignore professional medical advice because of something you have heard here. ALWAYS consult your doctor regarding any concerns about your condition or treatment.

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On World Obesity day, let us demystify myths around obesity! Five decades ago/ Pre 1980’s era, Obesity, type 2 diabetes & other metabolic diseases were a rare phenomenon. Our grandparents never had obesity- & they never had these fad recommendations of high protein, low carb & more but they had one aspect of our biology which we miss out now- balanced & diverse gut microbiome. No brainer- the foods they ate were rich in fibre & polyphenols which were food for their microbiome. Their gut microbes synthesised these food substrates & converted them into short chain fatty acids which secreted GLP-1- the hormone required to regulate our metabolism, satiety & appetite. GLP-1 communicates with Pancreas to regulate blood sugar response & communicates with the brain to modulate our hunger responses. Besides, our gut microbiome can make it hard to lose weight by 1.Low Grade Chronic Inflammation : Synthesising foods, not compatible with our biology, into pro-inflammatory metabolites such as LPS, TMAO & more which when released into the blood stream triggers inflammatory responses. In other words, this leads to high fat storage & low fat export. 2.Gut-Brain Axis: Gut communicates with the brain via Vagus nerve & impact hunger responses by impacting production of ghrelin, leptin & other hunger hormones. 3.If gut microbiome is less diverse, not producing enough enzymes or have now butyrate producing bacteria, it could stimulate hunger However, corporatization of foods & fad diets such as high protein & quantified nutrition has changed the entire microbial ecosystem inside our body triggering a wave of chronic inflammation. One of the most important reasons for obesity is degradation of GLP-1 which is caused by multiple metabolic pathways including those impacted by gut & oral microbiome. However, GLP-1 drugs being marketed as the solution for metabolic issues, leaves a lot of questions unanswered as it does not address the root cause- gut microbial dysbiosis. Besides, it brings its share of side effects & collateral damage including gastrointestinal issues- diarrhoea, bloating, constipation & more, loss of healthy muscle mass loss, inflammation of pancreas & even high risk of pancreatic cancer. Today's video discusses the role of gut & oral microbiome in obesity & each of the pathways associated with degradation of GLP-1 as well as what could make GLP-1 drugs ineffective & harmful Citations below https://diabetesjournals.org/care/article/33/2/453/27096/GLP-1-Based-Therapy-for-Diabetes-What-You-Do-Not https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10391832/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112002/ https://dom-pubs.pericles-prod.literatumonline.com/doi/10.1111/dom.14725 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5082693/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5187364/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3266401/ https://pubmed.ncbi.nlm.nih.gov/23892476/ https://pubmed.ncbi.nlm.nih.gov/22506074/ https://www.nature.com/articles/s41598-018-20549-0

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