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Professor Barry Borlaug presents the SUMMIT trial on the use of the GIP / GLP-1 receptor dual agonist in patients with obesity-associated Heart-Failure with Preserved Ejection Fraction, which has been published in New Engl J Med 2024 and elected the most important study in cardiology and lipidology 2024 by MARKUS at HOMe. Dr. Borlaug is Professor of Medicine and Director, Circulatory Failure Research, Division of Cardiovascular Diseases, and Chair for Research, Division of Circulatory Failure, Department of Cardiovascular Medicine at the Mayo Clinic, Rochester, Minnesota. He is a global leader in studies on mechanisms, diagnosis and treatment of heart failure, particularly heart failure with preserved ejection fraction (HFPEF). The interview was recorded on January 16th, 2025. Moderators: Prof. Dr. Dr. Stephan Schirmer (Kaiserslautern, Germany), Prof. Dr. Florian Custodis (Saarbrücken, Germany) and Prof. Dr. Gunnar Heine (Frankfurt, Germany). Articles discussed: GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders. Leggio L, Hendershot CS, Farokhnia M, Fink-Jensen A, Klausen MK, Schacht JP, Simmons WK. Nat Med 2023 doi: 10.1038/s41591-023-02634-8 Tirzepatide Reduces LV Mass and Paracardiac Adipose Tissue in Obesity-Related Heart Failure: SUMMIT CMR Substudy. Kramer CM, Borlaug BA, Zile M MR, Ruff D, DiMaria JM, Menon V, Ou Y, Zarante AM, Hurt KC, Murakami M, Packer M; SUMMIT Trial Study Group. J Am Coll Cardiol 2024 doi: 10.1016/j.jacc.2024.11.001 Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity. Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, Ge J, Weerakkody GJ, Ou Y, Bunck MC, Hurt KC, Murakami M, Borlaug BA; SUMMIT Trial Study Group. N Engl J Med 2024 doi: 10.1056/NEJMoa2410027 Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial. Borlaug BA, Zile MR, Kramer CM, Baum SJ, Hurt K, Litwin SE, Murakami M, Ou Y, Upadhyay N, Packer M. Nat Med 2024 doi: 10.1038/s41591-024-03374-z Evidence Supporting the Existence of a Distinct Obese Phenotype of Heart Failure With Preserved Ejection Fraction. Obokata M, Reddy YNV, Pislaru SV, Melenovsky V, Borlaug BA. Circulation 2017 doi: 10.1161/CIRCULATIONAHA.116.026807 An evidence-based screening tool for heart failure with preserved ejection fraction: the HFpEF-ABA score. Reddy YNV, Carter RE, Sundaram V, Kaye DM, Handoko ML, Tedford RJ, Andersen MJ, Sharma K, Obokata M, Verbrugge FH, Borlaug BA. Nat Med 2024 doi: 10.1038/s41591-024-03140-1 A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction. Reddy YNV, Carter RE, Obokata M, Redfield MM, Borlaug BA. Circulation 2018 doi: 10.1161/CIRCULATIONAHA.118.034646 How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Pieske B, Tschöpe C, de Boer RA, Fraser AG, Anker SD, Donal E, Edelmann F, Fu M, Guazzi M, Lam CSP, Lancellotti P, Melenovsky V, Morris DA, Nagel E, Pieske-Kraigher E, Ponikowski P, Solomon SD, Vasan RS, Rutten FH, Voors AA, Ruschitzka F, Paulus WJ, Seferovic P, Filippatos G. Eur J Heart Fail 2020 doi: 10.1002/ejhf.1741 Dapagliflozin Enhances Arterial and Venous Compliance During Exercise in Heart Failure With Preserved Ejection Fraction: Insights From the CAMEO-DAPA Trial. Tada A, Burkhoff D, Naser JA, Harada T, Pourmussa B, Reddy YNV, Jensen MD, Carter RE, Demmer RT, Testani JM, Chirinos JA, Borlaug BA. Circulation 2024 doi: 10.1161/CIRCULATIONAHA.124.068788 Cardiac and Metabolic Effects of Dapagliflozin in Heart Failure With Preserved Ejection Fraction: The CAMEO-DAPA Trial. Borlaug BA, Reddy YNV, Braun A, Sorimachi H, Omar M, Popovic D, Alogna A, Jensen MD, Carter R Circulation 2023 doi: 10.1161/CIRCULATIONAHA.123.065134

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When it comes to weight loss, there are various medications and treatments available in the market. Two popular options for weight loss are Ozempic and Semaglutide. Both medications are injectable glucagon-like peptide-1 receptor agonists that have been approved by the FDA for the treatment of obesity. While they belong to the same class of drugs, there are differences in their effectiveness and usage. In this article, we will compare the effectiveness of Ozempic vs Semaglutide for weight loss.

Ozempic

Ozempic, also known as semaglutide, is a once-weekly injectable medication that is used to improve blood sugar levels in adults with type 2 diabetes. It works by mimicking the effects of a hormone called glucagon-like peptide-1 (GLP-1), which helps regulate blood sugar levels and reduce appetite. In addition to its benefits for diabetes management, Ozempic has also been found to be effective for weight loss in clinical trials.

One of the key benefits of Ozempic is its ability to suppress appetite and reduce food intake. This can lead to a decrease in calorie consumption, which is essential for weight loss. In clinical studies, Ozempic has been shown to help patients lose significant amounts of weight when used in conjunction with a healthy diet and exercise routine. Some patients may experience mild side effects such as nausea or diarrhea, but these symptoms usually subside over time.

Another advantage of Ozempic is its convenience. Since it is a once-weekly injection, patients do not have to worry about taking multiple doses throughout the day. This can make it easier for individuals to adhere to their weight loss plan and stay on track with their treatment. Additionally, Ozempic has been found to have a positive impact on cardiovascular health, reducing the risk of heart disease and stroke in patients with type 2 diabetes.

Semaglutide

Semaglutide, on the other hand, is a daily injectable medication that is used to treat type 2 diabetes and obesity. It works in a similar way to Ozempic by increasing the levels of GLP-1 in the body, which can help control blood sugar levels and reduce appetite. Semaglutide has been shown to be effective for weight loss in clinical trials and is often prescribed off-label for this purpose.

One of the main advantages of Semaglutide is its potent effect on weight loss. In studies, Semaglutide has been found to help patients lose more weight compared to other weight loss medications. This can be particularly beneficial for individuals who have struggled to lose weight with diet and exercise alone. However, Semaglutide may cause more gastrointestinal side effects compared to Ozempic, such as nausea, vomiting, or constipation.

Another benefit of Semaglutide is its flexibility in dosing. Since it is a daily injection, patients can adjust their dose based on their individual needs and preferences. This can be helpful for individuals who may need more or less medication to achieve their weight loss goals. Additionally, Semaglutide has also been shown to have a positive impact on cardiovascular health, reducing the risk of heart disease and stroke in patients with obesity.





Comparison

When comparing Ozempic vs Semaglutide for weight loss, both medications have been found to be effective in helping patients lose weight when used in conjunction with a healthy diet and exercise routine. However, there are some differences between the two drugs that may influence the choice of treatment for individual patients.

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Overall, the choice between Ozempic and Semaglutide will depend on the individual patient’s preferences and medical history. Both medications can be effective for weight loss, but the dosing schedule, side effects, and cost may vary between the two drugs. It is important to consult with a healthcare provider to determine the best treatment option for your specific needs and goals.

In conclusion, both Ozempic and Semaglutide are effective medications for weight loss in adults with type 2 diabetes and obesity. They work by increasing the levels of GLP-1 in the body, which can help control blood sugar levels and reduce appetite. While both medications have been found to be effective for weight loss, there are differences in their dosing schedule, side effects, and cost that may influence the choice of treatment for individual patients. Consult with a healthcare provider to determine the best option for your specific needs and goals.

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When it comes to weight loss medications, Semaglutide has been gaining popularity as an effective option for individuals struggling to shed excess pounds. This injectable medication works by regulating appetite and promoting feelings of fullness, leading to reduced caloric intake and, ultimately, weight loss. However, one common question that arises among those considering Semaglutide treatment is whether it is safe to consume alcohol while taking this medication.

Key Considerations

Before reaching for that glass of wine or bottle of beer, it’s essential to understand how alcohol interacts with Semaglutide and what potential risks may be involved. Here are some key considerations to keep in mind:

Impact on Blood Sugar Levels

One potential concern with consuming alcohol while taking Semaglutide is the impact it can have on blood sugar levels. Alcohol is known to lower blood sugar, which can be problematic for individuals with diabetes or those at risk of hypoglycemia. When combined with Semaglutide, which also has effects on blood sugar levels, the interaction can potentially lead to dangerous fluctuations in glucose levels.

Effect on Weight Loss Goals

Alcohol is high in empty calories and can sabotage weight loss efforts if consumed in excess. When trying to lose weight with Semaglutide, it’s important to be mindful of the additional calories and potential lack of nutritional value that alcohol can contribute. By indulging in alcoholic beverages, you may be hindering your progress and making it harder to reach your weight loss goals.

Gastrointestinal Side Effects

Both Semaglutide and alcohol can have gastrointestinal side effects, such as nausea, vomiting, and diarrhea. When combined, these side effects may be exacerbated, leading to discomfort and potential complications. It’s important to monitor how your body reacts to the combination of Semaglutide and alcohol and speak with your healthcare provider if you experience any concerning symptoms.





Liver Function

Alcohol is processed by the liver, and excessive alcohol consumption can lead to liver damage and dysfunction. Since Semaglutide is also metabolized in the liver, combining the medication with alcohol may place additional strain on this vital organ. Individuals with underlying liver conditions or those at risk of liver problems should exercise caution when consuming alcohol while taking Semaglutide.

Interactions with Other Medications

If you are taking Semaglutide along with other medications, it’s important to consider how alcohol may interact with these drugs. Alcohol can interfere with the effectiveness of certain medications or amplify their side effects, leading to potential health risks. Before drinking alcohol while on Semaglutide, consult with your healthcare provider to ensure that it is safe to do so.

Summary

In conclusion, while occasional moderate alcohol consumption may not pose significant risks for individuals taking Semaglutide for weight loss, it’s essential to be cautious and mindful of the potential interactions and complications that may arise. By understanding the key considerations mentioned above and consulting with your healthcare provider, you can make informed decisions regarding alcohol consumption while on Semaglutide treatment.

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00:00 Intro Story 00:47 Intro 01:22 What is overweight and Obesity? 02:16 Burden of obesity 02:52 Diseases associated with Obesity 03:11 Difficulties of losing weight 04:18 How these weight loss medicines work? Semaglutide , Ozempic , Mounjaro 05:45 How long it will take to lose weight? 06:35 Who are all benefit from these weight loss medicines? 7:36 Other health benefits of these weight loss medications 08:20 Side effects of weight loss medications 09:21 How long we should take weight loss medications? 10:18 Do I gain weight after stopping these weight loss medications? 10:44 Cost of these medications in India 12:10 Quick tips 13:12 Outro Join me as I dive into the world of Ozempic and Mounjaro to see if they really live up to the hype for weight loss! Ozempic and Mounjaro are two medications that have been gaining popularity in the weight loss market, and many people are wondering if they can really help them achieve their weight loss goals. Obesity and weight management are challenges that many individuals face, and it's an issue that affects not just physical health, but also mental wellbeing. Millions of people struggle with excess weight, and it's a major risk factor for chronic diseases like diabetes, heart disease, and certain types of cancer. The emotional toll of being overweight can be just as damaging as the physical, leading to low self-esteem and a lack of confidence. Finding effective solutions to weight loss is crucial, as it can greatly improve overall health and quality of life. Many people have tried various diets and exercise programs, but they often end up feeling frustrated and disappointed with the results. The mechanisms behind Ozempic and Mounjaro are quite complex, but essentially they work by mimicking hormones in the body that help regulate blood sugar levels and appetite. Ozempic, also known as semaglutide, has been shown in clinical studies to be highly effective in promoting weight loss, with some participants losing up to 10% of their body weight. Mounjaro, or tirzepatide, has also demonstrated impressive results, with significant weight loss and improvements in blood sugar control. As with any medication, there are potential side effects to consider, such as nausea, vomiting, and increased risk of pancreatitis. Research on Ozempic and Mounjaro has been extensive, with numerous clinical trials demonstrating their safety and efficacy. The results are quite impressive, with many participants achieving significant weight loss and improvements in their overall health. For example, one study found that participants taking Ozempic lost an average of 15% of their body weight over a period of 68 weeks. Another study on Mounjaro showed that participants achieved an average weight loss of 20% over a period of 72 weeks. These medications have the potential to revolutionize the way we approach weight loss, offering a new hope for those who have struggled with traditional methods. Many people have already started using Ozempic and Mounjaro, and the results are nothing short of amazing. Some have reported losing large amounts of weight in a short period of time, while others have seen significant improvements in their blood sugar control and overall health. The success stories are numerous, and they're a testament to the potential of these medications to transform lives. With the right mindset and support, people can achieve their weight loss goals and improve their overall wellbeing. The statistics are also impressive, with some studies showing that up to 80% of participants achieve significant weight loss with Ozempic or Mounjaro. In conclusion, Ozempic and Mounjaro are two medications that have the potential to revolutionize the way we approach weight loss. They offer a new hope for those who have struggled with traditional methods, and the results are nothing short of amazing. With their impressive mechanisms, clinical studies, and success stories, it's clear that these medications are worth considering for those looking to achieve their weight loss goals. If you've had any experience with Ozempic or Mounjaro, please share your story in the comments below. And if you're interested in learning more about weight loss and health topics, be sure to check out my other videos for more information and tips. #appetitesuppressant, #tirzepatide, #GLP-1agonists, #weightloss, #obesitytreatment, #wegovy, #weightlossjourney,#ozempic, #ozempicsideeffects, #mounjaro, #fitness, #diet, #mounjaroweightloss, #insulinresistance, #obesity, #pharmaceuticalweightloss, #bodytransformation, #semaglutide #weightlossdrugs,#obesitytreatment,#healthtips, #glucagonlikepeptide, #ozempic #mounjaro #semaglutideforweightloss #weightlossdrugs

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How To Treat PCOS - PCOD Ka Ilaj- PCOS Diet For Weight Loss - Polycystic Ovarian Syndrome In Urdu PCOS (Poly Cystic Ovarian Syndrome) or PCOD is basically small cysts in the ovaries. Patients with PCOS have hormonal imbalances that result in irregular periods, infertility (banjhpan), and different hair and skin issues in the body. There is no treatment to cure PCOS/PCOD (Polycystic Ovarian Syndrome Ka Ilaj) discovered yet but it can be managed with some simple lifestyle changes. A woman with PCOS/PCOD can do simple changes in her lifestyle to manage PCOS easily like losing weight, eating healthy food, following a particular diet by a nutritionist, avoiding outside food especially junk food, and adopting physical activity. This will help to treat PCOS (PCOD ka ilaj) Any physical activity is important for the cure/treatment of PCOS (pcod ka Ilaj). It can be either walk or gym. Diet/Exercise doesn’t only help with PCOS but also keeps you healthy and active. It also keeps the hormones in balance which helps in the treatment of PCOS (Diet se pcod ka ilaj). Dr. Ayesha Abbas is one of the top Dietitians in Karachi. Dr. Ayesha is also available for Online Video Consultation at oladoc.com. To book an appointment with Dr. Ayesha, please visit the following link or call 042-3890-0939. https://oladoc.com/ayesha-abbas/?utm_source=youtube&utm_medium=referral&utm_campaign=Ayesha_abbas&utm_content=PCOS_and_weight_loss

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'Love Is Blind' alum Chelsea Blackwell shares her weight loss transformation after beginning the use of an injectable medication, despite facing criticism for doing so. Chelsea—who is now dating Tim Teeter following her breakup with ex-fiancé Jimmy Presnell—details the benefits of her recent lifestyle change, which includes working with a nutrition coach. Full Story: https://www.eonline.com/news/1415544/love-is-blinds-chelsea-blackwell-using-weight-loss-medication #enews #chelseablackwell #loveisblind About: The E! News team brings you the latest breaking entertainment, fashion and Pop Culture news. Featuring exclusive segments, celebrity highlights, trend reports and more, the E! News channel is the only destination Pop Culture fans need to stay in the know. Subscribe here: http://bit.ly/enewssub Connect: For More News - https://eonline.us/3MASskW E! News App - https://eonline.onelink.me/yMtl/4ead5017 Shopping - https://eonline.com/news/shop Facebook - https://www.facebook.com/enews/ Instagram - https://www.instagram.com/enews/ X - https://x.com/enews/ TikTok - https://tiktok.com/@enews

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30 minute fat burning low impact cardio indoor walking workout for beginners & women over 50! Indoor walk with dumbbell weights/optional walk 1.5 miles or 2.8 km burn 220 calories and walk 3500 steps in this fast paced indoor workout for all levels of fitness. This is a full body walking workout is part of the fabulous50s 14 day challenge and is suitable for beginners and can become your daily workout to increase your fitness level to burn fat and tone your whole body. Walk at home and #staysafe #stayhome. There is no excuse to not exercise any more. Enjoy xx Link for the new 14 day challenge... https://fabulous50s.com/new-14-day-challenge/ A 14 day workout program designed to help you get fit, lose weight and have fun!! 🎼 Music from Epidemic sound 🎼 AllI need is me - Elliot Adair - https://youtu.be/_dXQxPU2rVI Blood from a stone - Arch Tremors - https://youtu.be/RWgf9dYLqUs Ten Feet (Daxten Remix)- Curio - https://youtu.be/QIn1SxYYiYs Back in Memphis - The best off - https://youtu.be/mN6JwCeRAIs On a good day - My snake eyes - https://youtu.be/bORgMj6cKS0 So go get it - Elijah N - https://youtu.be/Yxka59ZrRhc All I need is me - Elliot Adair - https://youtu.be/_dXQxPU2rVI If you’re looking for trouble - https://youtu.be/ITJttUsAHU4 Strong enough to shine (instrumental version) - Conditional - https://youtu.be/0KX_6cOWntQ Welcome to fabulous50s! Here you will find content that relates to how to look younger, mature skincare, anti aging, wrinkles, how to dress over 50, style, fitness, health and beauty over 50. All the videos here have you, a mature Woman in mind and if you have any questions or video suggestions for mature Women, please feel free to leave your comment below. ***Disclaimer: Information provided in this video is of a general nature only and is for entertainment/educational purposes. We strongly recommend that you consult with your physician before beginning any exercise program. Performing any of these exercises is done so at your own risk.*** 🟪

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