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Novo Nordisk A/S’s shares fell by the most on record after a failed attempt to leapfrog rival Eli Lilly & Co. in the red-hot market for obesity drugs. Novo’s experimental obesity shot CagriSema helped patients lose an average of 20.4% of their weight over 68 weeks, short of the 25% weight loss that Novo had repeatedly predicted for its next-generation product. The study results were roughly in line with the performance of Eli Lilly’s Zepbound shot, which is already on the market and competes with existing Novo treatment Wegovy. Lilly is also working on a next-generation medicine, called retatrutide, which helped people lose up to about 24% of their weight in a mid-sized study last year. WATCH: Emily Field, Barclays’ head of European pharmaceutical research, says the selloff in Novo Nordisk’s shares is an overreaction. Novo’s shares plunged as much as 27% in Copenhagen, and are now down 15% for the year after a runup on the strength of Wegovy sales. Shares of Eli Lilly jumped 10% in premarket US trading. The share decline briefly knocked more than $120 billion from Novo’s market value. The results may suffice for approval for CagriSema, but they leave Novo with issues positioning the drug in the market, Simon Baker, an analyst for Redburn, said in a note. “They sought a superior result to Lilly and got one that is the same,” Baker said. Novo said it will start another trial in the first half of next year to help find out how best to boost patients’ doses. The company expects to seek regulatory approval for CagriSema toward the end of next year, a spokeswoman said in a statement. The study is one of the most anticipated this year in the field. Novo has been counting on CagriSema to help it ward off a growing roster of competitors, led by Eli Lilly, in a weight-loss market that’s predicted to grow to nearly $130 billion by 2030. For more on the results, Paul Sweeney and Norah Mulinda speak with Bloomberg Intelligence senior pharma analyst John Murphy. -------- Watch Bloomberg Radio LIVE on YouTube Weekdays 7am-6pm ET WATCH HERE: http://bit.ly/3vTiACF Follow us on X: https://twitter.com/BloombergRadio Subscribe to our Podcasts: Bloomberg Daybreak: http://bit.ly/3DWYoAN Bloomberg Surveillance: http://bit.ly/3OPtReI Bloomberg Intelligence: http://bit.ly/3YrBfOi Balance of Power: http://bit.ly/3OO8eLC Bloomberg Businessweek: http://bit.ly/3IPl60i Listen on Apple CarPlay and Android Auto with the Bloomberg Business app: Apple CarPlay: https://apple.co/486mghI Android Auto: https://bit.ly/49benZy Visit our YouTube channels: Bloomberg Podcasts: https://www.youtube.com/bloombergpodcasts Bloomberg Television: https://www.youtube.com/@markets Bloomberg Originals: https://www.youtube.com/bloomberg Quicktake: https://www.youtube.com/@BloombergQuicktake

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The ketogenic diet has gained immense popularity in recent years for its ability to help individuals lose weight, improve overall health, and boost energy levels. However, starting a keto lifestyle can be overwhelming, especially with all the conflicting information out there. That’s where “Kickin’ Keto: A Lively Approach to Ketogenic Living” comes in. This book offers a refreshing and lively take on the traditional keto diet, making it easier than ever to stick to your goals and enjoy the process.

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Unlike other keto resources that focus solely on what you can’t eat, “Kickin’ Keto” takes a different approach by highlighting all the delicious foods you can enjoy on the ketogenic diet. With mouthwatering recipes, creative meal ideas, and helpful tips and tricks, this book will inspire you to get creative in the kitchen and truly enjoy the process of living a keto lifestyle.

One of the biggest challenges of following a ketogenic diet is feeling restricted and deprived. With “Kickin’ Keto,” you’ll never have to worry about feeling like you’re missing out. The book offers a wide variety of recipes for every meal of the day, from breakfast to dessert, all designed to keep you satisfied and energized while staying in ketosis.

Another reason to choose “Kickin’ Keto” is its emphasis on balance and flexibility. While some keto plans can be overly strict and rigid, this book encourages you to listen to your body and make choices that work for you. Whether you’re new to the ketogenic diet or a seasoned pro, “Kickin’ Keto” offers a fresh perspective that will help you find success on your journey.

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When you embrace the Kickin’ Keto lifestyle, you’ll discover a whole new world of flavors and possibilities. Say goodbye to boring, bland meals and hello to delicious, nutritious dishes that will leave you feeling satisfied and content. Whether you’re a meat lover, a vegetarian, or somewhere in between, there’s something for everyone in the pages of this book.

With the help of “Kickin’ Keto,” you’ll learn how to make smart choices when it comes to eating out, social events, and cravings. Armed with practical tips and expert advice, you’ll feel confident navigating any situation while staying true to your keto goals. No more feeling like an outsider or having to explain your dietary choices – with “Kickin’ Keto,” you’ll fit right in and thrive.

One of the most exciting aspects of the Kickin’ Keto lifestyle is the community that comes with it. Join a supportive network of like-minded individuals who share your passion for delicious food and healthy living. Swap recipes, share success stories, and cheer each other on as you embark on this exciting journey together.

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Q: Is Kickin’ Keto suitable for beginners?

A: Absolutely! “Kickin’ Keto” is perfect for beginners who are looking to start their ketogenic journey on the right foot. With easy-to-follow recipes and practical advice, this book will guide you every step of the way.

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In an office in Bagsværd near Copenhagen, young biotechnologist Lotte Bjerre Knudsen has been made project manager for a promising, but uncertain project of converting the hormone GLP-1 into a drug that can prove effective in combating the rapidly growing wave of diseases such as type 2 diabetes in the 1990s. If she fails, the project will fold. Follow Episode 2 "If you don't fix this" of this advent calender from the Novo Nordisk Foundation "The Story of GLP-1". 00:00:00 - Introduction: Lotter Knudson's project on GLP-1 00:00:03 - The aim of converting GLP-1 into a drug 00:00:21 - The high stakes of the project 00:00:46 - Initial failed experiments with native GLP-1 00:01:14 - Innovative ideas for stabilizing GLP-1 00:01:50 - Use of fatty acids and albumin for protection 00:02:06 - Issues with purifying fatty acid-bound GLP-1 00:02:22 - A small crisis meeting and the biology-chemistry interplay 00:02:37 - Breakthroughs in understanding GLP-1’s biology 00:03:07 - The built-in safety switch of GLP-1 00:03:31 - Discoveries in Copenhagen on insulin and glucagon secretion 00:04:00 - Challenges in treating people with GLP-1 00:04:08 - Discovery of DPP-4 enzyme’s role 00:04:17 - Development of DPP-4 enzyme inhibitors 00:05:01 - Historical analogies with ACE inhibitors 00:05:47 - Development of DP4 inhibitors 00:06:18 - Long-acting GLP-1 analogs and their limitations 00:06:48 - Chemistry innovations to stabilize GLP-1 00:07:02 - John Eng’s discovery of Exendin-4 from Gila monster venom 00:08:02 - Challenges faced in patenting and developing Exendin-4 00:08:42 - Collaboration with Amylin Pharmaceuticals 00:09:53 - Management challenges and a deadline to fix the GLP-1 project 00:10:06 - Revisiting the initial solutions with new resources 00:10:48 - Issues in clinical trials and correct dosing 00:11:22 - Market competition and the first GLP-1 drug approval 00:12:00 - Investor skepticism and motivation to succeed

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