Transcript Overcome The Hurdles Of Weight LossWhile looking over the research on the effect of GLP-1 receptor agonists on alcohol consumption, I stumbled across a recent and _really_ interesting paper on how that class of drugs affects sensation. It's "Glp-1 Receptor Agonists Significantly Impair Taste Function" by Rafa Khan and Richard L. Doty in _Physiology & Behavior_ Vol. 291 (published version at https://www.sciencedirect.com/science/article/abs/pii/S003193842400341X and white paper version at https://papers.ssrn.com/sol3/papers.cfm?abstract_id=4953499 ). Don't necessarily take that title on its face, as the details are super important and incredibly interesting and maybe not as dire as you'd think. And, well, I felt like it would be a good use of my platform to discuss all of this. So that's what we're doing today, talking about this hugely consequential new class of drugs - Wegovy/Ozempic (semaglutide), Mounjaro (tirzepatide, although that's also a GIP), and whatever else is going to be out there - with an eye towards spirits nerdery. First I broadly discuss the history and basic mechanisms of these drugs, with a brief detour into side effects and what I would consider to be "best practices" in using them for weight loss purposes. (N.b., I don't get into treatment for type 2 diabetes and that's another set of concerns, also I am not a doctor and please consult a medical professional for all this etc..) And then I discuss the paper above. And... well, it's complicated. 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