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Calling all those with a passion for cardiovascular prevention! In this episode of the CardioNerds Cardiovascular Prevention Series, we take a deep dive into the world of glucagon-like peptide-1 (GLP-1) receptor agonists. Along the way, you’ll hear about the biology of the GLP-1 molecule and its related peptides, learn more about how GLP-1 agonists promote glycemic control, weight loss, and cardiometabolic health, and explore the current body of literature supporting the individualized application of these medications to patients with diabetes, obesity, and/or ASCVD. Join Dr. Christian Faaborg-Andersen (CardioNerds Academy Fellow and Internal Medicine Resident at MGH), Dr. Gurleen Kaur (Director of the CardioNerds Internship, Chief of House Einthoven, and Internal Medicine resident at BWH), and Dr. Rick Ferraro (CardioNerds Academy House Faculty and Cardiology Fellow at JHH) for a wide-ranging discussion on GLP-1 and GIP agonists with Dr. Dennis Bruemmer (Cardiologist and Director of the Center for Cardiometabolic Health in the section of Preventive Cardiology at the Cleveland Clinic). Show notes were drafted by Dr. Christian Faaborg-Andersen. Audio editing was performed by CardioNerds Academy Intern, student Dr. Tina Reddy. This episode was produced in collaboration with the American Society of Preventive Cardiology (ASPC) with independent medical education grant support from Novo Nordisk. See below for continuing medical education credit. Claim CME for this episode HERE. CardioNerds Prevention PageCardioNerds Episode PageCardioNerds AcademyCardionerds Healy Honor Roll CardioNerds Journal ClubSubscribe to The Heartbeat Newsletter!Check out CardioNerds SWAG!Become a CardioNerds Patron! Pearls and Quotes - GLP-1 Agonists: Mechanisms to Applications The selection and dosing of GLP-1 and GIP agonists (GLP-1s and GIPs) depends on their intended use as an anti-glycemic or anti-obesity agent. The cardiovascular benefits of GLP-1s and GIPs may be independent of improvements in glycemic control, and in part be driven by reduction in inflammation, a key driver of arterial plaque formation. In patients with comorbid coronary artery disease, obesity, and diabetes, GLP-1 agonists and SGLT-2 inhibitors should be used as first-line agents, over metformin. Tirzepatide is a dual agonist that activates GIP and GLP-1 receptors. GIP is highly expressed in the brain, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Caution should be used with GLP-1 agonists in patients with long-standing diabetes complicated by gastroparesis, as well as incompletely treated diabetic retinopathy. GI upset is not uncommon with GLP-1/GIP agonists, and switching to a different agonist is unlikely to help.  Show notes - GLP-1 Agonists: Mechanisms to Applications What are the mechanisms of action by which GLP-1 and GIP controls blood sugar and body weight? Glucagon-like peptide-1 (GLP-1) is an endogenous hormone that is secreted in response to an oral glucose load. It promotes insulin release, inhibits glucagon secretion, and slows gastric emptying via the brain-intestine axis, leading to satiety. GLP-1 agonists are medications that mimic the effect of this hormone and, on average, lower hemoglobin A1C by 0.8% to 1.5%. These medications include semaglutide, liraglutide, and dulaglutide. Glucose-dependent insulinotropic polypeptide (GIP) is also an endogenous hormone, similarly secreted by the body in response to an oral glucose load such as a meal. GIP is highly expressed in the arcuate nucleus and hypothalamus, which may mediate satiety, promote energy expenditure, and enhance peripheral glucose metabolism. Tirzepatide is a dual GLP-1/GIP agonist. What is the role of GLP-1/GIP agonists in patients with overweight/obesity and/or type 2 diabetes? How does the dosing of GLP-1/GIP medications change with their intended disease target?

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✅OFFICIAL WEBSITE: https://shorturl.at/WdH1o ✅OFFICIAL WEBSITE: https://shorturl.at/WdH1o ✅What is Ikaria Lean Belly Juice? Ikaria Lean Belly Juice is a dietary supplement designed to support weight loss. It works by enhancing metabolism and managing fat storage in the body. The formula includes eight primary ingredients targeted at weight loss, along with seven additional components to improve flavor and texture. Designed for both men and women aged 18 and above, Ikaria Lean Belly Juice is available in powder form. Each jar of the supplement contains a month's supply, ensuring convenience and ease of use. Manufactured in a secure facility under stringent supervision and precise calculations, this supplement prioritizes safety and efficacy. ✅Powerful Ingredients of Ikaria Juice Lean Belly Juice Ikaria is a health supplement designed to promote weight loss safely, thanks to its effective and natural ingredients. Here are some of the key components: - **Milk Thistle**: This plant, part of the daisy family, contains antioxidants that improve liver health and promote weight loss. It helps boost metabolism, reduces inflammation, and balances your diet, aiding in safe calorie burning. - **Citrus Pectin**: It aids in weight loss by controlling appetite and enhancing digestion. A higher metabolism from this ingredient helps burn excess calories and discourages unhealthy food consumption, supporting overall health. - **Panax Ginseng**: Known for balancing blood sugar levels, it prevents excessive insulin production and promotes a balanced diet. This, in turn, supports healthy weight loss by safely burning excess calories. - **Taraxacum**: This ingredient supports weight loss by improving digestion and metabolism. It helps reduce water bloating and eliminates excess fluids from the body. - **Bioperine**: Extracted from black pepper, Bioperine helps in weight loss by promoting the consumption of healthy food and aiding in the healthy burning of calories, contributing to increased activity levels. - **Hibiscus**: Found in Africa, Asia, and other regions, hibiscus promotes healthy weight loss, improves digestion, reduces inflammation, and addresses other obesity-related health issues. - **African Mango Extract**: This extract supports weight loss while enhancing immunity and energy levels, making you feel healthier and more active. These are just some of the ingredients in Lean Belly Juice Ikaria. For a complete list, refer to the product label. ikaria lean belly juice,ikaria lean belly juice review,ikaria lean belly juice supplement,ikaria lean belly juice weight loss,ikaria lean belly juice ingredients,ikaria juice,ikaria lean belly juice reviews,ikaria lean belly juice customer review,ikaria lean belly juice where to buy,lean belly juice,lean belly juice review,lean belly juice reviews,lean belly juice ingredients,lean belly juice supplement,ikaria juice reviews,lean belly juice side effects

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Watch the explosive love is blind reunion when the "nice guys" get exposed!: "(1247) When The Nice Guys Get Exposed | Love is Blind Reunion Season 6 " https://www.youtube.com/watch?v=t87K2K7DqVI --~-- #Lizzo Today we're talking about Lizzo and the recent fight on twitter where she said the rude comments she gets makes her want to quit! Check out the new merch! https://michellemcdaniel.junipercreates.com Grab a donut! https://prodoughbakery.com/ Workout Programs https://michellemcdaniel.net/products/weight-loss-support-group Instagram https://www.instagram.com/michelle_mcdaniel/?hl=en TikTok https://www.tiktok.com/@michellemcdaniel3 Editor: Liora Naor

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Natural Ozempic: Can Foods REALLY Mimic Weight Loss Drugs? | The Science REVEALED! ✅Ozempic: A pharmaceutical GLP-1 receptor agonist, is designed to regulate blood sugar and suppress appetite for extended periods. While certain foods—such as fiber-rich grains, legumes, and proteins—can stimulate the body's natural GLP-1 production, their effects are short-lived and far less potent than the drug. Unlike Ozempic, which provides sustained hormonal regulation, these foods only offer a temporary satiety boost. Scientifically, no natural ingredient can replicate the precise, long-lasting impact of Ozempic, making the idea of a "natural Ozempic" misleading. What You’ll Learn in This Video: ✅ The science behind Ozempic and GLP-1 receptor activation ✅ Can foods truly mimic the effects of weight loss drugs? ✅ Which foods boost GLP-1 production naturally? ✅ The limitations of "natural Ozempic" claims ✅ Research-backed insights on weight loss and satiety ⌛OUTLINE: 00:00:00 Intro! 00:00:19 What is Ozempic? 00:00:50 Research Insight 00:01:03 The ‘Natural Ozempic’ Hype 00:01:33 Can Foods Boost GLP-1 Naturally? 00:02:40 The Limitations of Natural GLP-1 Boosting 00:03:12 The Takeaway – What Really Works? 00:03:42 Conclusion!!! Many influencers claim that certain foods act as "natural Ozempic," but is this really true? Today, we break down the scientific facts behind weight loss drugs like Ozempic and explore whether foods like chia seeds, avocado, and fiber-rich diets can genuinely replace pharmaceutical interventions. 🔬 Research References: 1. GLP-1 & Satiety Research – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1234567/ 2. Ozempic & Weight Loss Studies – https://www.nejm.org/doi/full/10.1056/NEJMoa2032183 3. Fiber & Gut Hormones Impact – https://gut.bmj.com/content/68/11/2103 👉 Don’t forget to LIKE, COMMENT, and SUBSCRIBE for more deep-dive fitness & nutrition breakdowns! 🔥 ⏩Don't Miss Out On This Amazing Topics that actually Might Help You Stay Healthy!!! 1️⃣ Top 5 Trending Superfoods in 2025 – Backed by Science! : https://youtu.be/VHYitemmkWM?si=qeOnhclPzkTY21P_ 2️⃣ Ancient Ayurveda vs. Modern Fitness – The TRUTH You Need to Know! : https://youtu.be/EE8KpskWfHs?si=qbZ8qUawLaH9n1Pb 3️⃣ Moringa: The Superfood That Fitness Experts Don’t Want You to Miss! : https://youtu.be/v0Bg25cmncc?si=yL5VGdn8q-kDdOFt #Ozempic #NaturalWeightLoss #GLP1 #FatLoss #WeightLossScience #IntermittentFasting #HealthMyths #ScienceBasedFitness

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There is a secret to burning fat and it has nothing to do with how many calories you consume or how many miles you run or how long you fast. Food and exercise definitely are important, but they mean nothing if this one thing isn't in place. Your insulin levels. It can make or break your goals. Get a Keto Mojo to help you keep track of your insulin levels via your ketone-producing (aka fat burning) capability. link to Keto-Mojo: https://amzn.to/3TLGvwj

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