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00:00 Intro 01:12 Eli Lillys resultat för läkemedelskandidaten orforglipron, en potentiellt oral behandling mot fetma 10:01 Initativ från USA för att sänka läkemedelspriser samt USA-investeringar från Roche och Abbvie 10:57 Sedana Medicals snabbspår i USA för sin inhalationssedering 11:32 Danske Bank inleder bevakning av Vicore Pharma med en köprekommendation 12:09 Kontantbudet på 145 kronor per aktie på Biotage 13:00 Getinges rapport för 1 kv och riktkursförändringar 14:42 Xvivos rapport för 1 kv samt höjd rekommendation från Danske Bank 15:53 EU-godkännandet för alzheimersläkemedlet Leqembi Trading Direkt Healthcare tar upp studieresultat från Eli Lilly för orforglipron. Läkemedelskandidaten har bland investerare framför allt rönt intresse som en potentiell oral behandling mot fetma. Bland rapporter från veckan som gått sätter vi ljuset på medicinteknikbolagen Getinge och Xvivo Perfusion. Det senare av de två bolagen har även fått en uppgraderad rekommendation från Danske Bank till behåll från sälj. Danske Bank har även inlett bevakning av forskningsbolaget Vicore Pharma med en köprekommendation. Linc-ägda Sedan Medical har fått ett snabbspår till USA-marknaden för bolagets inhalationssedering. Riskkapitalbolaget KKR har lagt ett kontantbud på Biotage om 145 kronor per aktie. Läkemedelsbolaget Bioarctic fick till slut ett EU-godkännande för alzheimersläkemedlet Leqembi. Trading Direkt Healthcare sänds varje måndag klockan 12.00 med fokus på de senaste händelserna inom life science.

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In this episode of the Pharm So Hard Ambulatory Care Podcast, the hosts discuss various studies and trials related to GLP-1 medications for weight management and cardiovascular outcomes. They provide updates on their personal lives and share their experiences with different vehicles, such as Jeeps and Broncos. The studies discussed include the Surmount 1 study, which showed significant weight loss in patients without diabetes; the Risk of Gastrointestinal Adverse Events Associated with GLP-1s study, which highlighted potential side effects of GLP-1 medications; the SELECT trial, which demonstrated the effectiveness of semaglutide in reducing cardiovascular events in patients with obesity and pre-existing cardiovascular disease; and a phase 2 trial of Retro-True Tide, a triple hormone receptor agonist that showed impressive weight loss results. The hosts also discuss the limitations and implications of these studies. Takeaways • GLP-1 medications have shown significant weight loss in patients without diabetes. • GLP-1 medications may have gastrointestinal side effects, but the overall risk is small compared to the potential benefits. • Semaglutide has been shown to reduce cardiovascular events in patients with obesity and pre-existing cardiovascular disease. • Retro-True Tide, a triple hormone receptor agonist, has shown impressive weight loss results in a phase 2 trial. • It is important to consider the limitations and implications of these studies when evaluating the use of GLP-1 medications.