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Keto Life has been revolutionizing the health and wellness industry, offering a new approach to weight loss and overall well-being. The ketogenic diet has gained popularity in recent years due to its ability to help individuals achieve their weight loss goals and improve their health in various ways. The success of Keto Life has caught the attention of many, including the investors on the hit television show Shark Tank.

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When the founders of Keto Life appeared on Shark Tank, they were seeking an investment to help take their business to the next level. The Sharks were impressed by the product and the positive results that customers were experiencing. They saw the potential for Keto Life to transform lives and make a significant impact in the health and wellness market.

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In this episode we dive into the benefits, risks and realities of modern weight loss drugs. Drugs like Ozempic, Wegovy and Mounjaro have hit the world by storm, and as they become more accessible, will only continue to do so. There’s a lot of stigma and misunderstanding about them, and their side effects, so we wanted to share a balanced approach to how they could be integrated into a fitness journey. On a mass general population level, they’ll be a game changer in reducing obesity - you can get all the benefits of diet and exercise without doing much. If you’re watching to this however, you want a more holistic approach to your transformation, so we share insights into who it may be useful for, why and how it could be utilised, or not. Remember, a lifestyle-first approach focusing on long-term habit building and identity integration is always going to be key if you want to be a high performer in every area of life. Chapters: 00:00 Introduction to Weight Loss Drugs 02:51 Understanding How Weight Loss Drugs Work 05:57 Research and Effectiveness of Weight Loss Drugs 09:05 Pros and Cons of Weight Loss Drugs 12:00 Social Stigma and Ethical Considerations 15:01 Long-term Use and Dependency on Weight Loss Drugs 17:58 Accessibility and Future of Weight Loss Drugs 20:59 Integrating Weight Loss Drugs into Transformation Journeys 22:59 Navigating the Complexities of Weight Loss Drugs 26:03 The Role of Lifestyle Changes in Weight Management 30:21 Understanding the Psychological Impact of Weight Loss 39:21 The Interplay of Genetics and Environment in Weight Management Next steps: 1) Apply for 1-1 coaching: https://www.rntfitness.co.uk/pro 2) Take our quiz to see if you’re ready for a transformation: http://www.rntfitness.co.uk/transform 3) Get our free book shipped to your door: https://bit.ly/tybtylform 4) Try our free 28 day fat loss accelerator: https://www.rntfitness.co.uk/transformation-accelerator Follow RNT Fitness: Website - http://www.rntfitness.com LinkedIn - https://uk.linkedin.com/company/rnt-fitness Facebook - http://www.facebook.com/rntfitness Instagram - http://www.instagram.com/rnt_fitness TikTok - https://www.tiktok.com/@rntfitness Follow Akash: Facebook - http://www.facebook.com/akashvaghela LinkedIn - https://uk.linkedin.com/in/akash-vaghela Instagram - http://www.instagram.com/akashvaghela TikTok - https://www.tiktok.com/@_akashvaghela

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A 61-year-old man with diabetes, heart failure (EF 25–30%), obesity, and CKD—how do you decide the next step in therapy? In this powerful episode of Case by Case, three expert clinicians dissect a post-hospitalization case involving a patient with multiple overlapping chronic conditions: Type 2 diabetes, HFrEF, obesity, and impaired renal function. The team weighs the benefits and limitations of SGLT2 inhibitors vs. GLP-1 receptor agonists—and the nuances of when to use both. 🎙️ Topics covered include: • Dapagliflozin in heart failure with reduced EF • Semaglutide and emerging data from the FLOW trial • GLP-1 risks in HFrEF: What the evidence (and gaps) suggest • Clinical nuance: when A1C is good but the patient still needs help • How to argue your case with payers using evidence-based trials 🎓 Meet the Experts: • Dr. Marie E. McDonnell (Harvard / Brigham), Endocrinologist and outcomes researcher focused on complex diabetes care. • Dr. Jan N. Basile (MUSC), Clinical hypertension and primary care expert with decades of CME leadership. • Dr. Nihar R. Desai (Yale), Cardiologist and health systems leader pioneering value-driven care. 💬 “It’s not about A1C—it’s about total disease control: renal preservation, CV death, and survival.” 🔗 Register to claim CME for this panel discussion plus more: https://www.cmemeeting.org/online-cme-courses/10th-diabetes-spring-conference 👍 Like, comment, and subscribe for more expert-level clinical cases each episode.

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These drugs--Tirzepatide and Semaglutide--are not just changing the weight loss game. Every day new information is published regarding their efficacy in a wide range of chronic illnesses. They give us an exciting new tool for the management of complex illness. - The topic is GLP-1 receptor agonists (GLP-1 RAs), such as Ozempic, Wegovy, and Mounjaro (semaglutide and tirzepatide). - These drugs, originally developed for diabetes and weight loss, are being explored for broader benefits in patients with complex chronic illnesses, including long COVID and mast cell activation syndrome (MCAS). ### **Clinical Observations** - The hosts recount remarkable improvements in patients with severe, treatment-resistant symptoms (e.g., long COVID, MCAS) after starting very low doses of GLP-1 RAs. - Examples include: - A physician with disabling long COVID who, after starting a low dose of tirzepatide, regained mobility and improved overall function. - A woman with post-COVID and post-vaccine reaction, severe edema, food intolerance, and autoimmune markers, who experienced a dramatic reduction in swelling and improved food tolerance after just three injections. ### **Mechanisms & Theoretical Discussion** - GLP-1 is a natural hormone involved in insulin secretion and glucose metabolism; synthetic versions are longer-acting. - GLP-1 receptors are found throughout the body: central nervous system, muscles, immune cells (including mast cells), joints, and more. - The hosts hypothesize that the drugs’ benefits in complex illness may stem from: - Mast cell stabilization (reducing multi-system inflammation). - Modulation of immune function. - Effects on the central nervous system, possibly crossing the blood-brain barrier. - Notably, benefits are observed at microdoses (one-tenth or less of standard diabetes/weight loss doses), with minimal side effects. ### **Clinical Pearls & Practical Considerations** - Patients who are not overweight also benefit, and weight loss is minimal at these low doses. - Appetite suppression and improved food tolerance are common, leading to better quality of life. - The hosts encourage patients to re-challenge foods they previously could not tolerate after starting treatment. - There is curiosity about whether increasing the dose would yield further benefits or more side effects. - The drugs also seem to help with neurological symptoms, joint pain, and possibly even visual disturbances associated with long COVID. ### **Barriers and Logistics** - Insurance typically does not cover these drugs for off-label use, so patients rely on compounding pharmacies. - Recent FDA actions threaten the availability of compounded versions, as compounding is only allowed during official shortages. - Dosing compounded versions can be confusing, as patients must measure their own doses with insulin syringes, unlike the user-friendly commercial pens. ### **Mechanistic and Evolutionary Speculation** - The hosts discuss why GLP-1 receptors are so widespread, theorizing that modern diets and processed foods have disrupted normal physiology, and these drugs may help restore balance. - They propose that GLP-1 RAs could become important in anti-aging/longevity medicine due to their anti-inflammatory effects, similar to drugs like metformin and rapamycin. ### **Research & Future Directions** - The hosts call for more systematic data collection, including biomarkers of inflammation, to better understand and track the drugs’ effects. - They note the lack of robust clinical trial data for these off-label uses and suggest the need for case series and further research. - There is interest in comparing different GLP-1 RAs (semaglutide vs. tirzepatide) and their relative efficacy for inflammation vs. weight loss. ### **Conclusion** - The hosts are enthusiastic about the potential of GLP-1 RAs in treating complex chronic illnesses, especially given the rapid and profound improvements seen in some patients. - They plan to revisit the topic as more experience and data accumulate, and to explore combination therapy with other anti-inflammatory/anti-aging drugs like rapamycin. ## **Key Takeaways** - **GLP-1 receptor agonists, at very low doses, appear to provide significant, rapid benefits for some patients with chronic, complex illnesses (e.g., long COVID, MCAS), beyond their approved uses.** - **Benefits include reduced inflammation, improved mobility, better food tolerance, and improved neurological symptoms.** - **Mechanisms may involve mast cell stabilization, immune modulation, and central nervous system effects.** - **Access is limited by insurance and regulatory issues; compounded versions are threatened by FDA policy changes.** - **There is a need for more systematic research, including biomarker tracking and case series, to validate these observations.** - **GLP-1 RAs may have a future role in longevity and anti-aging medicine due to their anti-inflammatory properties.**

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Some people report hair loss while taking GLP-1 medications like Mounjaro or Wegovy. But is it really caused by the medication? In this video, our doctor explains the possible causes, what the research says, and what you can do if you're noticing hair thinning. Timestamps: 0:00 - Intro 1:34 - What is the prevalence of hair loss with GLP-1 receptor agonists? 4:55 - What is the mechanism? 7:02 - Hormonal changes and hair loss 8:43 - What is a normal hair growth cycle? 11:51 - What are the treatment options for hair loss? ---------------- ABOUT SIMPLYWEIGHT Healing with Compassion, Driven by Science Simplyweight transforms lives by combining decades of clinical expertise with personal insight to create holistic digital and clinical offerings. We help people understand and nurture themselves at a deep level, unlocking a wellspring of physical, emotional and mental health that goes far beyond a number on a scale. ---------------- BOOK AN APPOINTMENT AT OUR CLINICS: VIRTUAL OR IN-PERSON Simplyweight operates specialist clinics offering bespoke, medical weight loss services. We help people not only lose weight and maintain it but also treat weight-related conditions such as type 2 diabetes, thyroid issues, PCOS/PCOD, infertility, fatty liver, sexual dysfunction, and more. Virtual and in-person consultations are available for your convenience. VISIT OUR UK CLINIC: www.thelondonobesityclinic.com VISIT OUR INDIA CLINIC: www.thelondonobesityclinic.co.in ---------------- ABOUT DR. RAJ 🩺 Hi, I’m Dr. C. Rajeswaran (Dr. Raj), a Consultant Endocrinologist and Bariatric Physician with over 25 years of experience helping thousands of people manage obesity and related health conditions globally. On this channel, my team and I provide science-based advice to help you understand your body, hunger, and metabolism, guiding you to a healthier weight and better quality of life. We’re here to cut through the misinformation and support your well-being. Visit my website for more: https://www.docrajeswaran.com/ Declaration: It is always a good practice to declare any conflict of interest. Dr C. Rajeswaran is a director of Simplyweight. Dr Rajeswaran has been a speaker and/or attended advisory board meetings for the following pharmaceutical companies: Boehringer Ingelheim Ltd, Sanofi, MSD, Novo Nordisk, Knapp, Janssen, Sunovion, Pfizer, Astra Zeneca and Eli Lilly. ---------------- DISCLAIMER: This video is not intended to provide diagnosis, treatment, or medical advice. Content on Simplyweight's YouTube channels or other social media channels, including any social media channels associated with our brand or our clinics, is meant for informational purposes only and is not a substitute for seeking medical advice or treatment from a prescribed healthcare professional. We always recommend that you consult with your physician or relevant healthcare professional before starting any new weight loss plan, activity, altering the dose of any medication or starting a new medication. Readers/viewers who take any advice given or gleaned in isolation that is without prior consultation with their health care provider do so at their own risk. 🤖 AI DISCLOSURE: We believe in combining medical expertise with innovative technology to share knowledge about weight management and healthy living. This video may include AI-enhanced elements (such as translations, dubbing, avatars, voiceovers, images, and other creative elements) to help us deliver clear, accessible health knowledge that reaches as many people as possible. While our healthcare team oversees our content, this video is for informational purposes only and should not be considered medical advice. For personalised weight loss support, you can book a consultation (virtual or in-person) at one of our Simplyweight clinics. ---------------- #HairLoss #HairHealth #MounjaroWeightLoss #WegovyWeightLoss #Wegovy #Mounjaro #GLP1 #WeightLossMedications #Ozempic #Tirzepatide #Zepbound #Semaglutide #WeightLossInjections #MounjaroInjection #WeightLoss

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🔍 Berberine has gone viral as a "natural GLP-1 alternative" - but what does the science actually say? In this video, we break down the research, benefits, and potential risks of this trending supplement. Berberine, traditionally used in Chinese medicine, has shown promising results for: ⏱️ 0:15 - Weight loss potential ⏱️ 0:30 - Blood pressure benefits ⏱️ 0:45 - Glucose control improvements ⏱️ 1:00 - Cholesterol management ⏱️ 1:15 - Important drug interactions to know ⚠️ IMPORTANT: Berberine may interact with medications including oral contraceptives and antidepressants. Always consult with your healthcare provider before starting any supplement. 🔬 While early research on Berberine shows promise, it hasn't undergone the same extensive clinical trials as GLP-1 medications. Make informed decisions about your health! 🔔 Download SuppCo for evidence-based supplement information: www.supp.co #Berberine #WeightLossSupplements #GLP1Alternative #SupplementScience #SuppCo #WeightManagement #NaturalSupplements #MetabolicHealth

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Dr. Daniel Drucker of the University of Toronto is sharing a US$3 million Breakthrough Prize in Life Sciences prize with four international colleagues for discovering and developing the GLP-1 hormone used in now-famous diabetes and weight loss drugs Ozempic, Wegovy and Mounjaro. They received the award at a ceremony in Los Angeles on April 5, 2025. (April 7, 2025) Subscribe and enable notifications for more videos from The Canadian Press — For the latest and most important news of the day | www.canadianpressnews.ca Listen to CP Newswatch, a daily podcast covering the most important news and sports stories| https://www.youtube.com/@CdnPress/podcasts The Canadian Press on X (formerly Twitter) | https://twitter.com/CdnPressNews The Canadian Press on LinkedIn | https://www.linkedin.com/showcase/98791543/ — With more than 180 journalists, The Canadian Press provides up-to-the-minute newsfeeds of articles, graphics, photos, audio and video clips that help keep your audience coming back for more.

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Dry Fasting Science - How You Lose Fat While Dry Fasting? In This Video I discuss the science behind dry fasting and how it is effective for losing weight and........ I go over the metabolism of fat cells and carbohydrates that happen in the body while dry fasting and....... I also discuss about Ramadan and the research that is being used to see the benefits of dry fasting such as decrease in insulin levels better metabolism and........ You can find me on Instagram at https://www.instagram.com/doctorlegrand/ Like Our Facebook page https://www.facebook.com/doctorlegrand/ Follow us on twitter: https://twitter.com/doctorlegrand Here is more information about our clinic: http://www.natureshealthnd.com/ References: Percentage of water in fat: https://www.nap.edu/read/10925/chapter/6#76 Metabolic water production: http://www.oxfordreference.com/view/10.1093/oi/authority.20110803100152720 Women during Ramadan research study: https://academic.oup.com/ajcn/article-abstract/62/2/302/4651343 Combustion of fat and carbs into metabolic water: https://www.nature.com/articles/150021a0 CAVEAT: This content is strictly the opinion of Dr. LeGrand and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Dr. LeGrand nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program. Music by: bensound.com

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Ever wondered if a diabetes med could help you lose weight? Meet Metformin, the unexpected weight-loss “buddy” that’s more side dish than main course. Let’s dive in! https://tinyurl.com/bloodsugar102 #ozempic #type2diabetes #diabetesmanagement #bloodsugar

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