Transcript Semaglutide Indianapolis Indy Weight Loss ClinicsMounjaro Weight loss Before and After | How it works, Side Effects, How To Inject #mounjaro Around 30 years ago, scientists found a special compound in the saliva of the Gila monster that acted like GLP-1, which is a natural hormone released by our gut that regulate blood sugar levels, stimulate insulin release, and even promote weight loss. This compound was named exendin-4 or exenatide. Since the introduction of exenatide, scientists have developed other synthetic GLP-1 receptor agonists, expanding the treatment options for type 2 diabetes and weight management. Which brings us to today’s video about the newest diabetes and weightloss drug, Mounjaro. So What is mounjaro ? Mounjaro is the brand name for Tirzepatide. Now tirzepatide unlike the predecessor exenatide, has a dual action, it mimics the effect of both, glucose-dependent insulinotropic polypeptide (GIP) AND glucagon-like peptide-1 (GLP-1) Both GIP and GLP-1 are naturally occurring hormones that play important roles in regulating blood sugar levels and body metabolism. They’re incretin hormones released by your gut after a meal with the primary aim of causing insulin secretion and reducing appetite. How does Mounjaro work for weightloss? GLP-1 effects GIP effects Acts on the brain to reduce appetite & increase satiety and fullness Acts on gut to slow stomach emptying which also leads to feeling full Acts on adipose tissue to break down fat Enhances all the GLP-1 effects Reduced nausea and vomiting What is compounded mounjaro? While mounjaro is exclusively made by Eli lilly and company. Compounded Mounjaro or tirzepatide is tailor-made made for you by your pharmacist from raw ingredients based on your doctor’s prescription. And may cost less. However, compounded Mounjaro (tirzepatide) is not subject to FDA approval and may not have the same safety, quality and efficacy as FDA-approved drugs, and may cause dangerous side effects. So What’s the difference between mounjaro and ozempic or wegovy? So wegovy and ozempic contain semaglutide while mounjaro contains tirzpatide and the reason semaglutide and tirzepatide sound similar is because they belong to the same drug group, that is GLP1 agonist. However, Tirzepatide or mounjaro has additional GIP effects, which leads to: Greater weight loss effects and less nausea & vomiting as compared to wegovy or ozempic. How to inject Mounjaro? Mounjaro is administered as a subcutaneous or “under the skin” injection, typically once a week in a dose that’s determined by your healthcare provider. Choose an injection site like your stomach, thighs, or the back of your upper arms. Pull off the gray base cap. Place the clear base flat against your skin at the injection site. Unlock by turning the lock ring. Press and hold the button for up to 10 seconds. Listen for the first click. It means the injection has started. The second click means that the injection is complete. Avoid injecting at the same site again. Make sure to ask your doctor to teach you the process. what are the side effects of mounjaro? Nausea, vomiting, diarrhea or constipation and stomach pain are the common side effects. These effects decrease over time. Mounjaro can also cause low blood sugar, inflammation of pancreas and kidney failure. Mounjaro might interact with your birth control pills so be sure to consult your doctor about it. Additionally people with a family history of thyroid cancer or MEN syndrome are recommended to not take the drug. How to minimize side effects? Drink lots of water and stay hydrated. Eat small meals and stop eating when u feel full. Thank you for watching. 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When Semaglutide is administered, it stimulates insulin secretion, reduces glucagon production, and slows down gastric emptying, leading to a feeling of fullness and reduced food intake. Furthermore, Semaglutide has been shown to increase the sensitivity of cells to insulin, allowing for better utilization of glucose and an overall improvement in blood sugar control. This multifaceted approach not only aids in weight loss but also helps manage conditions such as type 2 diabetes, making Semaglutide a valuable asset in the fight against obesity. It is important to note that Semaglutide is typically prescribed in conjunction with diet and exercise for optimal results. The drug is available in injectable form, with varying dosages depending on the individual’s needs and response to treatment. Regular monitoring by healthcare providers is essential to ensure the safe and effective use of Semaglutide. Potential Side Effects of Semaglutide Like any medication, Semaglutide may cause side effects in some individuals. Common side effects include nausea, vomiting, diarrhea, and abdominal discomfort, especially when starting treatment or increasing the dosage. These symptoms tend to subside over time as the body adjusts to the medication. In rare cases, Semaglutide may cause more serious side effects such as pancreatitis, kidney problems, or allergic reactions. It is important to seek medical attention if any unusual symptoms occur while taking Semaglutide. Healthcare providers can assess the risks and benefits of continued treatment and make adjustments as needed to ensure patient safety. Patients with a history of pancreatitis, thyroid problems, or kidney disease should exercise caution when considering Semaglutide as a weight loss option. Health conditions and medication interactions can influence the suitability of Semaglutide for individual patients, highlighting the importance of thorough medical evaluation before initiating treatment. Success Stories with Semaglutide Despite potential side effects, many individuals have experienced significant weight loss and improved health outcomes with the help of Semaglutide. Clinical trials have demonstrated the drug’s effectiveness in promoting sustainable weight loss, with some participants achieving a reduction of up to 15% of their initial body weight. Success stories abound among patients who have struggled with obesity and related health issues for years, only to find relief and renewed vitality through Semaglutide treatment. The drug’s ability to address underlying metabolic imbalances and support long-term weight management has transformed the lives of many individuals, instilling hope and motivation for a healthier future. It is essential to approach weight loss with realistic expectations and a comprehensive strategy that includes dietary modifications, physical activity, and ongoing medical support. Semaglutide can be a valuable tool in this journey, but it is not a standalone solution. By combining the benefits of Semaglutide with lifestyle changes, individuals can achieve lasting weight loss and improved overall well-being. 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So do these drugs deliver on the promise of easy weight loss? And are they right for everyone? This episode, we talk with Mayo Clinic dietitian Tara Schmidt about the drugs that have taken weight loss culture by storm. From Mayo Clinic to your inbox, sign-up for free: https://mayocl.in/3e71zfi Visit Mayo Clinic: https://mayocl.in/2COVmlm Like Mayo Clinic on Facebook: https://www.facebook.com/mayoclinic/ Follow Mayo Clinic on Instagram: https://www.instagram.com/mayoclinic/ Follow Mayo Clinic on X, formerly Twitter: https://x.com/MayoClinic Follow Mayo Clinic on Threads: https://www.threads.net/@mayoclinic