Transcript Weight Lose Exercise At Homeworkoutfatlossloosebodyweightweightlossfitnessyogashortsvideo#diabetes #weightloss #antihungermedicine Weight loss by diabetes drug linked to "anti-hunger" molecule, finds study Researchers from Stanford Medicine and Harvard Medical School have discovered an “anti-hunger” molecule that is produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication metformin. The finding published in the journal Nature Metabolism revealed the critical role the molecule, called lac-phe, plays in metabolism, exercise and appetite which may help to discover a new class of weight loss drugs. Many people with diabetes who are prescribed metformin lose around 2% to 3% of their body weight within the first year of starting the drug. Although this amount of weight loss is modest when compared with the 15% or more often seen by people taking semaglutide drugs, the discoveries that led to those drugs also grew from observations of relatively minor, but reproducible, weight loss in people taking first-generation versions of the medications. “Until now, the way metformin, which is prescribed to control blood sugar levels, also brings about weight loss has been unclear,” said Jonathan Long, PhD, an assistant professor of pathology. “Now we know that it is acting through the same pathway as vigorous exercise to reduce hunger. Understanding how these pathways are controlled may lead to viable strategies to lower body mass and improve health in millions of people.” The researchers observed obese laboratory mice who were given metformin and found increased levels of lac-phe in their blood. They ate less than their peers and lost about 2 grams of body weight during the nine-day experiment. In the study, Long and colleagues analyzed blood plasma samples from people with Type 2 diabetes before and 12 weeks after starting metformin treatment. They found significant increases in lac-phe levels post-metformin. Additionally, among 79 participants in a multi-ethnic atherosclerosis study taking metformin, those on the drug had higher circulating lac-phe levels compared to non-users. Moreover, a statistical analysis of individuals in the atherosclerosis study who experienced weight loss over the study and follow-up period revealed a significant connection between metformin usage, lac-phe production, and weight reduction. “It was nice to confirm our hunch experimentally. The magnitude of effect of metformin on lac-phe production in mice was as great as or greater than what we previously observed with exercise. If you give a mouse metformin at levels comparable to what we prescribe for humans, their lac-phe levels go through the roof and stay high for many hours.” said Long. “These findings suggest there may be a way to optimize oral medications to affect these hunger and energy balance pathways to control body weight, cholesterol and blood pressure. 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Comment below — let’s inspire each other!Broccoli Recipe For Weight Loss 2022 Julia Morris Weight Loss ShortsDiscover the best GLP-1 tips for maximum weight loss with Dr. G as he explains how to avoid common pitfalls like plateaus and certain foods while using Ozempic, Mounjaro, and other weight loss injections like semaglutide and tirzepatide. Learn the expert advice on maximizing your results with these GLP-1 treatments, straight from a trusted MD. Whether you're new to weight loss injections or looking to enhance your progress, this video covers everything you need for long-term success. 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Always seek the advice of your physician or other qualified and trusted health provider with any questions you may have regarding any medical condition. Never disregard professional medical advice or delay in seeking it because of something you have seen or read on this channel. Reliance on any information provided by this channel is solely at your own risk.What Happens If You Drink Lemon Water For 14 Days Shorts Weightloss BellyfatThis is How To Calculate Maintenance Calories (Hindi) | Nikhil Nautiyal Fitness In this video I'm going to teach you how you can find your macros in just 5 minutes and then after that you'll be able to calculate your maintenance calories easily. 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Despite countless efforts to combat obesity through diet and exercise, many individuals find it challenging to lose weight and keep it off. In recent years, pharmaceutical interventions have become an increasingly popular option for those struggling with obesity. One such drug, semaglutide, has shown promising results in helping individuals achieve significant weight loss. This article seeks to explore the highest dose of semaglutide for weight loss and how it can maximize effectiveness in aiding weight loss. The Power of Semaglutide Semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that was initially developed for the treatment of type 2 diabetes. However, researchers soon discovered its potential in promoting weight loss and began exploring its efficacy as an anti-obesity medication. Studies have shown that semaglutide can lead to substantial weight loss in individuals with obesity, making it a promising option for those struggling to shed excess pounds. One of the primary ways in which semaglutide promotes weight loss is by reducing appetite and food intake. GLP-1 receptor agonists like semaglutide work by mimicking the effects of GLP-1, a hormone that is released in response to food intake. By activating GLP-1 receptors in the brain, semaglutide can increase feelings of fullness and satiety, helping individuals eat less and ultimately lose weight. In addition to reducing appetite, semaglutide has been shown to have a positive impact on metabolism, leading to increased energy expenditure and fat burning. This can help individuals achieve a calorie deficit more easily, which is essential for weight loss. By targeting both appetite and metabolism, semaglutide offers a comprehensive approach to weight loss that can be highly effective for many individuals. Maximizing Effectiveness When it comes to maximizing the effectiveness of semaglutide for weight loss, the dose plays a crucial role. Studies have shown that higher doses of semaglutide are associated with greater weight loss outcomes, making it essential to find the optimal dose for each individual. The highest dose of semaglutide currently approved for weight loss is 2.4 mg, and research has shown that this dosage can lead to significant and sustained weight loss in individuals with obesity. It is essential to note that the dose of semaglutide should be carefully monitored and adjusted based on individual responses and tolerances. While higher doses may lead to more significant weight loss, they can also increase the risk of side effects such as nausea, diarrhea, and vomiting. Finding the right balance between efficacy and tolerability is key to maximizing the benefits of semaglutide for weight loss. As with any medication, it is essential to consult with a healthcare provider before starting treatment with semaglutide. A healthcare provider can assess your individual needs and goals and help determine the most appropriate dose of semaglutide for your weight loss journey. By working closely with a healthcare provider and monitoring your progress, you can maximize the effectiveness of semaglutide and achieve meaningful weight loss results. Conclusion In conclusion, semaglutide is a powerful medication that can help individuals achieve significant weight loss. By targeting appetite, metabolism, and energy expenditure, semaglutide offers a comprehensive approach to weight loss that can be highly effective for many individuals. When considering the highest dose of semaglutide for weight loss, it is essential to work closely with a healthcare provider to find the optimal dose that balances efficacy and tolerability. With the right dose and support, semaglutide can be a game-changer in the fight against obesity, helping individuals achieve sustainable weight loss and improve their overall health. 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