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A lot of the primary care doctors are starting to recommend glucagon-like peptide-1 (GLP-1) receptor agonists for those patients. But we deal with patients with heart failure with preserved ejection fraction (HFpEF), and a lot of our phenotypes are patients with obesity who happen to have hypertension and/or diabetes, and they are difficult to manage. Inflammation, Obesity, and HFpEF Piña: For today's conversation, there is nobody better than Dr Ambarish Pandey, who has a HFpEF program at the University of Texas Southwestern. Ambarish, welcome. Give me your thoughts overall about the link between obesity, inflammation, and HFpEF. Ambarish Pandey, MD: Thank you, Dr Piña. I'm excited to be on your blog and I'm glad that we are discussing such an important topic. The burden of heart failure, particularly HFpEF, has been increasing and is not just affecting older individuals. 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Pandey: Up to 75% of patients that we see in our program are over the 30 BMI cut-off, and a lot of the literature that has come from US HFpEF cohorts shows a very high average BMI in these patients. Piña: When we talk about inflammation, what are the chemical pathways of inflammation? For example, a long time ago, we tried to block TNF-alpha and it didn't quite work out. So, what pathways are we talking about? Pandey: I think a lot more work needs to be done to really understand the key drivers of inflammation and what pathways are being upregulated. As we know, inflammation is most commonly identified by elevation in levels of C-reactive protein (CRP), which serves as a marker of increased inflammation, but the upstream upregulation in IL-1– and IL-6–mediated pathways has been implicated in inflammation that drives development of diseases like HFpEF. There is an ongoing trial of ziltivekimab, which is an IL-1 inhibitor in patients with HFpEF. That's the HERMES trial led by Paul Ridker, one of the pioneers of inflammatory therapies in heart disease. We are starting to understand more about the key molecular pathways that are driving it. And now we're starting to target them, with the hope that we can actually halt the progression of HFpEF and improve the symptom burden as well as the risk for adverse outcomes in these patients. Are GLP-1 Inhibitors Anti-inflammatory? Piña: Do you think that the GLP-1s, or even now the SGLT2 inhibitors, are anti-inflammatory since we really don't know all the pathways? Pandey: I do think that GLP-1s, by virtue of causing weight loss and reduction in visceral adiposity and the bad fat depots that exist in our body, have a significant anti-inflammatory effect. 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Timestamps 00:00- Intro 01:16- Breakfast recipe #1- Oatmeal 04:38- Lunch recipe #2- Buddha bowl 10:32- Dinner recipe #3- Indian comfort meal Breakfast: Oatmeal (300gm) Ingredients- 30-40 gm Oats 100-150ml Milk ¼ tsp Cinnamon 10-15 gm Mixed seeds 100 to 150gm Fruits 1 scoop Plant protein powder Flavours (optional)- Cocoa Powder, Vanilla essence Lunch: Buddha Bowl- 450gm Ingredients- 30-40 gm Quinoa 30gm Chickpea, soaked 40 gm Paneer 1 tsp Garlic, minced 50 gm Hung curd 1 tsp Olive oil 150 gm Mixed vegetables ½ tsp Chaat masala 2 tsp Chole masala Salt to taste Black pepper powder to taste Fresh coriander leaves, for garnishing Dinner: Indian comfort meal For Dal Tadka Ingredients 30 gm yellow moong dal, soaked 1 tbsp Ghee 1 tsp Jeera 2 pcs Dry red chilli 1 tsp Garlic, chopped 1 tsp Ginger, chopped 2 tbsp Onion, chopped 1 tbsp Tomato, chopped 1 tsp Green chilli, chopped 1 tsp Turmeric powder 1 tsp Coriander powder Salt to taste For Steamed Rice 30gm White rice, soaked Water as required For Soya Masala 30 gm Soya mini chunks 1 tbsp Onion, chopped 1 tbsp Ghee 1 tsp Jeera 2 tbsp Tomato, chopped 1 tsp Sabji masala Salt to taste 1 tsp Turmeric powder ½ tsp Garam masala (optional) Fresh coriander sprig, for garnishing ******************************************************** If you are looking for a customised diet plan then you can join I'MWOW transformation program in which we provide counselling, personalised diet plan, follow along workout videos, recipes, daily positive affirmations, interesting activities and a lot more. 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Through my videos I share my personal experience and learnings through my weight loss journey. I have also completed INFS Nutrition and Fitness course to expand my knowledge on the topic. However, no information shared in the videos is to be taken as medical or other health advice pertaining to any individual's specific health or medical condition. Please consult your healthcare professional before participating in or acting on any recommendation found in content provided on this channel. Diet plans shared under my transformation program are designed by my team of expert, qualified nutritionists. All the products and brands I recommend in my videos are first used/ experienced by me, whether it works for you in the same way or not will solely be your responsibility.Biolyfe Keto Gummies Reviews Evaluating Their Effectiveness And TasteMy day's delightful eats #mounjaro #weightlossgoals #fatlossjourney #fokBe Careful Youtubeshorts Motivation Ytshorts Weightloss Homeworkout Abs Pain Sad GymlifeHello my beloved, I prepared a very delicious and healthy salad today and I wanted to share it with you. recipe 2 tomatoes 1 cucumber 2 kiwis 1 purple onion 1 pinch of dill 1 pinch coriander 1 small bowl of walnuts 4-5 dried apricots 1 pinch of salt 2 tablespoons balsamic sauce 2 tablespoons pomegranate syrup 3 tablespoons of olive oil My dear viewers, I would be very happy if you like the videos and subscribe to my channel. With this, you will help me grow my channel. Specify where you watched it and your thoughts in the comments section. With love🕊️🕊️🕊️Here A 1day Bloating Weightloss Diet Plan Nutritiontips Easynutrition✅ What is Mitolyn? Mitolyn is a cutting-edge dietary supplement formulated to support weight loss and overall health by enhancing mitochondrial function. Mitochondria are often referred to as the powerhouses of our cells, responsible for converting nutrients into energy. A decline in mitochondrial function can lead to weight gain, fatigue, and a host of other health issues. Mitolyn addresses this by utilizing a proprietary blend of six exotic ingredients known to promote healthy mitochondrial levels, ultimately aiding in more efficient fat burning and energy production. Manufactured in the USA with high-quality, non-GMO ingredients, Mitolyn is designed to be an integral part of a healthy lifestyle. The supplement comes in easy-to-swallow capsules, making it accessible to a wide range of users. 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Pregnant or nursing women, as well as individuals with underlying health conditions or those taking medications, should consult with a healthcare professional prior to starting any new supplement regimen. Overall, while side effects are relatively rare, being aware of your body’s response to Mitolyn is essential. If you experience any adverse reactions, it is recommended to discontinue use and consult a healthcare provider for guidance. By taking these precautions, users can safely enjoy the benefits of Mitolyn while minimizing the risk of side effects. ✅ Who makes Mitolyn? Mitolyn is produced by a reputable company dedicated to creating high-quality dietary supplements. The brand is committed to using premium ingredients sourced from trusted suppliers, ensuring that each product meets stringent quality standards. By manufacturing in the USA, Mitolyn adheres to strict regulations and safety protocols, providing customers with confidence in the products they consume. 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The 'I Am Jazz' star reveals she lost 70 pounds, after opening up on her 'TLC' reality series about struggling with a binge-eating disorder.The Episode That Made Them Famous Shark Tanks Keto Acv Gummies Understanding the Keto Diet and Gallbladder Removal The ketogenic diet, commonly known as the keto diet, has garnered significant attention due to its potential benefits for weight loss, managing diabetes, and improving overall health. This high-fat, very-low-carbohydrate diet encourages the body to enter a state of ketosis, where it burns fat for fuel instead of carbohydrates. However, for individuals who have undergone gallbladder removal – a procedure often necessitated by gallstones, bile duct obstructions, or other digestive issues – adopting a keto diet presents unique challenges. The gallbladder plays a crucial role in digestion, specifically in the emulsification and absorption of fats. Thus, those without a gallbladder must approach the keto diet with caution and knowledge to ensure successful adherence and to maintain digestive health. Initially, when embarking on the keto lifestyle post-gallbladder removal, it is vital to understand the implications of lacking this organ. Without a gallbladder, the body can still digest fat; however, the process may be less efficient. The gallbladder’s primary role is to store bile – a digestive fluid produced by the liver that helps to break down fat. When the gallbladder is absent, bile is constantly secreted into the small intestine in smaller amounts, rather than being released in concentrated bursts during meals. This can lead to difficulties in fat digestion, potential digestive discomfort, and a risk of developing diarrhea or other gastrointestinal issues. As such, for those considering the keto diet after gallbladder removal, it is essential to adapt their approach to fat consumption. This may involve selecting specific types of fats that are easier to digest, pacing dietary fat intake throughout the day, and possibly incorporating supplements to support digestion. Consulting healthcare professionals such as dietitians or nutritionists who understand the intricacies of dietary fat digestion can provide personalized guidance tailored to individual needs. This article will delve into safe and effective strategies for successfully navigating the keto diet without a gallbladder, ensuring that health goals can be met without compromising digestive well-being. Choose Healthy Fats Wisely When adopting a ketogenic diet, the types of fats consumed are crucial, particularly for individuals without a gallbladder. Healthy fats should be prioritized, as they tend to be more easily digested and absorbed, minimizing the risk of gastrointestinal issues. Sources of healthy fats include avocados, olive oil, coconut oil, and fatty fish like salmon. These fats are not only beneficial for maintaining ketosis but are also rich in omega-3 fatty acids, which have anti-inflammatory properties and are essential for overall health. Conversely, certain fats may exacerbate digestive issues. For instance, trans fats and overly processed oils can lead to discomfort and should be avoided. Additionally, saturated fats, while often included in keto diets, may not be as well-tolerated for those who have had gallbladder surgery. It may be wise to experiment with different fats, keeping a food diary to monitor how each type affects digestion and overall comfort after meals. Incorporating digestive aids may also help when consuming dietary fat. Enzyme supplements that contain bile salts can assist with fat digestion, enhancing absorption and reducing symptoms like bloating or diarrhea. These supplements should be discussed with a healthcare provider to ensure they are appropriate for the individual’s needs, and to determine the correct dosages. Portion Control: Pacing Your Fat Intake For those without a gallbladder, managing portion sizes is critical when following a ketogenic diet. Instead of consuming large amounts of fat in one sitting, it may be beneficial to space fat intake throughout the day. Smaller, frequent meals can help optimize fat digestion, allowing the body to adapt to the constant flow of bile into the small intestine. This method can prevent overwhelm on the digestive system and minimize unpleasant symptoms. Another effective strategy is to combine fats with protein and fiber-rich foods. For instance, pairing avocado with eggs or adding nuts to a salad can help slow the digestion of fats, facilitating better absorption. This not only provides a balanced macronutrient profile but may also enhance satiety, keeping hunger at bay and preventing the urge to snack on potentially problematic high-carb foods. Paying close attention to hunger signals is also essential. Eating mindfully and recognizing the body’s cues can help individuals adjust their food intake appropriately. Sometimes, feelings of hunger may indicate the need for more substantial carbohydrates or proteins rather than just increasing fat intake. Keeping track of food intake and how the body feels afterward can help fine-tune dietary habits suited to being keto without a gallbladder. Support Your Digestive System The digestive system can experience significant changes after gallbladder removal, especially when adopting a diet rich in fats like the keto diet. To support digestive health, incorporating fiber-rich foods is imperative. While the keto diet typically limits many high-fiber carbohydrates, there are still options available, including low-carb vegetables such as spinach, broccoli, and cauliflower. These not only provide essential nutrients but also aid in digestion and can prevent constipation, which may be a concern for some post-surgery. Probiotics can also play a significant role in maintaining healthy gut flora. Opting for fermented foods like sauerkraut, kimchi, and full-fat yogurt (watching sugar content) can promote a balanced gut microbiome, which is integral to good digestion and overall health. In addition, probiotic supplements can be considered; these should be chosen carefully with guidance from a healthcare provider to ensure effectiveness. Staying hydrated is equally important in supporting digestive health. Drinking adequate amounts of fluids, ideally water, encourages good digestion and helps prevent constipation. As certain keto-specific foods can be dehydrating, particularly those that are high in protein, ensuring optimal hydration can enhance overall well-being and support proper digestive processes. Monitor Your Body’s Responses Regularly monitoring how your body responds to dietary changes is critical when following a ketogenic diet without a gallbladder. Keeping a detailed journal to track food intake, symptoms, and overall well-being can provide invaluable insights. This record can help you identify specific foods that may cause discomfort or adverse reactions, allowing you to tailor the diet to your needs effectively. Furthermore, understanding and accepting that everyone’s digestive system reacts differently is key. What works for one individual may not work for another, requiring some trial and error. Consultations with healthcare professionals can offer additional insights into optimizing the diet and addressing any concerns, ensuring that health goals are met safely. As the body adjusts to the ketogenic diet, paying close attention to mood, energy levels, and digestive health is important. Unusual fatigue, cravings, or persistent digestive issues should not be ignored and warrant a reassessment of eating habits. Seeking support from peer groups or professionals can also foster encouragement and provide practical tips for navigating the dietary landscape post-gallbladder. Be Patient and Adaptable <pEmbarking on a ketogenic diet without a gallbladder requires patience and adaptability. It may take time for the digestive system to adjust to higher fat intake, and individuals may need to experiment with various foods and meal timings before finding what works best. This journey is not just about adherence to a diet; it's about fostering a sustainable lifestyle change that aligns with personal health goals. Being adaptable includes remaining open to adjusting macronutrient ratios or meal structures based on individual responses. For some individuals, this may involve slightly increasing carbohydrate intake while still maintaining ketosis, especially if high fat consumption leads to digestive discomfort. Understanding that the body can produce energy through various means can ease frustration around strict adherence to fat ratios. Lastly, staying informed and educated about both the keto diet and its implications for those without a gallbladder can empower individuals. Engaging in community support through online forums or local groups focused on low-carb eating can provide motivation, share experiences, and offer valuable recipes tailored to dietary needs. Above all, embracing a positive mindset and celebrating small victories can enhance the journey toward health and vitality. Summarizing Strategies for Keto Success Adopting a ketogenic diet without a gallbladder can present unique challenges, but by implementing effective strategies, success is entirely achievable. Key takeaways include the importance of selecting healthy fat sources, pacing fat intake through portion control, and supporting digestive health with adequate fiber, hydration, and probiotics. Monitoring the body’s responses and being adaptable to changes are also crucial for long-term success. As people navigate this journey, seeking professional guidance from dietitians or nutritionists who specialize in low-carb diets can provide tailored support. They can help with meal planning, food choices, and supplements that may enhance digestion. Additionally, engaging in conversations within keto communities can offer shared knowledge and encouragement, making the transition smoother. Overall, patience and perseverance are essential. It is crucial to remember that individual experiences will vary, and the path to success requires an understanding of one’s body. By adhering to these strategies and staying committed to health goals, incorporating a keto lifestyle without a gallbladder can lead to improved well-being, sustained energy levels, and a renewed sense of vitality. 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