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In this fascinating episode of the Huberman Lab Podcast, Andrew Huberman and Dr. Zachary Knight delve into the science behind GLP-1 (Glucagon-Like Peptide-1) and its powerful role in appetite control. They explore the backstory of how this peptide, inspired by a Gila monster’s biology, has revolutionized appetite suppression in humans. With drugs like Ozempic and Monjaro becoming popular for weight management, Dr. Knight explains how GLP-1 functions within the body and brain to reduce hunger and cravings. They also discuss the discovery of this peptide, its effects on animals like the Gila monster, and how researchers have leveraged this knowledge to create treatments that help people manage their appetite and weight. If you're curious about how GLP-1 works and the future of appetite regulation, this episode offers deep insights into the science and potential applications.

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'𝐁𝐮𝐫𝐧𝐢𝐧𝐠 𝐟𝐚𝐭' 𝐝𝐮𝐫𝐢𝐧𝐠 𝐲𝐨𝐮𝐫 𝐰𝐨𝐫𝐤𝐨𝐮𝐭? 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 𝐬𝐡𝐨𝐰𝐬 𝐲𝐨𝐮 𝐦𝐢𝐠𝐡𝐭 𝐛𝐞 𝐰𝐚𝐬𝐭𝐢𝐧𝐠 𝐲𝐨𝐮𝐫 𝐭𝐢𝐦𝐞 𝐢𝐧 𝐭𝐡𝐞 '𝐟𝐚𝐭-𝐛𝐮𝐫𝐧𝐢𝐧𝐠 𝐳𝐨𝐧𝐞'... 🤯 Day 12 of my “Metabolism Metrics” series, a series covering the metrics I routinely quantify into numbers and track in both myself and my clients for optimal metabolic health...as well as the science behind each of them. The 'fat-burning zone' might be the biggest myth in fitness - here's what your body is REALLY doing 🔬 Most people think staying in the 'fat-burning zone' is the key to losing fat. But here's the uncomfortable truth: Your body's ability to burn fat isn't about exercise intensity - it's about metabolic flexibility. 𝐓𝐡𝐞 𝐑𝐄𝐀𝐋 𝐬𝐭𝐨𝐫𝐲 𝐚𝐛𝐨𝐮𝐭 𝐟𝐚𝐭-𝐛𝐮𝐫𝐧𝐢𝐧𝐠 𝐞𝐟𝐟𝐢𝐜𝐢𝐞𝐧𝐜𝐲: • It's a marker of cellular health • It shows how well your mitochondria function • It predicts your long-term health • It determines how your body uses food Why this ACTUALLY matters: The higher your fat-burning efficiency, the better your cells can use fat as fuel. This means you're less likely to store excess calories as fat, even when you're not exercising. ⚠️ 𝗪𝐡𝐚𝐭'𝐬 𝐝𝐞𝐬𝐭𝐫𝐨𝐲𝐢𝐧𝐠 𝐲𝐨𝐮𝐫 𝐟𝐚𝐭-𝐛𝐮𝐫𝐧𝐢𝐧𝐠 𝐩𝐨𝐭𝐞𝐧𝐭𝐢𝐚𝐥: • Processed foods • Lack of training • Overtraining syndrome This subject was voted for me to cover by 'The Fittest Forum'. Join for free through the link on my Instagram profile page to have a say in what subject I create and educate you on next. Coming tomorrow: The shocking truth about movement economy and why efficiency might be your enemy. 🫶🏾 Dr. Nick #metabolichealth

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Can semaglutide and hormone replacement therapy (HRT) work together for weight loss? Dr. Charles Mok explains the role of semaglutide and HRT in supporting medical weight loss. He outlines how semaglutide helps individuals with diabetes manage weight and explores the link between obesity and diabetes. Dr. Mok also discusses how to optimize dosing, enhance treatment effectiveness, and whether combining HRT with GLP-1 therapy may improve weight loss outcomes. Don’t miss out on the full episode of Inside The Cure Podcast: Semaglutide and Hormone Replacement Therapy For Weight Loss. https://youtu.be/DvVk2KdHjKA #GLP1Therapy #HormoneReplacementTherapy #WeightLoss

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Are love handles holding you back from feeling your best? This workout is here to help you burn fat and sculpt a more defined waist with just 13 moves. A no-equipment routine that will target your side fat while also toning your core. We have 4 phases for our workout today as these phases provides a structured approach for targeting your love handles. This is done by combining strength training, core activation, leg work, and dynamic movements. The first Phase is your Core Activation & Strengthening, designed to engage and strengthen your core and side muscles, primarily targeting your obliques. This will set the tone for engaging your love handles. Phase 2 is Leg and Glute Activation. This is added to activate your lower body. It complements the core work for overall fat loss and muscle shaping. Phase 3 is Dynamic Core and Full-Body Engagement. This provides functional core tone. It will also build stability over time. Last Phase is your Core Finisher & Flexibility. The goal is to maximize the effect, ensuring muscles are fully engaged and fatigued by doing repetitions until the end of the session. With each rep you do, you're one step closer to your dream goals! Goodbye to love handles! Keep working on your routine, it's all about patience and consistency with workouts like this. Soon you'll see the results that you've beein working on. Just keep pushing! Good luck and have fun! ❤️💪 _**Don’t forget to share your experience and progress in the comment section. If you want to be notified when I upload a new video, make sure to subscribe to our channel. I upload new videos everyday from Monday to Saturday!_ ========================================== Stay connected on my other social media platforms so you can share your journey with others and stay motivated! *Instagram:* https://www.instagram.com/robertasgym/ *TikTok:* https://www.tiktok.com/@robertasgym *Reddit:* https://www.reddit.com/user/robertasgym/ *Twitter:* https://x.com/robertasgym *Tumblr:* https://www.tumblr.com/blog/robertasgym *Wordpress:* https://robertasgym.com/ Let’s keep the motivation going! 💪 ========================================== *TIMECODES:* 00:00 Introduction 00:11 Side Plank Pulse Left 00:38 Side Plank Pulse Right 01:06 Rest 01:24 Side Leg Raise Left 01:57 Side Leg Raise Right 02:31 Rest 02:49 Diagonal Abs Left 03:18 Diagonal Abs Right 03:48 Rest 04:06 Side Crunches Left 04:36 Side Crunches Right 05:07 Rest 05:25 Waist Pinchers Left 05:52 Waist Pinchers Right 06:21 Rest 06:39 Step Back Jacks 07:00 Rest 07:18 Knee Stretch Left 08:09 Knee Stretch Right 08:59 Rest 09:17 Thigh Stretch Left 10:08 Thigh Stretch Right 10:58 Rest 11:16 T Plank 12:07 Rest 12:25 Russian Twist 12:45 Rest 13:03 Side Lunge Windmill 13:27 Rest 13:45 Bird Dog 14:35 Rest 14:53 Knee Tuck Crunch 15:24 Rest 15:42 Side Plank Pulse Left 16:09 Side Plank Pulse Right 16:36 Rest 16:54 Side Leg Raise Left 17:28 Side Leg Raise Right 18:02 Rest 18:20 Diagonal Abs Left 18:49 Diagonal Abs Right 19:19 Rest 19:37 Side Crunches Left 20:07 Side Crunches Right 20:37 Rest 20:55 Waist Pinchers Left 21:23 Waist Pinchers Right 21:51 Rest 22:09 Step Back Jacks 22:31 Rest 22:49 Knee Stretch Left 23:40 Knee Stretch Right 24:30 Rest 24:48 Thigh Stretch Left 25:38 Thigh Stretch Right 26:29 Rest 26:47 T Plank 27:37 Rest 27:55 Russian Twist 28:15 Rest 28:33 Side Lunge Windmill 28:58 Rest 29:16 Bird Dog 30:06 Rest 30:24 Knee Tuck Crunch

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