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The majority of fat in our bodies resides in fat cells. These cells are made up of roughly 15% lean mass and 85% fat, in the form of a lipid droplet. To use this fat we must get it to cross over the cell membrane of the fat cell. This process is called lipolysis. An enzyme called hormone-sensitive lipase takes a triglyceride, the fat in the cell, and separates the three fatty acids from the glycerol. This frees the fatty acids to pass through the cell membrane to be made available to the Krebs Cycle. So to use your stored fats as fuel, you need to produce hormone-sensitive lipase. Many hormones are involved here, but the one that you want to be most concerned with is insulin. If you have high levels of insulin in your blood, you are going to have low levels of lipase. Dietary carbohydrates are the main contributor to your blood insulin levels. So how do we burn our stored fat? The Krebs Cycle: You may remember from biology class the Citric Acid Cycle, also known as the Krebs cycle. Mitochondria are found in the hundreds to thousands in all cells in our body (except mature red blood cells). Here, energy from what we eat, the carbohydrates, fats and proteins, are converted into ATP. Acetyl COA is used to form the energy, or ATP, in the Krebs cycle: If you are consuming carbohydrates or eating too frequently, your blood is going to have high insulin levels and there will be carbohydrates that you have recently eaten available as the fuel for the Krebs Cycle. Traditionally, carbohydrates that you eat are broken down in your body. The glucose undergoes a process called glycolysis and pyruvate is formed. In the mitochondrial matrix, pyruvate undergoes oxidation and ACOA is formed. ACOA can also be formed from the breakdown of fats and amino acids, or the building blocks of proteins. How your body uses its energy is dependent upon what you eat. Traditionally, when you are in a normal state, your body is using carbohydrates for their main energy source through the citric acid cycle. If you change how you eat, you can train your body to instead form ACOA through the breakdown of ketone bodies. How Does it Work? When glucose is in short supply, your body begins lipolysis. These free fatty acids, rather than carbohydrates from your food, are used to produce ACOA. Once the fatty acids have been released into your bloodstream, they bind to a protein called albumin. Albumin shuttles the fatty acids to the muscle cells where they are taken into the mitochondria as ACOA. In very fit athletes the muscle cells themselves will begin to store the lipid droplets in them rather than glucose for immediate energy fuel. Lipogenesis: When you eat carbohydrates, they break down into glucose in your blood. The pancreas secretes insulin to shuttle the glucose out of the blood and into either the muscle or liver for immediate use, glycogen storage, or they be stored as fat. Your liver and muscle cells have a limited capacity for glycogen storage that is not very high. This means that when you consume excess carbs your body has to store them as fat through a process called lipogenesis. Simply put, lipogenesis is the creation of fatty acids from carbohydrates that you consume. While for our ancestors in the hunting and gathering days this storage of energy was great, in the age of abundance we are struggling with the health impacts of storing excess fat. This fat storage follows a process very similar to the Krebs Cycle discussed. Once the ACOA is created, if the body does not need to use it for energy or for storage in the muscles and liver, it is stored through lipogenesis as fat for later use. References: 1. The Citric Acid Cycle https://www.khanacademy.org/science/biology/cellular-respiration-and-fermentation/pyruvate-oxidation-and-the-citric-acid-cycle/a/the-citric-acid-cycle 2. The citric acid cycle oxidized two-carbon units http://www.ncbi.nlm.nih.gov/books/NBK22427/ 3. What is Ketosis? Our article :) 4. Fat Breakdown and Fat Burning: Lipolysis and Oxidation http://leanmessengers.com/fat-breakdown-and-fat-burning-lipolysis-and-oxidation/ 5. How and what am I digesting? A breakdown of macronutrient… http://leanmessengers.com/?s=lipogenesis 6. Lipid catabolism summary http://chemistry.elmhurst.edu/vchembook/622overview.html 7. Acetyl COA - Crossroads Compound http://chemistry.elmhurst.edu/vchembook/623acetylCoAfate.htmlWeight Loss Is A Scam Don T Get Trapped Scammers Weightloss Weightlosssupplement Trapped VohcERROR CORRECTION: Please note that the video is a single take and sometimes I misspeak. The following are some corrections: 4:32 – GLP-1 is GLYCOGEN-LIKE PEPTIDE-1 NOT GLUCOSE-LP-1 4:40 GLP-1 also blocks GLUCAGON release and reduces liver release of glucose and gluconeogenesis reducing BG 5:52 GLP-1 medications are RECEPTOR AGONISTS IMHO GLP-1 agonists are the single most effective and best medications currently on the market when combined with a LOW CARB way of life to correct INSULIN RESISTANCE for ROOKIES, folks STRANDED despite doing all they can, and for KETO-CARNIVORE VETERANS who are profoundly INSULN SUPPRESSED The references below and the general consensus is to focus on blood glucose but the primary purpose is to CORRECT INSULIN RESISTANCE. Most folks are overly focused on BG and do not even understand the central role of INSULIN RESISTANCE in METABOLIC DISEASE Know the scientific truth about how your body works. Research Discussed... User's guide to mechanism of action and clinical use of GLP-1 receptor agonists. Shaefer CF Jr, Kushner P, Aguilar R.Postgrad Med. 2015;127(8):818-26 A review of GLP-1 receptor agonists in type 2 diabetes: A focus on the mechanism of action of once-weekly agents. Cornell S.J Clin Pharm Ther. 2020 Sep;45 Suppl 1(Suppl 1):17-27 The evolving story of incretins (GIP and GLP-1) in metabolic and cardiovascular disease: A pathophysiological update. Nauck MA, Quast DR, Wefers J, Pfeiffer AFH.Diabetes Obes Metab. 2021 Sep;23 Suppl 3:5-29 My Websites: https://www.obesityunderstood.com https://www.weighlitepro.com We try to keep this content free as a service to you. If our content resonates and you can afford a buck or more: Donate to our 501(c)3 NON-PROFIT CHARITABLE ORGANIZATION PayPal ▶[email protected] PATREON ▶ https://bit.ly/2Xj0gBm WHERE TO FIND DR. ROBERT CYWES and SHERYL FOX RD: YouTube: https://www.youtube.com/channel/UCk4M... INSTAGRAM: https://www.instagram.com/carbaddicti... FACEBOOK: https://www.facebook.com/robertcywes/ or https://www.facebook.com/carbaddictiondoc/ TIKTOK: https://www.tiktok.com/@carbaddictiondoc ROBERT CYWES M.D., PhD and SHERYL FOX RD ARE clinically PRACTICIONERS in Florida and COVER THE ENTIRE USA AND WORLD VIA TELEHEALTH. The mission of our media content is educating the public about a CARBOHYDRATE ADDICTION approach to treating obesity, diabetes and metabolic syndrome. Understanding the importance of replacing carbs in your diet with REAL FOOD while simultaneously replacing carbs as a toxic, harmful response to emotional tension with a more effective diverse healthy set of emotion management tools for lifelong sustainability of mental and physical health, happiness and well-being. Converting people from toxic sugar burners to healthy fat (keto) burners while addressing the CAUSE of addiction to carbs from an emotion management perspective. Sometimes using obesity surgery and devices as tools along the way, and helping people who have had bariatric surgery stay healthy and not relapse Set up a consultation if you are looking for more sustainable ways to treat obesity, diabetes, metabolic syndrome, cholesterol issues and thyroid disease. Even if you are doing great but need physician confirmation or if you are considering or struggling after Bariatric Surgery we can assist you getting back on track. TEXT, WHATSAPP or CALL to leave a message on our “batphone” +1 5615170642 from anywhere in the world. We do secure telehealth, Zoom and Whatsapp phone and video consults all over the world. If appropriate we can order bloodwork and Coronary Artery Calcium Scores as part of a consultation. Please always feel free to record your consult but inform Dr Cywes and Sheryl. For COLLABORATIONS please email me: [email protected] **DISCLAIMER: Any information on diseases and treatments available at this channel is intended for general guidance only and must never be considered a substitute for advice provided by a doctor or other qualified healthcare professional. Always seek the advice of your physician or other qualified health care professional with questions you may have regarding your medical condition. This site and these videos exist to provide information and support about nutritional health and do not provide medical advice and should not be thought to provide medical advice. We can only give medical advice if you establish yourself as a registered patient and consult with us in our medical practice - JSAPA. We always recommend working with a team of knowledgeable and experienced practitioners, including a physician such as Dr Cywes and a Registered Dietician such as Sheryl Fox in our practice. Do not self-diagnose. Always seek medical guidance when you have a medical condition. -------- #diabetes #insulinsensitivity #keto #insulinresistance #insulinresistance #GLP-1 #victoza #trulicity #ozempicMorning Shake Boost Keto KetonesforfuelLosing over 60 lbs! Belly fat & love handles are disappearing! Weightloss and wellness journey support!! Let's motivate and share our success and learn from each other along the way!! positive vibes all the way!!! Thanks for watching. Please like, share, and subscribe. #fatburning #losebellyfat #fitnessJourney #workout motivation #weightloss #burnfatfast #homeworkout #strongandfit #healthylifestyle #fitmom #fitnessgoals #ThisWorks #girlpower#bellyfat #keto #Bodyfordays #fast #food #bodybuildingDiabetic Life Keto Aesthetic Diabetic Ketodiet Are you looking to optimize your keto diet and boost your weight loss efforts? 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