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Pfizer on Friday said it would stop developing the twice-daily version of its experimental weight loss pill after obese patients taking the drug lost weight but had trouble tolerating the drug in a mid-stage clinical study. The drugmaker observed high rates of adverse side effects, which were mostly mild and gastrointestinal, among patients. A significant share of patients also stopped taking the drug in the trial."At this time, twice-daily danuglipron formulation will not advance into Phase 3 studies," the company said. But Pfizer said it still plans to release phase two trial data on a once-a-day version of the drug in the first half of 2024, which will "inform a path forward." The pharmaceutical giant will wait to see that data before deciding whether to start a phase three study on the once-daily pill, which Wall Street views as the more competitive form of the treatment. Still, the data on the twice-daily drug is a blow to Pfizer's hopes to win a $10 billion slice of the booming weight loss drug market, which CEO Albert Bourla has said could grow to $90 billion. The company is betting on a successful weight loss pill to help it rebound from plummeting demand for its Covid products and a roughly 40% share price drop this year. But investors have been pessimistic about Pfizer's potential in the weight loss drug space since the company scrapped a different once-daily pill in June and proceeded with the less attractive danuglipron. Now, Friday's data puts Pfizer even further behind the dominant players in the weight loss drug market, Eli Lilly and Novo Nordisk, which are racing to develop more convenient pill versions of their blockbuster weight loss and diabetes injections. Pfizer's phase two trial on its twice-daily pill followed around 600 obese adults who did not have Type 2 diabetes. The trial examined the drug's effect on weight loss after 26 or 32 weeks, at different dosage amounts ranging from 40 milligrams to 200 milligrams. Like Novo Nordisk's Wegovy and Ozempic, Pfizer's pill works by mimicking a hormone produced in the gut called GLP-1, which signals to the brain when a person is full. All dose sizes of Pfizer's pill showed "statistically significant reductions" in body weight ranging from 6.9% to 11.7% at 32 weeks, and from 4.8% to 9.4% at 26 weeks. Meanwhile, patients on a placebo lost 8% to 13% of their body weight at 32 weeks and 5% to 9.5% at 26 weeks, Pfizer said. The company said high rates of adverse events were observed among patients in the study, with up to 73% experiencing nausea, up to 47% vomiting and up to 25% experiencing diarrhea. More than 50% of patients across all dose sizes stopped taking the pill, compared to roughly 40% among those on the placebo, according to Pfizer. No new safety issues were observed, and danuglipron was not associated with increased liver enzymes like Pfizer's other discontinued weight loss pill. All data is taken from the source: http://cnbc.com Article Link: https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html #weight #newshour #newstodayheadlines #newstodayfox #newstodayupdate #newstodayworld #

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Anyone who has watched even one episode of ABC’s hit reality show Shark Tank knows that its producers are constantly searching for entrepreneurs who have his or her own ideas to sell to a panel of wealthy investors. The show consistently gets good ratings, as the pitching process can be pretty entertaining to watch and many of the products are intriguing, such as the biohacking pill segmented from a jellyfish in a previous TV episode. Moreover, because the show is broadcast on network television, it makes it easy for non-experts to discover intriguing new diets via the ‘As Seen On TV’ feature that runs on the side of the television screen while the show plays. No one will forget the commissioner of Keto Animals, which aired in the October 2022 episode of the show. This example showcased an entrepreneur pitching a keto-friendly product to the investors. Hey, up there, did any viewers experience any keto headaches when exposed to these dietary ideas in the show? What happens behind the scenes as production gets these episodes ready for broadcast? In this article we explore the top episodes in the Shark Tank series featuring a keto product, as well as some behind-the-scenes facts about how the show is made.

The Keto Product Pitch

Seeking a super-charged and lucrative deal, the product’s inventor entered the Tell All Shark Tank, awaiting scrutiny from the panel of investors – each with their own financial needs and business acumen. ‘Your keto product is different,’ says the top Shark on the panel, who asks probing questions about ingredients and manufacturing process of the product and its competitive advantage in the health and wellness industry.

The pitch ran for several minutes as the sharks wrangled over its scalability and sales projections. Some felt like keto was a fad with limited staying power; others sensed potential for a niche market to scale up big. Overall, the entrepreneur in question left an impression, prompting a bidding war for a percentage of the keto product.

Eventually, a deal was made, and the entrepreneur ended up with a deal that would help take their business to new heights. The keto product Shark Tank episode not only provided entertainment for those of us watching, it also was likely a conduit for information about the benefits of the keto diet and the potential for entrepreneurship to spur new diet innovations for health and wellness.

Behind the Scenes Insights

A team of producers, directors and crew are working on the opposite side of the Shark Tank set. While the investors tease each other and bide the 30 seconds that a contestant has to make their pitch, another set of producers are crafting those 30-second pitches from the footage they shoot around the country. Cameramen put in countless hours scouting entrepreneurs across the country and asking creative questions to generate talking points. The whole apparatus is geared toward making the episode as entertaining and interesting as possible.

It’s the day of filming, and entrepreneurs about to pitch their businesses and investors warming up to grade the next big idea. The electricity in the room crackles as pitch is made and equity traded, cameras rolling so viewers at home can watch the show.

Once both the entrepreneur and the investors agree to move forward, the real work begins. Both parties have to do due diligence – the entrepreneur has to clean up her act, hire a team, buy or lease a facility, and finalise the legal deal structure. The show might be over, but the cameras have stopped running, and the truly difficult work of making a pitch go from show to reality must begin.

Impact of the Show

If an entrepreneur’s business gets enough traction on Shark Tank, that exposure can jumpstart the business’s momentum, leading to new opportunities for further growth. In the case of the keto product, sales and interest spiked after its appearance in The Shark Tank as viewers flocked to learn more about the health and wellness offering.

For anybody watching from home, aspiring to be an entrepreneur – and for many who are – Shark Tank is about dreaming big, and about thinking outside the box when it comes to the business idea. Its success stories, and its many ‘don’t do what I did; do what I say you should’ moments, make the process of business seem possible.

In conclusion, the entrepreneurial spirit of the keto product presented on Shark Tank shows that innovation, passion and teamwork can make or break a business. The show inspires up-and-coming entrepreneurs while giving viewers something to look forward to each week.

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When Pure Keto appeared on Shark Tank, the popular reality TV show where entrepreneurs pitch their products to potential investors, it gained significant exposure and sparked a lot of interest in the ketogenic diet community. Pure Keto is a dietary supplement that claims to help individuals achieve ketosis more quickly and easily, leading to faster weight loss and improved overall health. The founders of Pure Keto were seeking an investment to help take their product to the next level, but did they succeed? Let’s take a closer look at the benefits and criticisms of Pure Keto’s appearance on Shark Tank.

Benefits of Pure Keto’s Exposure on Shark Tank

One of the biggest benefits of appearing on Shark Tank is the exposure it provides to a massive audience. The show has a large and dedicated following, so when a product is featured, it can generate a significant amount of buzz and interest. This increased visibility can help boost sales and awareness of the product, leading to potential growth and success for the company.

Additionally, appearing on Shark Tank gives entrepreneurs the opportunity to pitch their product to a panel of successful business moguls who have a wealth of knowledge and experience. The feedback and advice given by the sharks can be invaluable, helping the founders of Pure Keto improve their product, business model, and overall strategy. This guidance and mentorship can be instrumental in taking the company to the next level.

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Another benefit of appearing on Shark Tank is the potential for securing a deal with one of the investors. Landing an investment from one of the sharks can provide the capital and resources needed to scale the business, increase production, launch new marketing campaigns, and expand into new markets. This financial backing and partnership can be a game-changer for the company and help drive its growth and success.

Criticisms of Pure Keto’s Exposure on Shark Tank

One of the criticisms of Pure Keto’s appearance on Shark Tank is the skepticism surrounding the effectiveness and safety of the product. The ketogenic diet has gained popularity in recent years for its potential weight loss benefits, but some experts have raised concerns about the long-term health effects of following a high-fat, low-carb diet. Critics argue that relying on supplements like Pure Keto to achieve ketosis may not be sustainable or healthy in the long run.

Another criticism of Pure Keto’s exposure on Shark Tank is the potential for false advertising and exaggerated claims. Some viewers have questioned the legitimacy of the product’s claims and wonder if it can really deliver on its promises of rapid weight loss and improved health. The founders of Pure Keto may face backlash if they are unable to substantiate their claims with scientific evidence or customer testimonials.

Additionally, appearing on Shark Tank can be a double-edged sword for entrepreneurs, as the intense scrutiny and pressure from the sharks can be intimidating and challenging. The investors are known for their tough questions and high standards, and not every company that appears on the show receives a deal. The founders of Pure Keto may have faced tough questions about their product’s ingredients, formulation, and competitive positioning, which could have made their pitch more difficult.

Overall, Pure Keto’s exposure on Shark Tank has both benefits and criticisms. While the increased visibility and potential for investment are valuable opportunities, the skepticism surrounding the product’s effectiveness and the pressure of pitching to the sharks are important factors to consider. Only time will tell if Pure Keto can capitalize on its appearance on the show and achieve sustainable growth and success.

Summary and FAQ

In summary, Pure Keto’s appearance on Shark Tank generated significant buzz and interest in the ketogenic diet community, but it also raised concerns about the product’s effectiveness and safety. While the exposure and potential for investment are valuable opportunities, the skepticism and scrutiny surrounding the product are important factors to consider. Ultimately, only time will tell if Pure Keto can capitalize on its appearance on the show and achieve sustainable growth and success.

Here are some frequently asked questions about Pure Keto and its exposure on Shark Tank:

1. What is Pure Keto?

Pure Keto is a dietary supplement that claims to help individuals achieve ketosis more quickly and easily, leading to faster weight loss and improved overall health.

2. What are the benefits of appearing on Shark Tank?

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Appearing on Shark Tank can provide increased visibility, valuable feedback and advice from successful business moguls, and the potential for securing an investment to help scale the business.

3. What are the criticisms of Pure Keto’s exposure on Shark Tank?

Criticisms include skepticism about the product’s effectiveness and safety, concerns about false advertising and exaggerated claims, and the pressure and scrutiny of pitching to the sharks.

4. Will Pure Keto be able to achieve sustainable growth and success following its appearance on Shark Tank?

Only time will tell if Pure Keto can capitalize on its exposure on Shark Tank and overcome the criticisms and challenges it may face moving forward.

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Semaglutide is a medication that has been making waves in the weight loss community for its impressive results. It is a glucagon-like peptide-1 (GLP-1) receptor agonist that works by increasing feelings of fullness, reducing appetite, and slowing down the stomach from emptying. This medication is typically used to treat type 2 diabetes, but it has also been found to be effective in promoting weight loss in individuals who are overweight or obese. Many people have shared their real-life results of using semaglutide for weight loss, showing significant transformations and improvements in their overall health.

Personal Experiences

One individual shared their journey of using semaglutide for weight loss on social media, detailing how they struggled with their weight for years before deciding to try this medication. They described feeling more in control of their eating habits and experiencing fewer cravings since starting semaglutide. Additionally, they mentioned feeling more energized and motivated to exercise regularly, which has contributed to their weight loss success.

Another person who tried semaglutide for weight loss talked about how it helped them break through a weight loss plateau that they had been stuck in for months. They noticed a significant decrease in their appetite and found it easier to resist unhealthy food cravings. This individual also mentioned feeling more confident and positive about their body image, thanks to the progress they have made with semaglutide.





One user shared how semaglutide not only helped them lose weight but also improved their overall well-being. They reported feeling more comfortable in their own skin and having higher self-esteem since starting this medication. This person also highlighted the importance of maintaining a healthy lifestyle alongside taking semaglutide to achieve long-lasting weight loss results.

Side Effects

While many people have seen positive results with semaglutide for weight loss, it is essential to consider the potential side effects of this medication. Some individuals have reported experiencing nausea, diarrhea, and vomiting when first starting semaglutide. These side effects typically subside over time as the body adjusts to the medication, but it is essential to talk to a healthcare provider if they persist or worsen.

Another possible side effect of semaglutide is low blood sugar levels, especially in individuals who are taking other medications that lower blood sugar. It is crucial to monitor blood sugar levels regularly when using semaglutide and make adjustments to medication as needed to prevent hypoglycemia. Additionally, some people may experience injection site reactions, such as redness or swelling, which are usually mild and temporary.

It is essential to be aware of the potential side effects of semaglutide and discuss any concerns with a healthcare provider before starting this medication. While the side effects can be challenging to manage initially, many people find that they diminish over time, and the benefits of weight loss with semaglutide outweigh the temporary discomfort.

Maintaining Results

Once individuals have achieved their weight loss goals with semaglutide, it is essential to focus on maintaining these results long term. Many people find success in maintaining their weight loss by continuing to follow a healthy diet, incorporating regular exercise into their routine, and staying consistent with taking semaglutide as prescribed. It is also crucial to monitor weight regularly and make adjustments as needed to prevent regain.

Some individuals find that attending support groups or seeking guidance from a healthcare provider can help them stay motivated and accountable in their weight loss journey. These resources can offer tips on healthy eating, exercise, and behavior changes that can support long-term weight management. By staying committed to a healthy lifestyle and utilizing the tools and support available, individuals can maintain their weight loss success with semaglutide.

In conclusion, semaglutide has shown promising results in promoting weight loss in individuals struggling with obesity or overweight. Many people have shared their personal experiences of using semaglutide for weight loss, highlighting the positive impact it has had on their health and well-being. While there may be some side effects to consider, the benefits of weight loss with semaglutide are significant for many individuals. By maintaining healthy lifestyle habits and seeking support when needed, individuals can achieve and sustain their weight loss goals with semaglutide.

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In this clip, David Sjostrand, F.N.P. discusses whether you can lose weight effectively by eating less food. David is a Family Nurse Practitioner practicing at West Valley Medical Group. Learn more about David here: https://westvalleymedgroup.com/physicians/profile/David-Sjostrand-FNP

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