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👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)

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If you're anything like me, you have a sweet tooth, and those cravings can make it tough to stick to your diet. Here are a few hacks I use to satisfy those cravings while staying on track: 🎯 Opt for individually wrapped treats. 🎯 Choose low-calorie alternatives like low-calorie jellies and ice cream (my personal go-to). Also, understand that sweet cravings can sometimes signal low chromium levels. Try adding more broccoli and barley into your diet. Comment “SHREDDED GUIDE” to get a copy of the exact meal plan I used to lose 22kg/49lbs while still enjoying my sweet treats!

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Hello Team, are you ready for a very sweaty ALL STANDING HIIT Session? With this 40 Min workout you get sweaty and burn lots of calories with knee friendly exercises. See you on the mat! #fullbodyburn # norepeat *The number of calories you burn will vary from person to person but this might serve as a guideline. ❀Full Body Workout ❀Time: 45 sec on/ 15 sec off ❀Level: High ❀ Don’t forget to Subscribe and turn on notifications so that you don’t miss any Workouts, Community Updates or Surprises: https://www.youtube.com/channel/UC6TSBn2RAx036n04GaN6McA ❀Join the Community: Fitness Channel Instagram: http://instagram.com/eleni.fit__ ❀ My Amazon Storefront: https://www.amazon.de/shop/elenifit ❀ Music: https://www.epidemicsound.com DISCLAIMER If you are new to exercise, you should understand that there is the possibility of physical injury. Please notice that if you performing any exercise or program, you agree that you do so at your own risk. This channel offers health, fitness and nutritional information and is not intended to be a substitute for professional medical advice, diagnosis or treatment.

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この動画では、「オゼンピック皮下注2mg(GLP-1注射薬)」を安全かつ効果的に使用するための基本的な使い方をわかりやすく解説しています。 【目次】 ------------------------------ 00:00 安全にご使用いただくためのご案内 00:04 用意するもの 00:09 注射前に準備すること 00:18 注射針の付け方 00:31 ダイアルの設定 00:42 注射方法 ------------------------------ ✅すでにオゼンピックを処方されている方やご検討されている方で、 「使い方がよくわからない」 「副作用が心配…でも相談できる人がいない」 というお悩みをお持ちの方は、ぜひクリニックフォアの診察にてご相談ください。 ※医学的必要性がないと医師が判断した場合はお薬の処方はできません。 🏥診療実績600万件以上※ クリニックフォアのオンライン診療 クリニックフォアのオンライン肥満症治療は、全国対応で予約から診察、お薬の配送まで全てスマホ1つで完結します。 ※2020年4月〜2025年3月当クリニックのオンライン診療実績(お薬の発送実績込み。発送集約時は集約前の発送回数に転換して計算) 📌オンライン診療の流れ 1 ご予約 スマホ・PCから簡単にご予約可能です。 平日も土日も朝7時から夜24時まで診察しています。※診療時間は祝日など日によって異なる場合がございます。 2 医師の診察 オンラインでも丁寧な診察を心がけています。自宅からでも手軽に受診可能です。 3 自宅への配送 早く治療を開始できるようスピード配送を心がけています。 最短当日発送、翌日お届けいたします。 ※ 決済時間、お届けエリアによります。※医師の判断によりお薬を処方できない場合があります。 ▶クリニックフォアのオンライン肥満症治療はこちら 女性の方向けサイト https://www.clinicfor.life/telemedicine/diet/ 男性の方向けサイト https://www.clinicfor.life/telemedicine/diet-male/ ▶お得なクーポン情報など掲載!クリニックフォアのLINE公式アカウントはこちら https://x.gd/uG2r9 🏥対面での診察も受付中 クリニックフォアはオンライン診療だけでなく、首都圏で10院以上※対面のクリニックを展開しております。内科・皮膚科などの保険診療も含めて幅広く対応。※2025年3月時点 対面のクリニックで診察をご希望の方は下のサイトよりご予約ください ▶クリニックフォアの対面の肥満症治療はこちら 肥満症治療の対面診療 https://www.clinicfor.life/off/diet/ ※保険適用外の自由診療になります。 ※医薬品副作用被害救済制度の対象外となります。 ※効果・効能・副作用の現れ方は個人差がございます。医師の診察をうけ、診断された適切な治療方法をお守りください。 ======================================== オゼンピックは、2型糖尿病の治療薬として厚生労働省に承認されています。肥満治療目的での処方は国内で承認されていません。 ■当クリニックにおける入手経路等 当該医薬品は、国内正規販売代理店(医薬品卸業)から仕入れています。 ■国内の承認医薬品等の有無 オゼンピックと同成分のウゴービが肥満症の治療薬として国内で承認されています。 ■諸外国における安全性等に係る情報 同一成分の注射製剤が日本の厚生労働省とアメリカ食品医薬品局(FDA)で肥満症治療薬として承認されています。(承認年月日:日本2023/03/27、アメリカ2021/06/04 安全性等に関わる情報としては、急性膵炎、低血糖症状(冷や汗、気持ち悪くなる、手足の震え、ふらつく、脱力感)、嘔吐、腹痛、下痢、便秘といった症状が記載されています。 ■医薬品副作用被害救済制度について 万が一重篤な副作用が出た場合は、国の医薬品副作用被害救済制度の対象外となります。 #オゼンピック #GLP1 #オンライン診療 #肥満症治療