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"CBS Mornings" airs weekdays at 7 a.m. on CBS and stream it at 8 a.m. ET on the CBS News app. Subscribe to "CBS Mornings" on YouTube: https://youtube.com/CBSMornings Watch CBS News 24/7: https://cbsnews.com/live/ Download the CBS News app: https://cbsnews.com/mobile/ Follow "CBS Mornings" on Instagram: https://instagram.com/cbsmornings/ Like "CBS Mornings" on Facebook: https://facebook.com/CBSMornings Follow "CBS Mornings" on X: https://twitter.com/CBSMornings Subscribe to our newsletter: https://cbsnews.com/newsletters/ Try Paramount+ free: https://paramountplus.com/?ftag=PPM-05-10aeh8h For video licensing inquiries, contact: [email protected]Lizzo Stuns In Orange Dress For Thanksgiving Amid Weight Loss Ll Wasn The Only Ones Eatinghttp://www.hindawi.com/journals/ije/2014/683515/ A 6 year study of diabetic men with low testosterone. Testosterone therapy resulted in a 38 pound average weight loss and a HgA1C reduction greater than any single diabetic drug on the market. 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You'll also learn how GLP-1 receptor agonists like semaglutide and tirzepatide target brain circuits to support sustainable weight management. ⏱️ Chapter Breakdown: Timestamps 0:00 – Introduction: Why obesity is more than lifestyle 0:54 – The hypothalamic control centre: AgRP vs POMC neurons 1:07 – Leptin resistance and the broken satiety signal 1:49 – The two systems driving Hunger - Homeostatic and Hedonic 3:02 – GLP-1 receptor agonists: how they work on the brain 3:53 – Psychiatric medications and metabolic disruption 🎓 Educational Highlights: – Obesity is regulated by both homeostatic (hypothalamic) and hedonic (reward) systems in the brain – Leptin resistance and ghrelin signalling contribute to persistent hunger – Diets often fail because of neurobiological adaptations that resist sustained weight loss – GLP-1 receptor agonists target brain centres involved in satiety, cravings, and inflammation – Certain psychiatric medications exacerbate metabolic dysfunction—an integrative approach is key – Practical tools for clinicians include layered pharmacological strategies and patient-centred care 👨⚕️ About the Presenter Dr Sanil Rege is a consultant psychiatrist and educator who has trained over 10,000 mental health professionals. 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Originally developed as a treatment for diabetes, this innovative medication has taken on a new role in weight management, proving to be highly effective in reducing hunger and caloric intake. What is Semaglutide? Semaglutide is a medication that mimics the action of the GLP-1 (glucagon-like peptide-1) hormone. This hormone plays a crucial role in appetite control and glucose metabolism. By imitating GLP-1, Semaglutide helps individuals feel fuller for longer periods, reducing the desire to eat and thereby supporting significant weight loss. How Does Semaglutide Work? Semaglutide's primary mechanism is its ability to enhance the body's natural appetite regulation. It interacts with GLP-1 receptors in the brain, which are responsible for controlling hunger and satiety signals. This leads to: Reduced Hunger: Decreases the overall feeling of hunger, making it easier to manage portions and avoid overeating. Lower Caloric Intake: Helps reduce the total number of calories consumed, contributing to weight loss. Improved Blood Sugar Control: Originally designed for diabetes management, Semaglutide also supports stable blood sugar levels, benefiting overall metabolic health. Benefits of Semaglutide: Effective Weight Loss: Clinical trials have shown that Semaglutide can lead to significant weight reduction in individuals struggling with obesity or weight-related health issues. Enhanced Satiety: Increases the feeling of fullness, making it easier to adhere to a calorie-restricted diet. Diabetes Management: Continues to be a vital medication for managing type 2 diabetes by improving blood sugar levels and reducing the risk of complications. Who Can Benefit from Semaglutide? Individuals with obesity or who are overweight and have related health conditions. Patients with type 2 diabetes seeking better glucose control. Anyone looking for a medically supported way to manage their appetite and reduce caloric intake. Important Considerations: Semaglutide is a prescription medication and should be used under the guidance of a healthcare provider. Possible side effects include nausea, vomiting, and gastrointestinal issues, which typically subside over time. It is essential to follow a balanced diet and engage in regular physical activity while taking Semaglutide to maximize its benefits. Conclusion: Semaglutide represents a promising advance in both diabetes management and weight loss. By harnessing the power of the GLP-1 hormone, it offers a dual approach to better health through effective appetite regulation and improved metabolic outcomes. Always consult with a healthcare professional to determine if Semaglutide is the right option for your weight loss journey or diabetes management plan.