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This episode I describe the science of fat loss, including how fat is mobilized and oxidized (burned) and how to increase fat burning by leveraging the nervous system. Most people don't realize it, but our neurons connect to our fat and release epinephrine/adrenaline to facilitate fat oxidation. I explain how this can be accomplished with non-exercise movements such as fidgeting to burn thousands of calories of fat a day-- a practice is rarely discussed but very well supported by the science literature. I also discuss an optimal fat loss protocol using cold to create shiver, and how specific types and timing of exercise impact fat loss. I discuss if exercising fasted indeed increases fat oxidation-- it turns out the type and duration of exercise really matters. And I discuss the use of caffeine, GLP1 from Mate or guayusa and emerging new prescription compounds for fat loss. The episode includes a lot of tools, links to cost-free resources and explanation of the science underlying each tool for fat loss. #HubermanLab #FatLoss #Science Thank you to our sponsors: InsideTracker - http://insidetracker.com/huberman ExpressVPN - http://expressvpn.com/huberman Athletic Greens - http://athleticgreens.com/huberman Cold Protocols via The Cold Plunge: https://thecoldplunge.com/pages/protocols Our Patreon page: https://www.patreon.com/andrewhuberman Supplements from Thorne: http://www.thorne.com/u/huberman Social: Instagram - https://www.instagram.com/hubermanlab Twitter - https://twitter.com/hubermanlab Facebook - https://www.facebook.com/hubermanlab/ Website - https://hubermanlab.com Timestamps: 00:00:00 Introduction 00:06:00 Fat Loss: The Key Role of Neurons 00:08:44 The First Law of Fat Loss 00:11:00 Neurons Connect To Fat! (& That Really Matters) 00:13:38 5 Pillars of Metabolism: Sleep, Essential Fatty Acids, Glutamine, Microbiome, Thyroid 00:19:20 Mindset Truly Matters: Amazing Examples of Beliefs on Fat Loss 00:23:08 Our Brain Talks To Our Fat 00:25:00 The Most Incredible & Dangerous Fat Loss Agent 00:27:28 Losing Fat Is a Two-Part Process: Mobilization and Oxidation 00:32:25 The Critical Role of Adrenaline/Epinephrine, But NOT from Adrenal Glands 00:34:45 Fidgeting & Shivering: A Powerful Science-Supported Method For Fat Loss 00:41:24 How Fidgeting Works: Promotes Epinephrine Release into Fat. “N-E-A-T” 00:44:55 Two Ways of Using Shivering To Accelerate Fat Loss 00:47:30 White, Brown & Beige Fat; & Using Cold-Induced Shiver To Burn Fat 00:50:25 How To Use Cold Properly To Stimulate Fat Loss: Succinate Release Is Key/Shiver 00:52:26 Exact Protocols: (1-5X per week); Don’t Adapt! Submerge and Exit “Sets & Reps” 00:56:15 thecoldplunge.com see “protocols” tab Cold-Shiver-Fat-Loss Tool (cost free) 00:58:03 If Fat-Loss Is Your Goal, Avoid Cold Adaptation: Remember Polar Bear Swimmers 00:58:17 Irisin: Underwhelming; Succinate Is The

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This updates highlights key developments in obesity treatment, focusing on innovative partnerships and trials. Novo Nordisk and United Pharmaceutical have launched a $2 billion GLP-1 triple agonist project, showing promising early results with over 15% weight loss. OPKO Health and Entera Bio are developing a once-daily oral GLP-1 treatment. Zealand Pharma's recent Phase 2b trial for petrelintide reported significant metabolic benefits and weight loss. Raziel Therapeutics is advancing towards a 2027 launch for RZL-012, a fat-dissolving shot effective in reducing targeted fat by up to 34%. Additionally, Novo Nordisk's semaglutide initiative in China aims to manage weight and reduce cardiovascular risks, though rising costs are challenging the accessibility of GLP-1 drugs.

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Advanced HIIT Workout at Home | Extreme Fat Burn & Full Body Conditioning (No Equipment) Take your training to the next level with this Advanced HIIT Workout designed for maximum fat burn and total body strength. This no-equipment, high-intensity routine targets every major muscle group and pushes your endurance to the limit. Perfect for home workouts — no repeats, no excuses! Workout Details: ✅Duration: 15 minutes ✅Style: High Intensity Interval Training (HIIT) ✅Format: No Repeat ✅Equipment: None ✅Level: Advanced What You'll Get: ☑️Increased stamina & endurance ☑️Full-body muscle activation ☑️Maximum calorie burn ☑️Real fat-loss transformation Chapters: ⏱️00:00 to 00:10 – Intro 🔥00:11 to 03:07 – Warm-Up 💪03:08 to 13:15 – HIIT Begins 🧘13:15 to 15:18– Cooldown 👏15:18 to 15:27 – Outro #AdvancedHIIT #HIITWorkoutAtHome #FatBurnWorkout #NoEquipmentWorkout #FullBodyHIIT #HomeWorkout #BodyweightTraining #dynamicphysique

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