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Obesity expert Dr Holly Lofton reviews three alternatives to GLP-1s to help patients drop excess weight. https://www.medscape.com/viewarticle/1000474?src=soc_yt -- TRANSCRIPT -- Hi. I'm Dr Holly Lofton. I'm a board-certified obesity medicine specialist, and I direct the medical weight management program at NYU Langone Health. There is so much information about glucagon-like peptide 1 (GLP-1) agonists as anti-obesity medications. I bet you can't think of a single person who hasn't heard of them, and many of your friends or family members may have even tried them. However, we also have what we call the first generation of medications for weight management, and I'll talk about some of those today. Phentermine. If your patient is not able to tolerate a GLP-1 agonist or is unable to access these medicines for various reasons, one option is phentermine, which has been around for decades. It is an oral medication that's usually taken once a day in the morning. It is a classic appetite suppressant. Phentermine makes people feel less hungry. It also gives people a little more energy, so they're able to increase their activity while creating a caloric deficit, and this leads to weight loss over time. Phentermine differs from the GLP-1 agonists, which are intended for chronic weight management. The FDA has approved phentermine for short-term weight loss; its use is recommended for no more than 12 weeks at a time. The medication comes in doses ranging from 8 mg to 37.5 mg and is usually slowly titrated up depending on tolerance and effect. Side effects that are most often reported include a racing heart, insomnia, agitation, and dry mouth. This drug is not for everyone. Phentermine is contraindicated in those with uncontrolled hypertension, with cardiac disease (such as a history of heart attack), or who are at high risk for heart attack or stroke. Some drug interactions can occur, which should be considered on a case-by-case basis. Phentermine may be an option for your patients if an elevated appetite is keeping them from losing weight. It should be used as an adjunct to lifestyle recommendations, which means eating fewer calories and increasing activity. Phentermine-Topiramate. Another non–GLP-1 agonist medication indicated for obesity is phentermine-topiramate [Qsymia]. This is another oral medication. The idea behind combining these two medications is that they can generate more appetite suppression without the high potential for side effects of phentermine alone, such as agitation, increased heart rate, or increased blood pressure. Topiramate is used for migraine or seizure prevention. One side effect of topiramate is unintentional weight loss, so they decided to combine phentermine with topiramate in one pill. Phentermine-topiramate comes in four different doses and is usually titrated up from the lowest to the highest dose. People who can't tolerate the higher doses of phentermine are able to tolerate Qsymia because the dose of phentermine is lower. This medication came to the market in 2012, after the SEQUEL trial, which demonstrated its safety and efficacy, achieved about 12% weight loss, which for many years was the highest weight loss seen with any other anti-obesity medications on the market. Because this is a combination medication, it has some potential side effects and contraindications. For example, we don't give phentermine-topiramate to people with uncontrolled hypertension or anxiety, and it is contraindicated in those with glaucoma. We don't give this medication to anyone who has had adverse reactions or hypersensitivity to either of the ingredients. Because the combination contains topiramate, it should not be prescribed to anyone with childbearing potential unless they are using an effective form of hormonal contraception or even two effective forms. Topiramate can increase the risk of having a baby with a cleft palate by five times if they become pregnant while taking this medication. Phentermine-topiramate is dosed once daily. One commonly reported side effect is paresthesia: numbness and tingling of the fingers and toes that can manifest as feeling very cold when it's cold outside. Although some patients report paresthesia, most say that it's not so intolerable that they want to discontinue the medication. There have been reports of vision changes in people taking phentermine-topiramate; if severe vision changes occur, it is recommended to discontinue the medication. Transcript in its entirety can be found by clicking here: https://www.medscape.com/viewarticle/1000474?src=soc_yt

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When it comes to weight loss medications, semaglutide has been making waves in the medical world. With the recent approval of oral semaglutide, patients now have the option to choose between the traditional injectable form of the medication and the new oral form. Both versions of semaglutide have been shown to be effective in promoting weight loss, but there are some key differences between the two that patients should be aware of before making a decision. In this article, we will compare oral semaglutide to injectable semaglutide to help you determine which option may be right for you.

Effectiveness of Oral Semaglutide vs. Injectable Semaglutide

Both oral and injectable semaglutide have been shown to be effective in promoting weight loss in patients who are overweight or obese. Injectable semaglutide is typically administered once a week, while oral semaglutide is taken in pill form once a day. Studies have shown that both versions of the medication can lead to significant weight loss when combined with a healthy diet and exercise program.

One study published in the New England Journal of Medicine found that patients who took injectable semaglutide for 68 weeks lost an average of 15% of their body weight, compared to just 2.4% in the placebo group. Another study on oral semaglutide showed similar results, with patients losing an average of 14.9% of their body weight over 68 weeks.

Side Effects of Oral Semaglutide vs. Injectable Semaglutide

Like any medication, both oral and injectable semaglutide can cause side effects in some patients. Common side effects of injectable semaglutide include nausea, diarrhea, and constipation. These side effects are usually mild and tend to subside over time as the body adjusts to the medication.





On the other hand, oral semaglutide may be associated with a higher risk of gastrointestinal side effects, such as nausea and vomiting, compared to the injectable form. However, some patients may prefer the convenience of taking a pill once a day over having to administer a weekly injection.

Cost Comparison of Oral Semaglutide vs. Injectable Semaglutide

Cost is another important factor to consider when choosing between oral and injectable semaglutide. Injectable semaglutide tends to be more expensive than oral semaglutide, both in terms of the medication itself and the cost of supplies needed to administer the injection.

While some insurance plans may cover both forms of semaglutide, patients should check with their provider to see what their out-of-pocket costs will be. In some cases, patients may find that oral semaglutide is a more affordable option, especially if they are not comfortable with administering injections themselves.

Convenience and Accessibility of Oral Semaglutide vs. Injectable Semaglutide

When it comes to convenience, oral semaglutide may have the upper hand. Taking a pill once a day is generally easier for patients than having to remember to administer a weekly injection. Oral semaglutide can also be taken without any special training, whereas injectable semaglutide requires patients to learn how to properly administer the injection.

Accessibility is another factor to consider. While injectable semaglutide may require a prescription and a visit to the doctor’s office to receive the injection, oral semaglutide can be picked up at a pharmacy without the need for a doctor’s visit. This may make oral semaglutide a more attractive option for some patients.

Long-Term Success Rates of Oral Semaglutide vs. Injectable Semaglutide

Long-term success rates of oral and injectable semaglutide have not been well-studied, as both medications are relatively new to the market. However, initial studies have shown promising results for both forms of the medication.

Patients who are able to stick to a healthy diet and exercise program while taking semaglutide are likely to see long-term benefits in terms of weight loss and overall health. It is important for patients to work closely with their healthcare provider to monitor their progress and make any necessary adjustments to their treatment plan.

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Semaglutide is a medication that has gained popularity for its effectiveness in helping individuals achieve weight loss. Originally approved for the treatment of type 2 diabetes, semaglutide has shown promising results in promoting weight loss when used at higher doses. While the injectable form of semaglutide has been the primary method of administration for weight loss, a new oral formulation has been developed as a more convenient option for patients. In this article, we will explore the pros and cons of semaglutide oral vs injection for weight loss.

Effectiveness

Semaglutide has been shown to be highly effective in promoting weight loss in individuals who are overweight or obese. Clinical trials have demonstrated that patients using semaglutide have achieved significant weight loss compared to those using a placebo. The injectable form of semaglutide has been more extensively studied and has been shown to produce greater weight loss results compared to the oral formulation. However, the oral form of semaglutide is still considered to be effective in helping individuals reach their weight loss goals.

Convenience

One of the primary advantages of the oral form of semaglutide is its convenience. Unlike the injectable form, which requires administration via a needle, the oral formulation can be taken simply by swallowing a pill. This may make it a more attractive option for individuals who are averse to needles or who have difficulty with injections. Additionally, the oral form of semaglutide may be more convenient for those who travel frequently or have busy schedules, as it can be taken without the need for refrigeration or special storage.

Adherence

Adherence to medication regimens is crucial for achieving successful weight loss results. Some individuals may find it more challenging to adhere to a medication that requires regular injections, as opposed to one that can be taken orally. The convenience of the oral form of semaglutide may help improve adherence rates among patients, leading to better outcomes in terms of weight loss. However, it is important to note that adherence is a personal factor that can vary among individuals, and some patients may still prefer the injectable form despite the convenience of the oral option.

Side Effects

Both the injectable and oral forms of semaglutide can cause side effects, though these are typically mild and temporary. Common side effects may include nausea, diarrhea, and constipation. Some individuals may experience injection site reactions with the injectable form of semaglutide. The oral form of semaglutide may be associated with a higher risk of gastrointestinal side effects due to its route of administration. Patients should discuss potential side effects with their healthcare provider before starting semaglutide for weight loss.

Cost

Cost may be a significant factor for individuals considering semaglutide for weight loss. The injectable form of semaglutide can be more expensive than the oral formulation, as it typically requires more frequent dosing. Insurance coverage may vary for these different forms of semaglutide, so patients should check with their provider to determine coverage and out-of-pocket costs. Cost considerations may influence a patient’s decision between the injectable and oral forms of semaglutide for weight loss.

In conclusion, both the oral and injectable forms of semaglutide have their own set of pros and cons when it comes to weight loss. The choice between the two will ultimately depend on individual preferences, lifestyle factors, and healthcare provider recommendations. Patients should discuss the options with their healthcare provider to determine the most suitable form of semaglutide for their weight loss goals.

FAQ

Q: Is semaglutide safe for weight loss?

A: Semaglutide has been shown to be safe and effective for weight loss in clinical trials. However, like any medication, it may cause side effects in some individuals. It is important to discuss any concerns with your healthcare provider before starting semaglutide for weight loss.





Q: How long does it take to see results with semaglutide for weight loss?

A: Results with semaglutide can vary among individuals, but many patients start to see weight loss within the first few weeks of treatment. It is important to follow a healthy diet and exercise regimen in conjunction with taking semaglutide to maximize results.

Q: Can semaglutide be used long-term for weight loss?

A: Semaglutide is typically used for a prescribed period of time to help individuals achieve weight loss goals. Your healthcare provider will determine the appropriate duration of treatment based on your individual needs. It is important to follow up with your provider regularly while taking semaglutide for weight loss.

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In addition to supporting ketosis and fat burning, Keto Excel can also help improve your energy levels and mental clarity. By providing your body with a steady source of ketones and MCTs, this supplement can help fuel your brain and muscles for sustained energy throughout the day.

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Moreover, the electrolytes in Keto Excel can help prevent fatigue and muscle cramps, allowing you to stay active and focused on your daily tasks. Whether you’re working out at the gym or tackling a busy workday, this supplement can help you stay energized and alert without the jitters or crashes associated with traditional energy-boosting products.

With Keto Excel, you can experience increased mental clarity, improved focus, and enhanced performance in all areas of your life. Say goodbye to brain fog and fatigue – and hello to a sharper mind and stronger body with this powerful ketosis-supporting supplement.

Support Overall Health and Well-Being

Lastly, Keto Excel is not just about helping you excel in ketosis – it’s also about supporting your overall health and well-being. This supplement is packed with antioxidants and other beneficial compounds that can help protect your cells from damage, reduce inflammation, and support your immune system.

By incorporating Keto Excel into your daily routine, you can give your body the nutrients it needs to function optimally and thrive on a ketogenic diet. From improved digestion and gut health to enhanced detoxification and antioxidant protection, this supplement offers a wide range of benefits for your long-term health and vitality.

Don’t settle for mediocre results on your ketogenic diet journey. With Keto Excel, you can take your ketosis efforts to the next level and achieve lasting success in reaching your health and fitness goals. Try it today and see the difference it can make in your energy levels, fat burning capabilities, and overall well-being.

Whether you’re a seasoned keto veteran or just starting out, Keto Excel can help you excel in ketosis and experience the many benefits of this powerful dietary approach. Take your health and wellness to new heights with this comprehensive supplement and see what a difference it can make in your ketogenic journey.

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GoKeto Gummies is the high level dietary enhancement intended to advance weight reduction and accomplish the sound condition of ketosis. It is the recipe including the sound and strong mix of spices and clinically supported substances that uplifts the ketone levels in body to actuate the ketosis cycle. It is has the full range BHB salt that works related to different substances to set off ketosis and carry your body to the solid condition of ketosis where it can consume off the fat cells rapidly and accomplish the ideal weight reduction result. The enhancement is clinically supported to carry the body to the solid condition of ketosis where it can consume off the fat cells rapidly and productively. Click here for more Information- https://groups.google.com/g/goketo-gummies-full-details/c/FcpRJrFsNlM

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BiolyfeKeto Gummies are not your average gummy supplement. Each gummy is packed with a potent combination of BHB (beta-hydroxybutyrate) salts, MCT oil, and other key nutrients that work together to enhance your ketosis experience. By providing your body with a steady source of ketones, BiolyfeKeto Gummies can help you reach and maintain a state of ketosis more effectively, leading to increased energy levels, improved mental clarity, and faster weight loss results.

Unlike other keto supplements on the market, BiolyfeKeto Gummies are made with all-natural ingredients that are free from artificial colors, flavors, and preservatives. You can feel good about incorporating these gummies into your daily routine, knowing that you are supporting your body with clean, high-quality nutrition. Plus, the delicious mixed berry flavor makes them a joy to take, so you’ll actually look forward to supplement time!

How BiolyfeKeto Gummies Work

When you follow a ketogenic diet, your body transitions from using glucose as its primary fuel source to using fat instead. This metabolic state is known as ketosis, and it can be challenging to achieve and maintain without the right support. BiolyfeKeto Gummies work by providing your body with a source of exogenous ketones, which can help jumpstart ketosis and keep you in fat-burning mode. By taking just a few gummies each day, you can amplify the benefits of your keto diet and see results faster than ever before.

In addition to promoting ketosis, BiolyfeKeto Gummies also help to curb cravings and reduce the symptoms of the “keto flu.” Many people experience sugar cravings and fatigue when they first start a ketogenic diet, but these gummies can help to alleviate those side effects and make the transition to ketosis smoother and more enjoyable. With BiolyfeKeto Gummies, you can feel confident and in control of your keto journey.

Experience the BiolyfeKeto Difference

Don’t settle for mediocre results on your keto journey – elevate your experience with BiolyfeKeto Gummies! With their powerful blend of keto-friendly ingredients, delicious flavor, and convenient gummy form, these supplements are the perfect addition to any ketogenic lifestyle. Whether you’re new to keto or a seasoned pro, BiolyfeKeto Gummies can help you achieve your goals and feel your best every day. Try them today and see the difference for yourself!

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Ready to take your keto experience to the next level? Try BiolyfeKeto Gummies today and see the difference for yourself. With their potent blend of BHB salts, MCT oil, and other key nutrients, these gummies can help you reach and maintain ketosis more effectively, leading to increased energy levels, improved mental clarity, and faster weight loss results. Don’t settle for mediocre results – elevate your keto journey with BiolyfeKeto Gummies!

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