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Learn more at Penn Medical Group: https://pennmedicalgroup.com/ or call us at (610) 321-7777 for a free consultation. GLP-1 (glucagon-like peptide-1) agonists are a class of medications primarily developed for the treatment of type 2 diabetes. They mimic the function of the body's natural GLP-1 hormone, which is involved in glucose regulation and appetite control. Here's how GLP-1 agonists work and why they're of interest for weight loss: Stimulation of Insulin Secretion: When glucose levels rise after eating, GLP-1 stimulates the pancreas to release insulin, which helps cells absorb glucose from the bloodstream. Decrease in Glucagon Release: GLP-1 reduces the release of glucagon, a hormone that raises blood sugar levels by stimulating the liver to release stored glucose. Appetite Regulation: GLP-1 is also produced in the intestines and plays a role in signaling the brain to induce feelings of fullness or satiety. This decreases appetite and leads to reduced food intake. Gastric Emptying Delay: GLP-1 agonists can slow the rate at which the stomach empties after eating, leading to a slower rise in blood glucose and a prolonged feeling of fullness. Given these effects, especially the appetite-suppressing quality, GLP-1 agonists have been studied for their potential in weight loss, even in individuals without diabetes. Clinical studies have shown that some people taking GLP-1 agonists lost significant amounts of weight in comparison to those not on the medication. Examples of GLP-1 agonists include: - Liraglutide (brand name: Victoza for diabetes and Saxenda for weight loss) - Exenatide (brand names: Byetta, Bydureon) - Dulaglutide (brand name: Trulicity) - Semaglutide (brand name: Ozempic for diabetes and Wegovy for weight loss) It's important to consult with a healthcare professional before starting any weight loss medication. They can provide insights into potential side effects, interactions with other medications, and guidance on appropriate use.

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