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‎परिचय: ‎Sitagliptin एक मौखिक (oral) दवा है जिसका उपयोग टाइप 2 डायबिटीज मेलिटस (Type 2 Diabetes Mellitus) के इलाज के लिए किया जाता है। यह दवा रक्त में शुगर (ग्लूकोज) के स्तर को नियंत्रित करने में मदद करती है और आमतौर पर अन्य एंटी-डायबिटिक दवाओं के साथ प्रयोग की जाती है। यह दवा डायबिटीज के कारण होने वाली जटिलताओं को कम करने में सहायक होती है। ‎ ‎1. Sitagliptin क्या है? ‎Sitagliptin एक DPP-4 (Dipeptidyl Peptidase-4) इनहिबिटर है। यह शरीर में हार्मोन GLP-1 (Glucagon-like Peptide-1) और GIP (Glucose-dependent Insulinotropic Peptide) के स्तर को बढ़ाकर इंसुलिन की मात्रा बढ़ाने और ग्लूकागन (Glucagon) के स्तर को कम करने में मदद करता है। इससे भोजन के बाद ब्लड शुगर का स्तर नियंत्रित रहता है। ‎ ‎2. Sitagliptin का उपयोग ‎Sitagliptin मुख्य रूप से टाइप 2 डायबिटीज के इलाज में निम्नलिखित उद्देश्यों के लिए उपयोग की जाती है: ‎ब्लड शुगर को नियंत्रित करना: यह शरीर में इंसुलिन के उत्पादन को बढ़ाने और लीवर द्वारा बनने वाले ग्लूकोज की मात्रा को कम करने में मदद करता है। ‎ ‎मोनोथेरेपी या संयोजन थेरेपी: इसे अकेले या अन्य एंटी-डायबिटिक दवाओं जैसे मेटफॉर्मिन, सल्फोनाइल यूरिया, या इंसुलिन के साथ प्रयोग किया जा सकता है। ‎वजन बढ़ने का कम जोखिम: अन्य एंटी-डायबिटिक दवाओं की तुलना में Sitagliptin के कारण वजन बढ़ने की संभावना कम होती है। ‎ ‎हाइपोग्लाइसीमिया (कम ब्लड शुगर) का कम जोखिम: यह दवा ब्लड शुगर को नियंत्रित करने में सहायक होती है, लेकिन अन्य दवाओं की तुलना में हाइपोग्लाइसीमिया का जोखिम कम होता है। ‎ ‎3. Sitagliptin की खुराक और सेवन का तरीका ‎Sitagliptin की सामान्य खुराक 25mg, 50mg, और 100mg की टैबलेट के रूप में उपलब्ध होती है। ‎ ‎सामान्य खुराक: ‎ ‎100mg दिन में एक बार (डॉक्टर की सलाह अनुसार) ‎किडनी की समस्या वाले मरीजों के लिए कम खुराक (25mg या 50mg) दी जाती है। ‎ ‎कैसे लें? ‎ ‎इसे भोजन के साथ या बिना भोजन के लिया जा सकता है। ‎ ‎इसे रोज़ एक ही समय पर लेना बेहतर होता है ताकि इसका प्रभाव बना रहे। ‎ ‎खुराक छूट जाने पर: ‎ ‎यदि कोई खुराक छूट जाए तो जैसे ही याद आए, ले लें। ‎ ‎यदि अगली खुराक का समय हो गया हो तो मिस की गई खुराक को छोड़ दें और नियमित समय पर अगली खुराक लें। ‎ ‎4. Sitagliptin के संभावित साइड इफेक्ट्स ‎ ‎हालांकि Sitagliptin आमतौर पर सुरक्षित मानी जाती है, लेकिन इसके कुछ साइड इफेक्ट्स हो सकते हैं: ‎ ‎आम साइड इफेक्ट्स: ‎ ‎सिरदर्द ‎ ‎जी मिचलाना ‎ ‎पेट में हल्का दर्द ‎ ‎डायरिया ‎ ‎ऊपरी श्वसन संक्रमण (सर्दी-जुकाम जैसे लक्षण) ‎ ‎गंभीर साइड इफेक्ट्स: ‎ ‎पैंक्रियाटाइटिस: (अग्न्याशय में सूजन) - यदि पेट के ऊपरी हिस्से में तेज दर्द हो, उल्टी आए, तो तुरंत डॉक्टर से संपर्क करें। ‎ ‎गुर्दे की समस्या: यदि पेशाब कम हो रहा हो या पैरों में सूजन आ रही हो तो डॉक्टर को बताएं। ‎ ‎एलर्जी प्रतिक्रिया: खुजली, सूजन, साँस लेने में तकलीफ जैसी एलर्जी हो सकती है। ‎ ‎जोड़ों में दर्द: कुछ मरीजों को गंभीर जोड़ों का दर्द हो सकता है। ‎ ‎ब्लड शुगर में अत्यधिक कमी (Hypoglycemia): यदि यह दवा अन्य ब्लड शुगर कम करने वाली दवाओं (जैसे इंसुलिन या सल्फोनाइल यूरिया) के साथ ली जाती है तो हाइपोग्लाइसीमिया हो सकता है। ‎ ‎5. किन लोगों को सावधानी बरतनी चाहिए? ‎ ‎निम्नलिखित परिस्थितियों में Sitagliptin का सेवन करने से पहले डॉक्टर से परामर्श लेना आवश्यक है: ‎ ‎किडनी की समस्या: कमजोर किडनी वाले मरीजों के लिए खुराक कम करनी पड़ सकती है। ‎ ‎लीवर की बीमारी: लिवर की समस्या होने पर डॉक्टर की सलाह के बिना न लें। ‎ ‎गर्भवती या स्तनपान कराने वाली महिलाएं: इस दवा के सुरक्षित होने को लेकर पर्याप्त शोध नहीं हैं, इसलिए डॉक्टर की सलाह लें। ‎ ‎टाइप 1 डायबिटीज: यह दवा केवल टाइप 2 डायबिटीज के लिए उपयोगी है। ‎ ‎पैंक्रियाटाइटिस का इतिहास: यदि पहले से अग्नाशय में सूजन रही हो तो Sitagliptin से बचना चाहिए। ‎ ‎6. Sitagliptin किन दवाओं के साथ इंटरैक्ट कर सकती है? ‎ ‎कुछ दवाओं के साथ Sitagliptin की प्रतिक्रिया हो सकती है, इसलिए यदि आप निम्नलिखित दवाएं ले रहे हैं तो डॉक्टर को सूचित करें: ‎ ‎इंसुलिन या अन्य ब्लड शुगर कम करने वाली दवाएं: हाइपोग्लाइसीमिया का खतरा बढ़ सकता है। ‎ ‎डायगॉक्सिन: हृदय से संबंधित इस दवा के साथ सावधानी बरतें। ‎ ‎स्ट्रॉन्ग एंटीबायोटिक्स: कुछ एंटीबायोटिक्स इसके प्रभाव को बढ़ा या घटा सकते हैं। ‎ ‎कोर्टिकोस्टेरॉइड्स: ये दवाएं ब्लड शुगर को बढ़ा सकती हैं, जिससे Sitagliptin का प्रभाव कम हो सकता है। ‎ ‎ ‎Sitagliptin टाइप 2 डायबिटीज के इलाज में प्रभावी और सुरक्षित दवा है। यह शरीर में ब्लड शुगर को नियंत्रित करने, हाइपोग्लाइसीमिया का जोखिम कम करने और वजन बढ़ने से बचाने में मदद करती है। हालांकि, इसे लेने #sitagliptin #Januvia #zita100 #sitasmaet

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