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Inhibitors of dipeptidyl peptidase 4 (DPP-4 inhibitors or gliptins) are a class of oral hypoglycemics that block the enzyme dipeptidyl peptidase-4 (DPP-4). They can be used to treat diabetes mellitus type 2. The first agent of the class – sitagliptin – was approved by the FDA in 2006.[1] Glucagon increases blood glucose levels, and DPP-4 inhibitors reduce glucagon and blood glucose levels. The mechanism of DPP-4 inhibitors is to increase incretin levels (GLP-1 and GIP),[2][3][4] which inhibit glucagon release, which in turn increases insulin secretion, decreases gastric emptying, and decreases blood glucose levels. A 2018 meta-analysis found no favorable effect of DPP-4 inhibitors on all-cause mortality, cardiovascular mortality, myocardial infarction or stroke in patients with type 2 diabetes.[5] ExamplesEdit Drugs belonging to this class are: Sitagliptin[6] (FDA approved 2006, marketed by Merck & Co. as Januvia) Vildagliptin[7] (EU approved 2007, marketed in the EU by Novartis as Galvus) Saxagliptin (FDA approved in 2009, marketed as Onglyza) Linagliptin (FDA approved in 2011, marketed as Tradjenta by Eli Lilly and Company and Boehringer Ingelheim)[8] Gemigliptin (approved in Korea in 2012, marketed by LG Life Sciences)[9] Marketed as Zemiglo Anagliptin (approved in Japan in 2012, marketed by Sanwa Kagaku Kenkyusho Co., Ltd. and Kowa Company, Ltd.)[10] Teneligliptin (approved in Japan in 2012[11]) Alogliptin (FDA approved 2013, marketed by Takeda Pharmaceutical Company) Trelagliptin (approved for use in Japan in 2015) Omarigliptin (MK-3102) (approved in Japan in 2015,[12] developed by Merck & Co.; research showed that omarigliptin can be used as once-weekly treatment and generally well-tolerated throughout the base and extension studies[13]) Evogliptin (approved for use in South Korea[14]) Gosogliptin (approved for use in Russia[15]) Dutogliptin (being developed by Phenomix Corporation), Phase III[16] Other chemicals which may inhibit DPP-4 include: Berberine, an alkaloid found in plants of the genus Berberis, inhibits dipeptidyl peptidase-4 which may at least partly explains its antihyperglycemic activity.[17] Adverse effectsEdit In those taking sulphonylureas, there is an increased risk of low blood sugar.[18] Adverse effects, including nasopharyngitis, headache, nausea, heart failure, hypersensitivity and skin reactions. The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines like sitagliptin, saxagliptin, linagliptin, and alogliptin may cause joint pain that can be severe and disabling. FDA has added a new Warning and Precaution about this risk to the labels of all medicines in this drug class, called dipeptidyl peptidase-4 (DPP-4) inhibitors.[19] However, studies assessing risk of rheumatoid arthritis among DPP-4 inhibitor users have been inconclusive.[20] A 2014 review found increased risk of heart failure with saxagliptin and alogliptin, prompting the FDA in 2016 to add warnings to the relevant drug labels.[21] A 2018 meta analysis showed that use of DPP-4 inhibitors was associated with a 58% increased risk of developing acute pancreatitis compared with placebo or no treatment.[22] A 2018 observational study suggested an elevated risk of developing inflammatory bowel disease (specifically, ulcerative colitis), reaching a peak after three to four years of use and decreasing after more than four years of use.[23] CancerEdit In response to a report of precancerous changes in the pancreases of rats and organ donors treated with the DPP-4 inhibitor sitagliptin,[24][25] the United States FDA and the European Medicines Agency each undertook independent reviews of all clinical and preclinical data related to the possible association of DPP-4 inhibitors with pancreatic cancer. In a joint letter to the New England Journal of Medicine, the agencies stated that they had not yet reached a final conclusion regarding a possible causative relationship.[26] A 2014 meta-analysis found no evidence for increased pancreatic cancer risk in people treated with DPP-4 inhibitors, but owing to the modest amount of data available, was not able to completely exclude possible risk.[27] Combination drugsEdit Some of the DPP-4 inhibitor drugs have gotten approval from the FDA to be used with metformin concomitantly with additive effect to increase the level of glucagon-like peptide 1 (GLP-1) which also decreases hepatic glucose production.[28]

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http://www.iHealthTube.com Dr. Harry Preuss explains how people can lose fat by gaining muscle, even though the scale doesn't reflect a big weight change. An educational video exlcusive on iHealthTube.

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For weekly health research summaries and extra insights, sign up here 👉 https://drstanfield.com/pages/sign-up 💊 Supplements I Take: https://drstanfield.com/pages/my-supplements 💊 MicroVitamin (multivitamin & mineral that I take): https://drstanfield.com/products/microvitamin 📜 Roadmap - how to look young & feel strong: https://drstanfield.com/pages/roadmap ✔️ Twitter: https://twitter.com/BradStanfieldMD ✔️ Patreon: https://www.patreon.com/bradstanfieldmd Here are the links to the research papers referenced in the video: https://pmc.ncbi.nlm.nih.gov/articles/PMC8243436/ https://www.jstage.jst.go.jp/article/bbb/73/8/73_90231/_article https://www.uptodate.com/contents/obesity-in-adults-dietary-therapy https://pubmed.ncbi.nlm.nih.gov/21105792/ https://pmc.ncbi.nlm.nih.gov/articles/PMC9729142/ https://www.liebertpub.com/doi/10.1089/met.2010.0031 https://pmc.ncbi.nlm.nih.gov/articles/PMC9105806/ https://pmc.ncbi.nlm.nih.gov/articles/PMC6723598/ https://bmjopen.bmj.com/content/5/8/e008222.long https://www.sciencedirect.com/science/article/pii/S2667036423000018 https://dom-pubs.onlinelibrary.wiley.com/doi/abs/10.1111/dom.15501 Thumbnail by James Kelly Video edited by Troy Young Script by John Milliken The links above are affiliate links, so I receive a small commission every time you use them to purchase a product. The content contained in this video, and its accompanying description, is not intended to replace viewers’ relationships with their own medical practitioner. Always speak with your doctor regarding the content of this channel, and especially before using any products, services, or devices discussed on this channel.

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Dr. DeVincentis, or Dr. D. as his patients call him, uses non-invasive technology through a procedure called i-Lipo.

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Recuerda: La clave no es perder peso … lo importante es sanar y para sanar debes entender la causas de tu aumento de peso 🔥 No estoy diciendo que esos medicamentos sean malos ❌ solo invito a un uso responsable teniendo en cuenta factores como el que menciono en el video 🙏🏻 Ref. Karakasis P, Patoulias D, Fragakis N, Mantzoros CS. Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition: Systematic review and network meta-analysis. Metabolism. 2024 Dec 22;164:156113. doi: 10.1016/j.metabol.2024.156113. Epub ahead of print. PMID: 39719170. No comas cuento, aprende a comer real convirtiéndote en miembro de esta comunidad 👇🏻 📲 Mis Redes Sociales 🔴 https://www.facebook.com/DrOscarRosero 🔴 https://www.instagram.com/endocrinorosero #ozempic #endocrinorosero #shorts

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Simak dalam good talk live hari ini dengan narasumber Dr.dr. Hans Tandra, Sp.PD-KEMD, Ph.D, FINASIM, FACE, FACP. Beliau adalah internist, endokrinologist, dan health motivator. Pertanyaan bisa ditulis di comment IG Live dan Live chat pada youtube. Sebutkan usia, berat badan dan tinggi badan untuk jawaban lebih akurat sesuai keluhan. Jika ingin identitas dirahasiakan, bisa DM di goodtalk.id Follow instagram @goodtalk.id untuk mendapatkan tips sehat dari kami. Salam sehat

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So do they work? Well medical experts and pharmacists say no, and it has to be said if weight loss came in a bottle the whole world would be slim. To date no herbal preparations have been conclusively shown in trials to be both safe and effective for long-term weight loss. Just because it's natural doesn't mean it's safe, and you're far better off sticking to a healthy diet and taking exercise. How to deal with a sexually harrassing boss? We all dread it happening to us -- we get an awful boss that we just can't live with. It's no wonder that Warner Brothers made the Hollywood movie, Horrible Bosses. In the movie, Jennifer Aniston plays an out-of-control sexual predator who's set her sights on her assistant and won't take no for an answer. And although this leads to a number of funny scenes in the film, in real life sexual harassment is a very serious issue that can be difficult for employees to talk about. Sexual harassment can be anything that's sexual in nature which makes you uncomfortable. It could be something as innocuous as a colleague asking if you had sex over the weekend, to your boss patting you on the bum as you walk by his desk. But what do you do if it happens to you? The best advice is to start keeping a journal. Write down what happened, what was said to you, and how you chose to deal with it at the time. Put the date and the time of the incident. Keep the journal in a safe place, preferably at home. Next, tell someone. Start with your Human Resources department. If you work for a small company and there is no HR department then talk to your boss's boss. Remember, you have done nothing wrong. In the UK, you have a legal right under the Sex Discrimination Act not to be sexually harassed by your boss or colleagues. This covers things like comments about the way you look that you find demeaning, indecent remarks, questions about your sex life, sexual discrimination and sexual demands. If you're experiencing this you may feel there is no alternative but to leave your job. If you don't have anyone you can talk to, you can get free advice from the Advisory, Conciliation and Arbitration Service (ACAS). You may be thinking you need this job. No you don't. No job is worth sticking with if you're being sexually harassed. It's not worth your health, it's not worth your time, and it certainly isn't worth any amount of money. Hand in your notice and file for unfair dismissal. It's that simple.

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