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Click Here to Subscribe: http://Bit.ly/ThomasVid Get MY Groceries at MY Price with Thrive Market: http://ThriveMarket.com/Thomas My Website: http://ThomasDeLauer.com Snacking vs. Fat Loss | The Dangers of Snacking Between Meals | Insulin Spiking- Thomas DeLauer… Snacking - Insulin & Glucagon: Whenever you eat food, your pancreas releases insulin into the blood - as the nutrients are slowly absorbed into cells, insulin levels drop, until finally all the nutrients are absorbed, and insulin levels then remain steady at a low, “baseline” level. So, when you're constantly eating, you're consistently releasing insulin, which puts your body into its "absorptive phase." This means that the insulin in your body is storing sugar and not letting other enzymes in your body release sugar to break down fat. Glucagon: Insulin, the fat-storage and blocking hormone, has a counterpart known as glucagon – a fat-burning and unlocking hormone. About four to six hours after you eat, the glucose levels in your blood decrease, triggering your pancreas to produce glucagon. This hormone signals your liver and muscle cells to change the stored glycogen back into glucose. Glucagon signals the fat cells to release free fatty acids (a process called lipolysis), which signals the body to release stored fat to be used as fuel. Snacking & Digestion: Snacking can affect digestive function as it may increase risk for developing bacterial overgrowth. When bacteria replicate excessively in the small intestine, it results in a condition called Small Intestinal Bacterial Overgrowth. When the body is fasted, the muscles in the small intestine produce a periodic wave of forward motion called the migrating motor complex. The migrating motor complex is a distinct pattern of electromechanical activity observed in gastrointestinal smooth muscle during the periods between meals. It is thought to serve a "housekeeping" role and sweep residual undigested material through the digestive tube. The intestines need to be fasted for at least 90 minutes at a time in order for routine cleansing waves to occur. An increase in gastric, biliary and pancreatic secretion is also seen in conjunction with the motor activity. These secretions aid in the cleansing activity of the migrating motor complex and assist in preventing a buildup of bacterial populations in the proximal segments of the digestive tube. Study - 2 Meals vs 6 Meals per Day: Published in the journal Diabetologica, researchers found that eating 2 larger meals a day (breakfast and lunch) is more effective than 6 smaller meals in a reduced-energy regimen (for patients with type 2 diabetes.) The study compared the effect of six (A6 regimen) vs two meals a day, breakfast and lunch (B2 regimen), on body weight, hepatic fat content (HFC), insulin resistance and beta cell function. Design: Researchers assigned 54 patients with type 2 diabetes, both men and women, age 30–70 years, to follow two regimens of a hypoenergetic diet (below normal, caloric restriction), A6 and B2, each for 12 weeks. The diet in both regimens had the same macronutrient and energy content. Results: Body weight decreased in both regimens, more for B2 (-5.07 lbs for A6 vs −8.1 lbs for B2) HFC decreased in response to both regimens, more for B2 (−0.03% for A6 vs −0.04% for B2) Fasting plasma glucose and C-peptide levels decreased in both regimens, more for B2 Fasting plasma glucagon decreased with the B2 regimen, whereas it increased for the A6 regimen OGIS (oral glucose insulin sensitivity) increased in both regimens, more for B2 - No adverse events were observed for either regimen. Conclusion: Eating only breakfast and lunch reduced body weight, HFC, fasting plasma glucose, C-peptide and glucagon, and increased OGIS, more than the same caloric restriction split into six meals. References: 1) How Insulin Really Works: It Causes Fat Storage...But Doesn't Make You Fat | Muscle For Life. (n.d.). Retrieved from https://www.muscleforlife.com/how-insulin-works/ 2) Understanding Our Bodies: Insulin | Nutrition Wonderland. (n.d.). Retrieved from http://nutritionwonderland.com/2010/05/understanding-our-bodies-insulin/ 3) Insulin and Glucagon: How Do They Work? (n.d.). Retrieved from http://www.healthline.com/health/diabetes/insulin-and-glucagon#Workingtogether2 4) Unlock Glucagon: Your Body's Fat-Burning Hormone. (n.d.). Retrieved from http://healinggourmet.com/weight-loss-diet/unlock-glucagon-fat-burning-hormone/ 5) The effect of meal frequency in a reduced-energy regimen on the gastrointestinal and appetite hormones in patients with type 2 diabetes: A randomised crossover study. (n.d.). Retrieved from http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0174820 6) The Migrating Motor Complex. (n.d.). Retrieved from http://www.vivo.colostate.edu/hbooks/pathphys/digestion/stomach/mmcomplex.html

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In this journal club episode, my guest is Stanford and Johns Hopkins-trained physician, Dr. Peter Attia, M.D., who is also the host of The Drive podcast and the author of the bestselling book "Outlive: The Science & Art of Longevity." We each present a scientific paper and discuss the findings' strengths, weaknesses and actionable takeaways. First, we discuss an article that addresses whether taking the drug metformin can enhance longevity. Then, we discuss an article on belief effects (similar to placebo effects), showing how the effects of a drug on the brain and cognition depend on one's belief about the dose of the drug taken, not the actual dose. Our conversation also highlights how to read, interpret and critique scientific studies. This episode ought to be of interest to those curious about health and longevity, medicine and psychology and for anyone seeking to better understand how to read and digest scientific findings. #HubermanLab #Science Thank you to our sponsors AG1: https://drinkag1.com/huberman Helix Sleep: https://helixsleep.com/huberman Levels: https://levels.link/huberman InsideTracker: https://insidetracker.com/huberman Momentous: https://livemomentous.com/huberman Huberman Lab Social & Website Instagram: https://www.instagram.com/hubermanlab Threads: https://www.threads.net/@hubermanlab Twitter: https://twitter.com/hubermanlab Facebook: https://www.facebook.com/hubermanlab TikTok: https://www.tiktok.com/@hubermanlab LinkedIn: https://www.linkedin.com/in/andrew-huberman Website: https://hubermanlab.com Newsletter: https://hubermanlab.com/neural-network Dr. Peter Attia Website: https://peterattiamd.com Outlive: The Science & Art of Longevity: https://peterattiamd.com/outlive The Peter Attia Drive Podcast: https://peterattiamd.com/podcast Newsletter: https://peterattiamd.com/newsletter X (formerly Twitter): https://twitter.com/PeterAttiaMD Instagram: https://www.instagram.com/peterattiamd YouTube: https://www.youtube.com/c/PeterAttiaMD Facebook: https://www.facebook.com/peterattiamd Articles Reassessing the evidence of a survival advantage in Type 2 diabetes treated with metformin compared with controls without diabetes: a retrospective cohort study: https://bit.ly/3EypTAJ The Hallmarks of Aging: https://bit.ly/3ZeqnFI Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls: https://bit.ly/3Lespjp A thalamic circuit represents dose-like responses induced by nicotine-related beliefs in human smokers: https://bit.ly/3LiAaEX Other Resources TAME (Targeting Aging with Metformin) Trial: https://bit.ly/3P7eMDI Interventions Testing Program (ITP): https://bit.ly/3EDtmOg Slow-Carb Diet (Tim Ferris): https://bit.ly/462q6YD Dr. Alia Crum: Science of Mindsets for Health & Performance (Huberman Lab episode): https://bit.ly/3PdbKhd Nicotine’s Effects on the Brain & Body & How to Quit Smoking or Vaping (Huberman Lab episode): https://bit.ly/3PkGopc Adderall, Stimulants & Modafinil for ADHD: Short- & Long-Term Effects (Huberman Lab episode): https://bit.ly/3Pg7jT3 Neural correlates of interspecies perspective taking in the post-mortem Atlantic Salmon: an argument for multiple comparisons correction (Dead salmon study): https://bit.ly/3PvJvf9 Timestamps 00:00:00 Dr. Peter Attia, Journal Club 00:03:27 Sponsors: Helix Sleep & Levels 00:06:11 Dreams 00:12:36 Article #1, Metformin, Mitochondria, Blood Glucose 00:19:47 Type 2 Diabetes & Causes, Insulin Resistance 00:25:30 Type 2 Diabetes Medications, Metformin, Geroprotection, Bannister Study 00:36:19 Sponsor: AG1 00:37:15 TAME Trial; Demographics, Twin Cohort 00:44:27 Metformin & Mortality Rate 00:51:28 Kaplan-Meier Mortality Curve, Error Bars & Significance, Statistical Power 01:01:17 Sponsor: InsideTracker 01:02:23 Hazard Ratios, Censoring 01:09:00 Metformin Advantage?, Variables, Interventions Testing Program 01:16:02 Berberine, Acarbose, SGLT2 Inhibitors 01:23:48 Blood Glucose & Energy Balance; Caloric Restriction, Aging Biomarkers 01:32:22 Tool: Reading Journal Articles, 4 Questions, Supplemental Information 01:38:10 Article #2, Belief Effects vs. Placebo Effect 01:45:22 Nicotine Effects 01:51:07 Nicotine Doses & Belief Effects, fMRI Scan 02:00:07 Biological Effects, Dose-Dependent Response & Belief Effects 02:05:14 Biology & Beliefs, Significance, Dopamine Response, Non-Smokers 02:10:57 Dose-Dependence & Beliefs, Side Effects, Nocebo Effect 02:19:06 Zero-Cost Support, YouTube Feedback, Spotify & Apple Reviews, Sponsors, Momentous, Neural Network Newsletter, Social Media Title Card Photo Credit: Mike Blabac - https://www.blabacphoto.com Disclaimer: https://hubermanlab.com/disclaimer

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