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REFERENCE for Curious Interested Listeners & Physicians 48,25mar In Part 2 of our deep dive into Mounjaro vs. Ozempic, we’re busting myths and uncovering what doctors aren’t always saying. Here’s what we’ll cover: • Myth 1: “All GLP-1 drugs are the same.” • Reality: Ozempic targets a single pathway, while Mounjaro works on two—leading to potential greater weight loss in some, but it’s not a one-size-fits-all. • Myth 2: “These drugs only make you eat less.” • Reality: They also influence the brain’s reward system, reducing cravings and the emotional drivers of eating, not just physical hunger. We’ll break down how these medications work, the real-world impact, and why individual responses vary. Stay tuned Part 3 for more insights into what doctors might not be telling you about these weight loss treatments! 1. Animal Studies Alhadeff AL, Rupprecht LE, Hayes MR. (2012). Glucagon-like peptide-1 receptor signaling in the ventral tegmental area attenuates food intake. Journal of Neuroscience, 32(25), 8112-8120. Showed GLP-1 drugs reduce food-seeking behavior by acting on brain reward areas. 2. Brain Reward Pathways Dickson SL, Shirazi RH, Hansson C, et al. (2012). The role of GLP‑1 receptor activation in the central regulation of energy balance and reward. Physiology & Behavior, 106(2), 231–238. Explains how GLP-1 receptors in the brain influence eating for pleasure, not just hunger. 3. Incretin Hormones Review Nauck MA & Meier JJ. (2018). Incretin hormones: Their role in health and disease. Diabetes, Obesity and Metabolism. Details the dual role of GLP-1 in gut and brain signaling. 4. The SURPASS-2 Trial Jastreboff, A. M., et al. (2022). Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes (SURPASS-2): A Randomized, Open-Label, Parallel-Group, Phase 3 Trial. This study and provided weight loss data for both tirzepatide (Mounjaro) and semaglutide (Ozempic). 5. The SURPASS Clinical Trials (Review and Meta-Analysis) Frías, J. P., et al. (2022). Insights from the SURPASS Clinical Trials: A Systematic Review and Meta-Analysis of Tirzepatide in Type 2 Diabetes. Diabetes, Obesity and Metabolism. Discusses how the additional GIP receptor activity might contribute to enhanced weight loss. 6. Eli Lilly (Mounjaro) https://www.lilly.com/news/media/media-kits/mounjaro https://mounjaro.lilly.com 7. Novo Nordisk (Ozempic) https://www.novonordisk.com.au/our-products-for-healthcare-professionals.html https://rss.medsinfo.com.au/no/pi.cfm?product=nopozemp

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GLP-1 weight loss pharmaceuticals will cause equally pervasive second-order effects to functional CPG categories as AI will trigger regarding business productivity. Despite our collective ambiguity on the true extent, I believe the skyrocketing popularity of weight loss pharmaceuticals has already tangibly disrupted many aspects of the CPG industry. The problem (i.e. obesity epidemic) has reached unprecedented levels...as the most recent CDC statistics show more than 100 million people are considered obese by the U.S. government…and also candidates for weight loss pharmaceuticals. There are the obvious health-related motivating factors like managing diabetes or cardiovascular disease…but also something deeper at play involving social ideals, which has kept Americans extremely interested in weight management. Another core reason why weight management is such a mass appeal dietary outcome is that American modern life constantly messes with our ability to achieve even a fraction of the standard we set. So, it shouldn’t be surprising to learn that the United States is by far the world’s largest weight loss pharmaceuticals market, currently accounting for an estimated two-thirds of total dollars spent globally. Since its 2017 approval as a diabetes treatment, semaglutide (Ozempic and Wegovy) has become one of the most popular prescription drugs in the United States. But while their intended purpose was to moderate insulin levels in Type 2 diabetics, new users are overwhelmingly adopting these drugs for its notable weight loss side effects. These unmet medical needs are more than enough to build demand…but countless popular celebrities (like Oprah Winfrey), positively sharing their experience, has further fueled its meteoric rise. In fact, marketplace experts now estimate annual weight loss drug sales reaching $150 billion by 2033. But let’s talk about results…because within weight management categorical spending, consumers want outcomes. Users of Ozempic and similar drugs, that followed a diet and exercise program, had an average weight loss of 15 to 20 percent and significant reductions in cardiovascular risk factors. So, I've laid out the massive problem and a very probable solution, but what about predicted outcomes (and second-order effects)? Does the “Age of Ozempic” indeed continue reshaping the CPG industry or will it quickly turn into overhyped garbage after post-market surveillance showed too many public health safety questions? Regardless, I believe it’s easiest to think about “the Age of Ozempic” as being a major catalyst that fundamentally shifts consumer behavior. And although the weight loss achieved through these pharmaceuticals has been remarkable, concerns about the long-term sustainability of these results persist. Additionally, for many users…GLP-1 drugs are not a long-term commitment but rather a step along the way in their weight management journey. But that naturally sets up three adjacent opportunities for functional CPG companies to market their products as part of the onramp, during, and offramp portions of a continued healthy lifestyle change. Finally, I'll focus on the potential impacts within the intersecting categories of functional foods, functional beverages, and nutritional supplements. This includes how these functional CPG categories can bridge nutritional gaps (i.e. protein powder) and help combat against the side effects of weight-loss drugs (i.e. muscle loss and HMB). #glp1 #supplements #strategy I appreciate each and every one of you that took even a moment of your time to watch this video. I know your time and attention are your biggest assets and I hope you got adequate value in return from this content. Thank you from the bottom of my heart! ✅ CHECK OUT THE PODCAST ON THE FOLLOWING PLATFORMS: 🍎Apple: https://apple.co/3aPKOOJ 👽Spotify: https://spoti.fi/38N9nur 🔍 Google: https://bit.ly/2vgVTcy ⚓Anchor: https://anchor.fm/joshua-schall FOLLOW ME ON MY SOCIAL MEDIA ACCOUNTS ►LINKEDIN https://www.linkedin.com/in/joshuaschallmba ►TWITTER https://www.twitter.com/joshua_schall ►INSTAGRAM https://www.instagram.com/joshua_schall ►FACEBOOK https://www.facebook.com/jschallconsulting ►MEDIUM https://medium.com/@joshua-schall About Joshua Schall of J. Schall Consulting: Joshua is consumer packaged goods (CPG) Strategist and Entrepreneur that focuses on the product categories of value-added (or functional) food, beverage, beauty, and nutritional supplements. He was an early advocate for digital grocery optimization and is an expert at the entrepreneurial ideation to consumerization cycle. Recently, he has shifted that decade of knowledge into early-stage investments, board membership, and public speaking engagements. His YouTube channel is a walk through his daily life and a peek into his business musings. Enjoy a look into his life through the lens! ►EMAIL [email protected]

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