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#nephrology #kidneytransplantation #glp1 #type2diabetes Previous research suggested that glucagon-like peptide-1 (GLP-1) agonists, such as semaglutide, liraglutide, and dulaglutide, had benefits for recipients of kidney transplants with a history of type 2 diabetes. Yet the question remained whether clinicians should prescribe the drugs to transplant recipients because of their association with inflammation of the pancreas and liver problems and the potential for an increased risk of a rare form of thyroid cancer. A recent study published in The Lancet Diabetes and Endocrinology reviewed the medical records of 18,016 kidney transplant recipients with pretransplant diabetes and found that those who were prescribed GLP-1 agonists, mostly within 3 years of receiving a transplant, were 49% less likely to experience organ failure and had a 31% reduced risk of dying within 5 years of starting the medication. In addition, they did not have a higher risk for inflammation in the pancreas, liver problems, or thyroid cancer, although they did have an increased risk of developing diabetic retinopathy. Study co-author Babak J. Orandi, MD, PhD, of the New York University (NYU) Grossman School of Medicine spoke with Nephrology Times about the study and its findings.

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Novo Nordisk, a leading pharmaceutical company, has announced a significant investment of $1.09 billion to expand its manufacturing facility in Minas Gerais, Brazil. This strategic move aims to increase the production of GLP-1-based medications, including Ozempic and Wegovy, essential for diabetes and obesity treatments.​ Key Highlights: Facility Expansion: Construction of a new 74,000-square-meter facility has commenced, with operations expected to begin by 2028.​ Global Supply Impact: The expansion will enhance the global availability of Ozempic and Wegovy, addressing the rising worldwide demand for these treatments.​ Strategic Importance of Brazil: Brazil is among Novo Nordisk’s top five markets and serves as an export hub to over 70 countries, highlighting its significance in the company's global operations.​ Competitive Landscape: This investment comes as competition in the GLP-1 market intensifies, with other pharmaceutical companies planning to introduce generic versions of Ozempic following patent expirations.​ This development underscores Novo Nordisk's commitment to scaling its production capabilities in response to the growing demand for its diabetes and obesity treatments.​ For a comprehensive analysis of this significant development and its implications for the pharmaceutical industry, watch our detailed video. If you find this content informative, please like, comment, and subscribe to stay updated on the latest pharmaceutical news and insights.

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I’ve been on Mounjaro (tirzepatide) for 5 months now, and I’ve lost two and a half stone — but this journey has been about more than just the weight. In this video, I share my my honest experience with my 10mg doses and what seems to be a new symptom im feeling. Also getting back on track! I’ll cover: ✅ The side effects I dealt with ✅ What worked for me (and what didn’t) ✅ My tips for staying on track Whether you’re considering Mounjaro or already on it, I hope this video gives you some insight, support, and maybe even inspiration. 🔔 Subscribe if you want to follow my ongoing journey. 💬 Drop your questions or your own experience in the comments — let’s support each other! #mounjaroupdate #weightlossupdate #mounjaroweightloss #Tirzepatide #glp1journey #glp1

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In this episode, Dr. Cole breaks down how to naturally boost your body’s GLP-1 levels. Naturally increasing the same hormone behind weight-loss drugs like Ozempic and Wegovy, without relying on medication. From diet and exercise to fasting and supplements, here are 7 research-backed ways to enhance metabolism, regulate appetite, and feel full longer. 00:00 – What Is GLP-1 and Why It Matters 01:19 – Tip #1: GLP-1-Boosting Diet (Protein, Fats, Fiber) 05:09 – Tip #2: Exercise and Movement 06:22 – Tip #3: Prioritize Quality Sleep 07:32 – Tip #4: Intermittent Fasting 08:41 – Tip #5: Manage Stress & Cortisol 09:52 – Tip #6: Stay Hydrated 11:12 – Tip #7: GLP-1-Boosting Supplements 12:58 – Recap: 7 Natural Ways to Boost GLP-1 13:37 – Final Thoughts & Personalized Support ----------------------------------------------------------------------------- ABOUT DR. WILL COLE: Dr. Will Cole is a leading functional medicine expert who consults people around the globe via one of the first functional medicine telehealth centers in the world. Named one of the top 50 functional and integrative doctors in the nation, Dr. Will Cole specializes in clinically investigating underlying factors of chronic disease and customizing a functional medicine approach for thyroid issues, autoimmune conditions, hormonal imbalances, digestive disorders, and brain problems. He is also the host of the popular The Art Of Being Well podcast and the author of Gut Feelings, Ketotarian, The Inflammation Spectrum, and the New York Times bestseller Intuitive Fasting. ------------------------------------------------------------------------------ FOLLOW ALONG WITH DR. WILL COLE ON SOCIAL: Instagram: https://www.instagram.com/drwillcole/ Facebook: https://www.facebook.com/doctorwillcole/ Twitter: https://twitter.com/drwillcole?lang=en TikTok: https://www.tiktok.com/@drwillcole?la... Pinterest: https://www.pinterest.com/drwillcoleinfo Functional medicine for everyday people around the world.

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Exploring GLP-1 Agonists and Their Role in Weight Loss

The rising tide of obesity has led to a growing interest in weight loss solutions that are not only effective but also safe and sustainable. Among the various options available, GLP-1 agonists have emerged as a pivotal player in the realm of pharmacological weight loss. These medications mimic the effects of a hormone called glucagon-like peptide-1 (GLP-1), which plays a crucial role in both glucose metabolism and appetite regulation. By helping individuals manage their weight, GLP-1 agonists have gained prominence in clinical settings and among patients struggling with weight-related health issues.

The introduction of GLP-1 agonists marks a transition from traditional weight loss strategies that often rely solely on dietary modifications and exercise. These medications are designed to not only assist with weight loss but also improve adherence to healthier lifestyle choices. By addressing the physiological roots of weight management, GLP-1 agonists provide a pharmacological adjunct to behavioral interventions. As the medical community continues to explore the multifaceted challenges of obesity, GLP-1 agonists present a comprehensive approach to promote sustained weight loss and improve associated health conditions.

This article delves into the key benefits of GLP-1 agonist weight loss therapy and identifies the types of individuals who may benefit the most from these treatments. From reducing appetite to improving metabolic health, the advantages of GLP-1 agonists extend far beyond mere weight loss. Furthermore, understanding who can best utilize these medications is essential in ensuring they are deployed effectively, maximizing their potential impact on individual health outcomes. As research continues to evolve, it becomes increasingly important for patients and healthcare providers to stay informed about the benefits and considerations surrounding the use of GLP-1 agonists for weight management.

Significant Appetite Suppression

One of the hallmark benefits of GLP-1 agonist therapy is its potent ability to suppress appetite. These medications act on specific areas of the brain that are integral to hunger and satiety signals. Users often report a marked decrease in food cravings, making it easier to adhere to dietary restrictions that are usually challenging during any weight loss journey. This mechanism of appetite regulation is especially beneficial for individuals who experience emotional or binge eating, as GLP-1 agonists facilitate a more mindful and controlled eating behavior.

By enhancing feelings of fullness and satisfaction after meals, GLP-1 agonists can help patients reduce their overall caloric intake without feeling deprived. This reduction in hunger is not only beneficial for primary weight loss but also plays a crucial role in maintaining weight loss over time. Over the long term, individuals who are able to manage their appetite may find it easier to sustain their new healthy habits, leading to better overall health outcomes and reduced risk of weight regain.

The appetite-suppressing effects of GLP-1 agonists can also have a psychological benefit. As patients experience success in their weight loss journey, they are likely to feel more motivated and empowered. The reduction in cravings and the ability to control portion sizes can instill a sense of discipline and improve self-efficacy. Ultimately, this psychological reinforcement solidifies positive dietary changes and instills a healthy relationship with food.

Enhanced Glycemic Control and Metabolic Health

In addition to appetite suppression, GLP-1 agonists are known for their role in enhancing glycemic control. These medications facilitate better regulation of blood sugar levels by promoting insulin secretion in response to elevated glucose. For individuals struggling with obesity, poor glycemic control often leads to type 2 diabetes and other metabolic disorders. By improving insulin sensitivity and reducing blood sugar spikes after meals, GLP-1 agonists can help prevent or mitigate these conditions.

The dual action of GLP-1 agonists—reducing appetite while simultaneously improving glycemic control—can lead to favorable metabolic outcomes. Research has demonstrated that individuals using these medications not only lose weight but also experience improvements in lipid profiles, including reductions in triglycerides and increased levels of good cholesterol (HDL). These changes can significantly decrease the risk of cardiovascular diseases often associated with obesity and diabetes.

Moreover, the improvement in glycemic control can provide individuals with a greater sense of control over their health. Patients may feel more empowered to engage in physical activity, adopt healthier eating habits, and ultimately take a proactive approach to their overall well-being. The holistic benefits of enhanced metabolic health extend beyond weight loss to encompass improved quality of life and reduced healthcare costs in the long run.

Support for Sustainable Weight Loss and Maintenance

Achieving weight loss is often just the first step; maintaining that weight loss presents another set of challenges. GLP-1 agonists are uniquely positioned to facilitate not only weight reduction but also the maintenance of that weight loss over time. Unlike traditional dieting methods that can result in yo-yo dieting or weight regain, the sustained appetite suppression and metabolic benefits provided by GLP-1 agonists support long-term lifestyle changes.

Patients using GLP-1 agonists frequently report that their approach to food and eating becomes more mindful. This intentional shift can lead to improved dietary choices and decreased occurrences of overeating. With the aid of these medications, individuals are more likely to adhere to their weight management goals, fostering habits that promote continued health even after discontinuing the medication. This characteristic makes GLP-1 agonists stand out as a substantial alternative in combating chronic weight issues.

The challenge of maintaining behavioral adoptions can be particularly daunting for individuals who have historic patterns of weight regain. GLP-1 agonists can mitigate some of these psychological hurdles by offering a sense of empowerment through successful outcomes. As patients witness the tangible results of their efforts, they may develop a strengthened resolve to persist with their dietary and activity modifications. The social and emotional benefits gained from this sustained commitment to weight management can also enhance overall life satisfaction, creating a positive feedback loop that encourages ongoing wellness.

Reduced Risk of Comorbid Conditions

The relationship between obesity and comorbid conditions, such as cardiovascular disease and type 2 diabetes, is well-established. By aiding weight loss, GLP-1 agonists have the potential to reduce the prevalence and severity of these associated health issues. Clinical studies suggest that patients on GLP-1 agonists demonstrate significant reductions in key health metrics, including blood pressure, cholesterol levels, and glycated hemoglobin (HbA1c), which together can contribute to a lower risk profile for a variety of serious conditions.

Beyond direct health improvements, the psychological benefits associated with weight loss can also yield dividends in terms of reduced healthcare utilization. As individuals address obesity-related health risks through pharmacological interventions, they may experience fewer complications requiring medical attention. The prospect of better health outcomes translates to enhanced quality of life and greater autonomy, as patients are less hindered by weight-related ailments.

The comprehensive health benefits associated with GLP-1 agonists underscore the importance of a multifactorial approach to obesity management. For patients dealing with the dual burden of obesity and coexisting health issues, GLP-1 agonists can serve as a powerful tool in breaking the vicious cycle of weight gain, disease progression, and declining health. Improving health markers not only enhances physical well-being but also empowers individuals to reclaim their lives, engage more fully in their communities, and foster deeper emotional connections with themselves and others.

Personalized Weight Loss Therapy for Specific Populations

GLP-1 agonists offer a tailored approach to weight management, catering to the unique needs of diverse populations. For individuals who have not achieved substantial weight loss through conventional means, such as diet and exercise alone, these medications provide an alternative strategy that may facilitate meaningful outcomes. Moreover, they can address the multifaceted nature of obesity and its related comorbidities.

This personalized approach is invaluable for specific patient populations, including those with type 2 diabetes or those who are prediabetic. For individuals in these groups, weight management is intricately linked to their glycemic control and overall health status. The ability of GLP-1 agonists to enhance both weight loss and metabolic health makes them an appealing choice for healthcare providers looking to optimize treatment plans for their patients.

Additionally, GLP-1 agonists can be beneficial for individuals facing psychological barriers to weight loss, such as those we discussed previously regarding emotional or binge-eating disorders. Providing pharmaceutical support can create an environment where patients feel more confident and empowered to make sustained changes in their lifestyle. By acknowledging the individuality of each person’s experience, GLP-1 agonists stand as a promising intervention that aligns with the diverse needs of those seeking weight management solutions.

Frequently Asked Questions

As the interest in GLP-1 agonists for weight loss continues to grow, several common inquiries arise. One prevalent question is whether these medications are suitable for every individual seeking weight loss. It is important to note that GLP-1 agonists are typically recommended for individuals with a body mass index (BMI) of 30 or greater, or those with a BMI of 27 or greater who have obesity-related comorbidities. Consulting with a healthcare provider is essential to determine candidacy and to develop a personalized treatment plan.

Another frequent query pertains to the safety and side effects associated with GLP-1 agonists. While many users tolerate these medications well, some may experience gastrointestinal issues such as nausea or diarrhea, especially upon initiation. These side effects often diminish over time as the body adapts to the medication. Healthcare providers can guide patients through their experiences and provide strategies to minimize any adverse effects, ensuring a safer and more comfortable transition.

Individuals often wonder about the long-term efficacy of GLP-1 agonists and whether weight loss persists after discontinuation. Studies indicate that while many individuals may regain some weight after stopping the medication, a significant number maintain a portion of their weight loss if they have adhered to newfound healthy lifestyle changes. Ultimately, integrating medication with behavioral interventions forms the foundation for lasting results and offers assurance to those committed to their weight management journey.

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Do ‘Natural GLP-1 Supplements’ Actually Work As Well As Ozempic? GLP-1 receptor agonists like Ozempic and Wegovy have a great deal of scientific data to support their use — and they can assist with people dropping a lot of pounds. In any case, is it conceivable to come by similar outcomes from a supplement?

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Not all magnesium supplements will provide the same benefits! Find out about the best magnesium supplements so you can experience the true benefits of magnesium. 0:00 Introduction: What magnesium is best? 0:45 Magnesium benefits 1:36 Magnesium oxide 3:34 Magnesium sulfate 3:45 Magnesium orotate 4:02 Magnesium taurate 4:17 Magnesium lactate 4:55 Magnesium citrate 5:20 Magnesium malate 5:32 Magnesium threonate 5:57 Magnesium glycinate 6:57 Magnesium dosage Today, I’m going to tell you about the best magnesium supplements and the worst! Magnesium is vital for the following: •Energy production •Vitamin D function •Vitamin K2 function •Preventing kidney stones •Heart health •Blood pressure •Preventing muscle cramps •Preventing migraines •Sleep Magnesium supplements contain different forms of magnesium. Let’s take a look at them, starting with the worst. 1. The worst magnesium - Magnesium oxide is the worst yet most common magnesium supplement. It only has a 4% absorption rate. It’s also very expensive! 2. Magnesium sulfate has a 10% absorption rate and a high laxative effect. It may help relax your muscles superficially. 3. Magnesium orotate has a 15% absorption rate. This form of magnesium can penetrate the cell and increase energy. Magnesium orotate also works as an antioxidant and supports the DNA. 4. Magnesium taurate has a 20% absorption rate and supports heart health, blood pressure, and the nervous system. 5. Magnesium lactate has a 25% absorption rate and is more gentle on the GI system. It supports the cardiovascular system and can improve energy. Magnesium lactate is often used topically, which may be beneficial for your muscles. 6. Magnesium citrate has a 30% absorption rate. It can help prevent kidney stones and is good for cardiovascular issues and blood pressure. It can also help with detoxification. 7. Magnesium malate has a 40% absorption rate. It’s beneficial for chronic fatigue syndrome and fibromyalgia. 8. Magnesium threonate has a 75% absorption rate. It supports cognitive function and is a good form of magnesium for sleep. 9. The best magnesium - Magnesium glycinate is the most absorbable type of magnesium. There are a lot of magnesium glycinate benefits. It’s gentle on the GI system, helps prevent muscle spasms, supports sleep and relaxation, and reduces stress. Magnesium glycinate may help relieve migraines and won’t interfere with other minerals. Consider taking 400 mg of magnesium glycinate each night as a maintenance dose. Double this for a therapeutic dose and take throughout the day. Dr. Eric Berg DC Bio: Dr. Berg, age 59, is a chiropractor who specializes in Healthy Ketosis & Intermittent Fasting. He is the author of the best-selling book The Healthy Keto Plan, and is the Director of Dr. Berg Nutritionals. He no longer practices, but focuses on health education through social media. Follow Me On Social Media: YouTube: https://www.youtube.com/@Drberg/ YouTube Shorts: https://www.youtube.com/@UCpWhiwlOPxOmwQu5xyjtLDw Facebook: https://www.facebook.com/drericberg Instagram: https://www.instagram.com/drericberg/ Spotify Podcast: 🎧 https://drbrg.co/DrBerg-Spotify TikTok: https://www.tiktok.com/@drbergofficial X: https://x.com/dr_ericberg Disclaimer: Dr. Eric Berg received his Doctor of Chiropractic degree from Palmer College of Chiropractic in 1988. His use of “doctor” or “Dr.” in relation to himself solely refers to that degree. Dr. Berg is a licensed chiropractor in Virginia, California, and Louisiana, but he no longer practices chiropractic in any state and does not see patients, so he can focus on educating people as a full-time activity, yet he maintains an active license. This video is for general informational purposes only. It should not be used to self-diagnose, and it is not a substitute for a medical exam, cure, treatment, diagnosis, prescription, or recommendation. It does not create a doctor-patient relationship between Dr. Berg and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. #keto #ketodiet #weightloss #ketolifestyle Thanks for watching! Give magnesium glycinate a try. I’ll see you in the next video.

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Subscribe for the latest science breakdowns! And, become a member to chat 1:1 about science related topics! GLP-1, or glucagon-like peptide-1, is a hormone that plays a crucial role in regulating blood sugar levels and appetite. GLP-1 agonists are drugs designed to mimic the action of this hormone, which can be beneficial in certain medical conditions. These pharmaceuticals are often used in the treatment of type 2 diabetes and obesity. Learn more about metabolism in free medical education webinars found here: https://www.mycme.com/courses/managing-major-mental-illness-with-dietary-change-9616 ***Mistake on board, should read & I should be saying GLP-1 agonists, not antagonists.

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