Transcript Queen Latifah Weight Loss Health Journey👀 Do you want to get fit without dieting or exercising by tricking your body? This sounds like sci-fi, or like a scammy ad for a fat burning supplement. However, given recent advances in exercise mimetics and strong momentum behind treating obesity pharmacologically (most notably, semaglutide - Ozempic/Wegovy and tirzepatide - Mounjaro/Zepbound), this idea could reality sooner than some expect. 🧠 In this video we will discover SLU-PP-332, a small molecule that mimics endurance training and dieting in mice - without exercise or eating less. We will cover 1) the biochemical basics of exercise mimetics and mechanisms of action, 2) take a look at pre-clinical data of different compounds, and 3) as always, review chemistry concepts. https://www.patreon.com/totalsynthesis 🚀 Thanks to all channel supporters!!! https://www.instagram.com/totalsynthesis_official/ 👉 Follow me on Instagram for updates on random research, mechanism quizzes and interesting news! https://total-synthesis.com https://total-synthesis.com/exercise-mimetics-trick-your-body-into-burning-fat/ Disclaimer - This channel does not provide medical advice! No information on this channel is intended to be a substitute for professional medical advice, diagnosis or treatment. Always seek the advice of your physician or other qualified health care provider with any questions you may have regarding a medical condition or treatment and before undertaking a new health care regimen, and never disregard professional medical advice or delay in seeking it because of information on Youtube. 00:00 Trick your body into losing weight - is it possible? 01:22 Obesity problem, logic behind using drugs and limitations 02:31 GLP1 agonists 03:01 Exercise mimetic basics 04:04 Resveratrol's exercise mimicry, health benefits and unexpected effects 06:03 ERR up/downregulation can trigger major effects - transgenic and knock-out mice 09:18 Drug design logic behind SLU-PP-332 11:02 Organic synthesis of SLU-PP-332 (too easy) 11:32 Molecular, structural, physiological and metabolic effects of SLU-PP-332 15:05 Outlook and conclusion Key references: - PGC-1α, Inflammation, and Oxidative Stress: An Integrative View in Metabolism | Oxidative Medicine and Cellular Longevity, 2020, 1452696 - Caloric restriction and exercise “mimetics’’: Ready for prime time? | Pharmacological Research 2016, 103, 158 - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha | Cell 2006, 127, 1109 - Distribution and Effects of Estrogen Receptors in Prostate Cancer: Associated Molecular Mechanisms | Frontiers in Endocrinology 2022, 12, 811578 - Identification and structure-activity relationship of phenolic acyl hydrazones as selective agonists for the estrogen-related orphan nuclear receptors ERRbeta and ERRgamma | J Med Chem 2005, 48, 3107 - Exercise and PGC-1 alpha-Independent Synchronization of Type I Muscle Metabolism and Vasculature by ERR gamma | Cell Metabolism 2011, 13, 283 - Estrogen-related receptor-α coordinates transcriptional programs essential for exercise tolerance and muscle fitness | Mol Endocrinol 2014, 28, 2060 - Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity | ACS Chem. Biol. 2023, 18, 756 - A Synthetic ERR Agonist Alleviates Metabolic Syndrome | J. Pharmacol. Exp. Ther. 2023, 001733 Another related SLU-PP compound with more chemistry information behind it: Development and pharmacological evaluation of a new chemical series of potent pan-ERR agonists, identification of SLU-PP-915 | Eur J Med Chem 2023, 258, 115582 Some recommended books on organic synthesis: - Clayden, Greeves, Warren; Organic Chemistry (basic organic chemistry knowledge) - Wyatt, Warren; Organic Synthesis: The Disconnection Approach (excellent introduction to retrosynthesis) - Kurti, Czako; Strategic Applications of Named Reactions in Organic Synthesis (extensive toolkit of functional group reactions and applications thereof with common conditions) - Nicolaou; Classics in Total Synthesis 1-3 (the ultimate total synthesis trilogy) - Nicolaou; Molecules That Changed the World (the world's most important molecules and their impact on everyday life) - Carreira, Kvaerno; Classics in Stereoselective Synthesis (compilation of the groundbreaking methods of stereoselective synthesis and application to synthesis of stereochemically complex structures)Day 3 Full Day Of Eating Diet Plan For Weight Loss Dietician Sunita Roy ChowdhuryOranges vs Samosa – What’s Really Worth Your Money? 🍊 vs 🥟 One fuels your immunity, the other fuels fat gain! 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In diesem Artikel werden wir einige effektive Rezepte für Eiweiß Shakes vorstellen, die Sie in Ihre Diät integrieren können. Warum kann ein Eiweiß Shake beim Abnehmen helfen? Eiweiß ist ein wichtiger Nährstoff, der beim Abnehmen helfen kann. Proteinshakes sind eine einfache und bequeme Möglichkeit, die optimale Menge an Eiweiß zu konsumieren, die für den Aufbau und die Reparatur von Muskelgewebe benötigt wird. Wenn Sie regelmäßig proteinreiche Shakes trinken, können Sie Ihren Stoffwechsel ankurbeln und die Fettverbrennung steigern. Darüber hinaus können Eiweiß Shakes helfen, den Hunger zu kontrollieren und Heißhungerattacken zu verhindern. Eine weitere Möglichkeit, wie Eiweiß Shakes beim Abnehmen helfen können, ist durch die Unterstützung beim Muskelaufbau. Wenn Sie regelmäßig Sport treiben und Ihren Körper mit ausreichend Protein versorgen, können Sie Muskelmasse aufbauen. Muskelmasse verbrennt mehr Kalorien als Fettgewebe, sodass Sie auch im Ruhezustand mehr Kalorien verbrennen. 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For business opportunities email us at [email protected] #shellymarieredmond #dietitian #lowcarb #prediabetes #diabetesOzempic Oz Land Weeks 12 For Diabetes And Weight Loss What HappenedAre you taking or thinking about taking the new GLP-1 RA weight loss medications (Semaglutide, Ozempic, Wegovy, Tirzepatide, Mounjaro, Zepbound)? This webinar with obesity medicine physician Jonathan Bonnet, MD, MPH, a GLP-1RA expert, will answer all your questions about the medications, how they work, their benefits, their side effects, and how they can be combined with lifestyle changes to optimize your weight loss and body composition. Support materials can be found in the Full Plate Living membership. Join now to gain access to more workshops like this and nutrition programs you can do at your own pace. It's 100% free. Join now at: https://fullplateliving.org/ Dr. Bonnet is board-certified in family, sports, obesity, and lifestyle medicine. He’s an associate professor at Stanford University School of Medicine and program director of medical weight loss at Palo Alto VA. He completed his undergraduate and medical school degrees at Ohio State University, family medicine residency at Duke University, and sports medicine fellowship at the University of Florida. He also holds a master’s degree in public health from Harvard. 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C O N N E C T 💥 Join our TRANSFORM FB group ➡️ https://www.facebook.com/groups/transformbyjuliettewooten 💥 GRAB YOUR WORKOUT CALENDAR HERE ⮕ https://www.juliettewooten.com 💥 INSTAGRAM https://bit.ly/3KLYcqk 💥 FREE WEIGHT LOSS MEAL PLAN ⬇️ https://juliettewooten.com/app/ ⬅ FREE TRIAL 💥 My EQUIPMENT and NUTRITION LIST FOR BEST POSSIBLE RESULTS! ⮕ https://www.amazon.com/shop/juliettewooten D I S C L A M E R This is my own personal workout program and may not be suited for your specific health or medical condition. You should consult with your physician before beginning any exercise program. Transform by Juliette Wooten and/or Juliette Wooten is not responsible or liable for any injury from using the video content. You agree that no information in any content provided by Transform by Juliette Wooten and/or Juliette Wooten can be taken as medical or other health advice. 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