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Please check with a physician if you have any health questions or concerns about medical science and supplements prior to engaging in them. #dopamine #testosterone #motivation #science #healthUnlock Fatburning With Ketogenic Dietthe Secret To Lowering Insulin Boosting Energy ShortsIn continuation of my update "Metformin" GLP-1 receptor agonists, a class of drug used to treat type 2 diabetes, likely trump the widely prescribed metformin for curbing dementia risk in people with the condition, finds the largest study of its kind, published in the open access journal BMJ Open Diabetes Research & Care. The findings suggest that future clinical guidelines for the treatment of type 2 diabetes would do well to consider prioritizing drugs with both blood glucose and neuroprotective effects, say the researchers. Published research suggests that both GLP-1 receptor agonists and metformin, which are widely used to treat type 2 diabetes, protect the brains of people with the disease. But as yet there have been no direct real-world comparisons of the potential impact of these drugs on dementia risk—a risk that is around 70% higher in people with type 2 diabetes. To explore this further, the researchers drew on anonymized electronic health records from a global health research network (Trinetx) spanning the period 2004 to 2024 to track the development of dementia in patients with type 2 diabetes, treated with either GLP-1 receptor agonists or metformin (87,229 patients in each group; average age 58) for at least six consecutive months. There was no significant difference in vascular dementia risk between the two types of drug when used as first line therapy. But GLP-1 receptor agonist use was associated with a significantly lower cumulative (10%) risk of developing dementia, overall, with an incidence of almost 2.5% (2,130 people) compared with an incidence of nearly 5% (4,215 people) for metformin. And specifically, taking this type of drug was associated with a 12% lower risk of developing Alzheimer's disease, and a 25% lower risk of developing non-vascular dementias than metformin use. Further in-depth analyses showed that these positive effects were evident across all age groups, but with the strongest effect among the over 60s, women, and those of white ethnicity. Risk of death from any cause was also lower: nearly 5% of those treated with GLP-1 receptor agonists died compared with nearly 9% of those treated with metformin. "Both medications demonstrate neuroprotective properties, such as reducing neuroinflammation and oxidative stress, improving insulin sensitivity, and enhancing cerebrovascular health, which likely contribute to their benefits in overall dementia," explain the researchers. But unlike metformin, whose benefits primarily derive from systemic metabolic effects, GLP-1 receptor agonists exert direct central nervous system effects by crossing the blood-brain barrier, they add. "However, the multifactorial nature of [vascular dementia], driven by cerebrovascular damage, such as small vessel disease and white matter lesions, poses significant challenges for pharmacological interventions targeting metabolic or neurodegenerative pathways," they continue. This is an observational study, and as such, no firm conclusions can be drawn about cause and effect. And the researchers point out that the tracking period, while sufficient for observing dementia outcomes, may not fully capture long-term cognitive effects, especially given the progressive nature of Alzheimer's disease. 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The Origins of Pure Life Keto Pure Life Keto was founded by a team of health and wellness experts who wanted to create a supplement that could help people get the most out of their ketogenic diet. They understood the struggles that many individuals face when trying to reach ketosis, which is why they developed a formula that contains the perfect blend of ingredients to support the body’s natural ketone production. With a focus on quality and transparency, Pure Life Keto is manufactured in a facility that follows strict Good Manufacturing Practices (GMP) guidelines. This ensures that every bottle of Pure Life Keto is of the highest quality and potency, giving users peace of mind that they are getting a safe and effective product. Unlike many other weight loss supplements on the market, Pure Life Keto does not contain any fillers, artificial ingredients, or harmful chemicals. The all-natural formula is designed to be gentle on the body while still providing powerful results. Users can trust that they are putting only the best ingredients into their bodies when they choose Pure Life Keto. How Pure Life Keto Works When you follow a ketogenic diet, your body enters a state of ketosis, where it starts burning fat for energy instead of carbohydrates. This can be a difficult process to achieve on your own, which is where Pure Life Keto comes in. By taking Pure Life Keto supplements, you can give your body the exogenous ketones it needs to reach ketosis faster and stay there longer. The key ingredient in Pure Life Keto is beta-hydroxybutyrate (BHB), which is a type of ketone that your body produces naturally when it is in ketosis. By supplementing with BHB, you can jumpstart the ketosis process and experience rapid weight loss results. BHB also helps to curb cravings and improve mental clarity, making it easier to stick to your ketogenic diet plan. In addition to promoting weight loss, Pure Life Keto also offers a range of other health benefits. Many users report feeling more energized and focused throughout the day, thanks to the sustained energy levels provided by ketosis. Others also notice improvements in their skin, digestion, and overall well-being after incorporating Pure Life Keto into their daily routine. The Success of Pure Life Keto Since its appearance on Shark Tank, Pure Life Keto has become a sensation in the weight loss industry, with countless users sharing their success stories online. Many people have reported losing significant amounts of weight in a short period of time, all thanks to the power of Pure Life Keto. Users also appreciate the ease of use and convenience of Pure Life Keto supplements, making it simple to incorporate into their busy lifestyles. simply health acv shark tank fat burning pills shown on shark tank shark tank diet tablet fat burning pills shown on shark tank shark tank episode keto pills One of the reasons for Pure Life Keto’s success is its commitment to customer satisfaction. The company offers a 100% money-back guarantee, so users can try Pure Life Keto risk-free and see the results for themselves. The positive reviews and testimonials pouring in from satisfied customers further solidify Pure Life Keto’s reputation as a top-notch weight loss supplement that delivers on its promises. Whether you are just starting your ketogenic journey or looking to enhance your current weight loss efforts, Pure Life Keto may be the perfect solution for you. With its natural, effective formula and proven results, Pure Life Keto is truly a Shark Tank sensation that is changing the way people approach weight loss. FAQ about Pure Life Keto 1. How long does it take to see results with Pure Life Keto? Results may vary from person to person, but many users report seeing noticeable changes within the first few weeks of taking Pure Life Keto. Consistency is key, so sticking to a healthy diet and exercise routine while taking Pure Life Keto is crucial for maximum results. 2. Are there any side effects of taking Pure Life Keto? Pure Life Keto is made with natural ingredients and is generally well-tolerated by most users. However, some people may experience minor side effects such as headaches, nausea, or digestive issues when they first start taking the supplement. These symptoms usually subside as the body adjusts to the ketosis process. 3. Can I take Pure Life Keto if I’m not following a ketogenic diet? While Pure Life Keto is specifically designed to support a ketogenic diet, it can still be beneficial for individuals who are not strictly following a keto plan. The exogenous ketones in Pure Life Keto can help boost energy levels, curb cravings, and promote weight loss, even if you are not in ketosis. 4. How should I take Pure Life Keto for best results? For optimal results, it is recommended to take two Pure Life Keto capsules daily with a glass of water. 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