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By the end of treatment (4 weeks), serum blood glucose, HOMA-IR, insulin and cardiac enzymes (LDH, CK-MB) were measured. Also, the cardiac histopathology, myocardial oxidative stress markers (MDA, GSH and CAT) and norepinephrine (NE), myocardial fibrosis, the expression of caspase-3, TGF-, TNF- and tyrosine hydroxylase (TH) in myocardial tissues were measured. Results: T2DM caused significant increase in serum glucose, HOMA-IR, serum CK-MB and LDH (p less than 0.05). Also, DM caused significant myocardial damage and fibrosis, elevation of myocardial MDA, NE with upregulation of myocardial caspase-3, TNF-, TGF- and TH and significant decrease in serum insulin and myocardial GSH and CAT (p less than 0.05). Administration of either GLP1 analog and SGLT2i caused in significant improvement in all studied parameters (p less than 0.05). Conclusion: We concluded that either of GLP1 and SGLT2i exhibited cardioprotective effects against DCM in T2DM with the upper hand for SGLT2i. 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When Semaglutide and Phentermine are used together, they target different mechanisms in the body to promote weight loss. Semaglutide helps regulate appetite and food intake, while Phentermine suppresses appetite and boosts energy levels, helping individuals consume fewer calories and burn more energy through physical activity. This dual action can potentially lead to more significant weight loss results compared to using either medication alone. Research studies have shown promising results regarding the effectiveness of combining Semaglutide and Phentermine for weight loss. A study published in the New England Journal of Medicine found that individuals who received the combination of Semaglutide and Phentermine experienced greater weight loss compared to those who received a placebo. The study also reported improvements in metabolic health markers, such as blood pressure and cholesterol levels, among those who received the combination treatment. Potential Benefits of Combining Semaglutide and Phentermine There are several potential benefits to combining Semaglutide and Phentermine for weight loss. The dual action of these medications can help individuals achieve better control over their appetite and food intake, making it easier to adhere to a calorie-restricted diet. Additionally, the increase in energy levels from Phentermine can help individuals engage in more physical activity, further enhancing weight loss results. Another potential benefit of combining Semaglutide and Phentermine is the improvement in metabolic health markers. Studies have shown that the combination treatment can lead to reductions in blood pressure, cholesterol levels, and other cardiovascular risk factors, which are important considerations for individuals with obesity who are at risk for developing heart disease and other complications. Furthermore, the combination of Semaglutide and Phentermine may also help individuals sustain their weight loss long-term. By addressing both appetite control and energy expenditure, individuals may be able to maintain their weight loss more effectively and prevent weight regain in the future. This long-term sustainability is crucial for individuals looking to achieve lasting changes in their weight and overall health. Considerations and Potential Side Effects While the combination of Semaglutide and Phentermine shows promise as a powerful duo for weight loss, it is essential to consider potential side effects and risks associated with these medications. Common side effects of Semaglutide include nausea, vomiting, diarrhea, and constipation, while Phentermine may cause insomnia, dry mouth, and increased heart rate. Individuals considering the combination treatment should consult with their healthcare provider to discuss potential side effects, risks, and benefits before starting the medications. It is crucial to ensure that the benefits of weight loss outweigh the potential risks of side effects, especially for individuals with underlying health conditions or contraindications to these medications. In conclusion, the combination of Semaglutide and Phentermine for weight loss offers a promising approach for individuals struggling with obesity. By targeting different mechanisms in the body to promote weight loss, these medications may offer a more powerful and synergistic effect than when used alone. However, it is essential to consult with a healthcare provider to discuss the potential benefits, risks, and considerations before starting the combination treatment. 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In recent years, oral semaglutide has emerged as a promising option for weight loss in individuals with obesity. This article aims to assess the effectiveness of oral semaglutide for weight loss, exploring its mechanism of action, potential benefits, and considerations for use. Mechanism of Action Oral semaglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist that helps regulate blood sugar levels and increase insulin production in response to meals. This medication works by mimicking the effects of incretin hormones produced in the gut, which stimulate insulin secretion and reduce the production of glucagon, a hormone that raises blood sugar levels. By targeting the GLP-1 receptor, oral semaglutide can help improve glycemic control and promote weight loss through its effects on appetite regulation and energy expenditure. One of the key mechanisms of action of oral semaglutide is its ability to slow down the rate at which food moves through the stomach and intestines, leading to increased feelings of fullness and reduced hunger. This delayed gastric emptying can help individuals eat less and make healthier food choices, ultimately leading to a reduction in calorie intake and weight loss. Additionally, oral semaglutide has been shown to decrease food cravings and enhance the body’s response to insulin, making it easier for individuals to control their blood sugar levels and lose weight. Potential Benefits Several studies have demonstrated the potential benefits of oral semaglutide for weight loss in individuals with obesity. In a clinical trial involving over 1,900 participants, oral semaglutide was found to significantly reduce body weight and improve various markers of metabolic health compared to a placebo. Participants who took oral semaglutide also experienced improvements in blood sugar control, cholesterol levels, and blood pressure, indicating its potential to help reduce the risk of cardiovascular disease and other obesity-related complications. In addition to its weight loss benefits, oral semaglutide has been shown to have a favorable safety profile, with relatively few side effects reported in clinical trials. Common side effects of oral semaglutide include nausea, vomiting, and diarrhea, which are usually mild to moderate in severity and tend to improve over time. Serious side effects such as pancreatitis and thyroid tumors are rare but can occur in some individuals, highlighting the importance of careful monitoring and regular follow-up with healthcare providers when using this medication. Considerations for Use Before starting treatment with oral semaglutide, individuals should undergo a thorough medical evaluation to assess their overall health status and determine the appropriate dosage and monitoring plan. This medication is typically taken once daily on an empty stomach, at least 30 minutes before the first meal of the day. It is important to follow the dosing instructions provided by a healthcare provider and avoid skipping doses or taking more than the prescribed amount to avoid potential side effects or reduced effectiveness. Individuals considering oral semaglutide for weight loss should also be aware of potential drug interactions and contraindications that may affect its safety and efficacy. Certain medications, such as oral contraceptives, antibiotics, and antidiabetic agents, can interfere with the absorption or metabolism of oral semaglutide, leading to reduced effectiveness or increased risk of side effects. Additionally, individuals with a history of pancreatitis, thyroid disease, or other serious medical conditions may not be suitable candidates for treatment with oral semaglutide and should consult with a healthcare provider for alternative weight loss options. Summary and Frequently Asked Questions In conclusion, oral semaglutide is a promising medication for weight loss in individuals with obesity, offering multiple benefits for metabolic health and appetite regulation. By targeting the GLP-1 receptor and promoting insulin secretion, oral semaglutide can help individuals achieve and maintain a healthy weight while improving their overall health outcomes. However, it is essential to carefully consider the potential benefits and risks of oral semaglutide before starting treatment and work closely with a healthcare provider to monitor progress and adjust the treatment plan as needed. Here are some frequently asked questions about oral semaglutide for weight loss: 1. 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These medications may be used for the treatment of obesity and chronic weight management in conjunction with a reduced calorie diet and increased physical activity. How do oral GLP-1s work in the body? Regulate appetite and cravings in the brain Slow down food in the stomach to promote satiety How do I store oral GLP-1s? They may be stored at room temperature. No refrigeration required. How will I receive a refill of GLP-1s? You will receive a 60 day supply. The follow up process begins 35 days later. Henry Meds will email you a refill questionnaire to begin the refill process before you run out of medication to make sure that your refill arrives on time. Please ensure you complete the form and submit it in a timely manner to avoid any lapses in your treatment. You and your provider will decide if you are eligible for a refill without a video visit or if a video visit would be beneficial to discuss dose changes or side effects. Contact customer service at any point if there are any questions or concerns. What to Expect It might require 2-4 weeks of treatment before you begin to observe changes in your appetite, and the full effect may not manifest until several weeks into the standard dosage. If you do not notice appetite suppression or weight loss, please reach out to our Care Coordination Team to discuss potential adjustments to your treatment plan with your healthcare provider. Diet, Exercise & Alcohol Water: Focus on sipping water throughout the day to stay hydrated and help alleviate side effects. We recommend a goal of 64 oz/day minimum or an 80 oz/day minimum if you are vigorously exercising. Protein: Protein is crucial for preserving muscle mass during your weight loss journey. Eat your protein FIRST at every meal. Aim for a sequence of protein, vegetables, fruits, and then carbohydrates. We recommend eating at least 30g of protein at each meal. You can calculate your own protein goals by aiming for 1g of protein per lb of your ideal body weight. Resistance Training: The CDC recommends 150 minutes of moderate-intensity physical activity and 2 days of muscle strengthening activity each week. Please discuss with your PCP before starting any new exercise plan. Alcohol: GLP-1s may reduce your cravings for alcohol. If you choose to drink, do so in moderation - 2 drinks or less a day for men or 1 drink or less a day for women. Drinking less is better for health and weight loss than drinking more.Obesityhelp Interview Sandy N Vitamins And Supplements After Weight Loss Surgery Are you struggling to lose weight despite trying various diets and exercise routines? If so, you may have come across the Ree Drummond Weight Loss Gummy, a popular supplement that claims to help people shed pounds effortlessly. But how does it work, and is it really as effective as it claims to be? In this article, we will delve into the science behind the Ree Drummond Weight Loss Gummy and explore whether it can truly help you achieve your weight loss goals. The Science Behind Ree Drummond Weight Loss Gummy The Ree Drummond Weight Loss Gummy is a dietary supplement that is formulated with a unique blend of ingredients designed to promote weight loss. One of the key ingredients in this gummy is garcinia cambogia, a tropical fruit that is believed to aid in weight loss by suppressing appetite and inhibiting the body’s ability to produce fat. Additionally, the gummy contains green tea extract, which is known for its metabolism-boosting properties. By combining these ingredients, the Ree Drummond Weight Loss Gummy aims to help individuals curb their cravings and burn more calories, ultimately leading to weight loss. When you consume the Ree Drummond Weight Loss Gummy, the active ingredients are absorbed into your bloodstream, where they begin to take effect. Garcinia cambogia works by increasing levels of serotonin in the brain, which can help reduce feelings of hunger and prevent overeating. Meanwhile, green tea extract stimulates the body’s metabolism, allowing you to burn more calories throughout the day. By incorporating this supplement into your daily routine, you may find that you have more control over your appetite and are able to make healthier food choices, leading to gradual weight loss over time. It’s important to note that the Ree Drummond Weight Loss Gummy is not a miracle solution for weight loss. While it can be a helpful tool in your journey to shed pounds, it should be used in conjunction with a balanced diet and regular exercise. Additionally, individual results may vary, as factors such as age, gender, and lifestyle habits can all influence the effectiveness of the supplement. If you are considering trying the Ree Drummond Weight Loss Gummy, be sure to consult with your healthcare provider to ensure that it is safe for you to use and does not interact with any medications you may be taking. Tips for Maximizing Weight Loss with Ree Drummond Weight Loss Gummy For those looking to maximize their weight loss results with the Ree Drummond Weight Loss Gummy, there are a few tips to keep in mind. First and foremost, be sure to follow the recommended dosage instructions provided on the packaging. Taking more gummies than directed will not speed up your weight loss progress and may actually be harmful to your health. In addition to taking the gummies as directed, focus on incorporating healthy eating habits into your daily routine. While the Ree Drummond Weight Loss Gummy can help curb your cravings, it’s important to fuel your body with nutritious foods that provide essential vitamins and minerals. Opt for whole, unprocessed foods such as fruits, vegetables, lean proteins, and whole grains to support your weight loss goals. Furthermore, remember to stay hydrated throughout the day by drinking plenty of water. Staying well-hydrated can help support your metabolism and aid in digestion, both of which are important for weight loss. Aim to drink at least eight glasses of water per day, and consider adding herbal teas or infused water for added flavor and hydration. Common Questions About Ree Drummond Weight Loss Gummy 1. Is the Ree Drummond Weight Loss Gummy suitable for everyone? While the Ree Drummond Weight Loss Gummy is generally safe for most individuals, it may not be suitable for pregnant or nursing women, children, and those with certain medical conditions. It’s always best to consult with your healthcare provider before starting any new supplement to ensure that it is safe for you to use. 2. How long does it take to see results with the Ree Drummond Weight Loss Gummy? Individual results may vary, but many people report seeing changes in their weight within a few weeks of incorporating the gummies into their routine. Consistency is key, so be sure to take the gummies regularly and follow a healthy lifestyle to maximize your results. 3. Are there any side effects associated with the Ree Drummond Weight Loss Gummy? Some individuals may experience mild side effects such as stomach discomfort or digestive issues when first starting the gummies. These side effects are typically temporary and should subside as your body adjusts to the supplement. If you experience any severe or persistent side effects, discontinue use and consult with your healthcare provider. 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