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They're proteins that sit in a reserve mode, waiting to get acted upon by high stress, for instance, high heat. That's why they're called heat shock proteins. When our cells are exposed to heat shock, these proteins are released, and they protect what are called the folding and unfolding of these different proteins inside of a cell. Inside of a cell, when you build a cell, you have proteins that fold on top of each other. Now sometimes they unfold, sometimes they fold, so these heat shock proteins stabilize them. They hold them in place so that they have a little bit more time to recover when exposed to extreme conditions like high heat. References 1) Li Z and Srivastava P. (n.d.). Heat-shock proteins. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/18432918 2) Heat shock proteins - an overview | ScienceDirect Topics. (n.d.). Retrieved from https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/heat-shock-proteins 3) Heat Stress and Cardiovascular, Hormonal, and Heat Shock Proteins in Humans. (2012, March). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3418130/ 4) Selsby JT , et al. (n.d.). Intermittent hyperthermia enhances skeletal muscle regrowth and attenuates oxidative damage following reloading. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/17110516 5) Wei Q , et al. (n.d.). Heme oxygenase-1 induction contributes to renoprotection by G-CSF during rhabdomyolysis-associated acute kidney injury. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/21511696 6) Costa RJ , et al. (n.d.). Heat acclimation responses of an ultra-endurance running group preparing for hot desert-based competition. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/24444197 7) Scoon GS , et al. (n.d.). Effect of post-exercise sauna bathing on the endurance performance of competitive male runners. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/16877041 8) Kukkonen-Harjula K , et al. (n.d.). Haemodynamic and hormonal responses to heat exposure in a Finnish sauna bath. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/2759081 9) Laatikainen T , et al. (n.d.). Response of plasma endorphins, prolactin and catecholamines in women to intense heat in a sauna. - PubMed - NCBI. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/2830109 10) Running enhances neurogenesis, learning, and long-term potentiation in mice. (9, November). 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We'll also discuss potential side effects, from mild nausea to serious conditions. Whether you're navigating diabetes or seeking weight management solutions, this video is packed with essential information. Don't forget to like and share to help others discover the benefits of GLP-1 medications! #GLP1 #DiabetesManagement #WeightLoss #Health #Wellness #Type2Diabetes #Medication ### **What Is a GLP-1 Medication?** GLP-1 medications are drugs that mimic **glucagon-like peptide-1 (GLP-1)**, a hormone that helps regulate blood sugar levels and appetite. These medications are classified as **GLP-1 receptor agonists (GLP-1 RAs)** and are used primarily for **type 2 diabetes and weight management**. ### **What Are GLP-1 Medications Intended to Treat?** GLP-1 medications are FDA-approved for: 1. **Type 2 Diabetes Mellitus (T2DM)** – They improve blood sugar control by enhancing insulin secretion and slowing digestion. 2. **Obesity & Weight Management** – Some GLP-1 drugs are approved for chronic weight management, as they reduce hunger and increase feelings of fullness. 🔹 **Examples of GLP-1 Medications:** - **Semaglutide (Ozempic, Wegovy)** – Used for diabetes (Ozempic) and weight loss (Wegovy). - **Liraglutide (Victoza, Saxenda)** – Victoza for diabetes, Saxenda for weight loss. - **Dulaglutide (Trulicity)** – Primarily for diabetes. - **Tirzepatide (Mounjaro, Zepbound)** – A dual GLP-1/GIP agonist, used for diabetes and weight loss. ### **Adverse Effects of GLP-1 Medications** While these drugs are effective, they can cause several side effects: ✅ **Common Side Effects:** - **Nausea** - **Vomiting** - **Diarrhea or constipation** - **Reduced appetite** ⚠️ **Serious Adverse Effects:** - **Gastroparesis (Delayed Stomach Emptying)** – Can cause severe nausea and bloating. - **Pancreatitis** – Inflammation of the pancreas, which can be life-threatening. - **Gallbladder Disease** – Increased risk of gallstones. - **Thyroid Cancer Risk** – Some studies suggest a potential risk, especially in patients with a family history of **medullary thyroid cancer**. - **Kidney Issues** – Can lead to dehydration and worsen kidney function in some patients. 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