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#diabetes #weightloss #antihungermedicine Weight loss by diabetes drug linked to "anti-hunger" molecule, finds study Researchers from Stanford Medicine and Harvard Medical School have discovered an “anti-hunger” molecule that is produced after vigorous exercise is responsible for the moderate weight loss caused by the diabetes medication metformin. The finding published in the journal Nature Metabolism revealed the critical role the molecule, called lac-phe, plays in metabolism, exercise and appetite which may help to discover a new class of weight loss drugs. Many people with diabetes who are prescribed metformin lose around 2% to 3% of their body weight within the first year of starting the drug. Although this amount of weight loss is modest when compared with the 15% or more often seen by people taking semaglutide drugs, the discoveries that led to those drugs also grew from observations of relatively minor, but reproducible, weight loss in people taking first-generation versions of the medications. “Until now, the way metformin, which is prescribed to control blood sugar levels, also brings about weight loss has been unclear,” said Jonathan Long, PhD, an assistant professor of pathology. “Now we know that it is acting through the same pathway as vigorous exercise to reduce hunger. Understanding how these pathways are controlled may lead to viable strategies to lower body mass and improve health in millions of people.” The researchers observed obese laboratory mice who were given metformin and found increased levels of lac-phe in their blood. They ate less than their peers and lost about 2 grams of body weight during the nine-day experiment. In the study, Long and colleagues analyzed blood plasma samples from people with Type 2 diabetes before and 12 weeks after starting metformin treatment. They found significant increases in lac-phe levels post-metformin. Additionally, among 79 participants in a multi-ethnic atherosclerosis study taking metformin, those on the drug had higher circulating lac-phe levels compared to non-users. Moreover, a statistical analysis of individuals in the atherosclerosis study who experienced weight loss over the study and follow-up period revealed a significant connection between metformin usage, lac-phe production, and weight reduction. “It was nice to confirm our hunch experimentally. The magnitude of effect of metformin on lac-phe production in mice was as great as or greater than what we previously observed with exercise. If you give a mouse metformin at levels comparable to what we prescribe for humans, their lac-phe levels go through the roof and stay high for many hours.” said Long. “These findings suggest there may be a way to optimize oral medications to affect these hunger and energy balance pathways to control body weight, cholesterol and blood pressure. I think what we’re seeing now is just the beginning of new types of weight loss drugs.” Check full updates on Medical Dialogues Also check out - Medical Dialogues Academy, a renowned academic wing of Medical Dialogues - India's premier health and news online portal, proudly presents this comprehensive course tailored for healthcare professionals eager to delve into the realm of medical journalism. 🔗 Enroll Today: https://academy.medicaldialogues.in/courses/certificate-course-in-medical-journalism/ 📚 Explore More With Us: 📌 Medical Content Writing: https://academy.medicaldialogues.in/courses/medical-content-writing/ 📌 Certificate Course in Pharmaceutical Medico-Marketing: https://academy.medicaldialogues.in/courses/certificate-course-in-pharmaceutical-medico-marketing/ Join us on this enlightening journey and become a part of a community pushing the boundaries of healthcare communication and reporting. Get the latest medical and health news at medicaldialogues.in Follow us on Twitter: https://twitter.com/medicaldialogs Facebook: https://www.facebook.com/medicaldialogues/ Instagram: https://www.instagram.com/medicaldialogues LinkedIn: https://www.linkedin.com/company/medical-dialogues Website: https://medicaldialogues.in/

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We talk a lot about attraction on this channel. And many of you say you feel "unattractive". A lot of this can be fixed if we take a look at our diet. So today, we will be talking about how diet affects your appearance. Ever wondered how your diet impacts your skin, hair, and overall appearance? In this video, we dive into the fascinating connection between what you eat and how you look. From glowing skin to shiny hair, discover the foods that can enhance your natural beauty and those that might be holding you back. Join us as we explore the science behind diet and appearance, and learn how to make simple dietary changes that can lead to stunning results. Disclaimer: We are not professional doctors or nutritionists. The information provided in this video is for informational purposes only and should not be considered as medical advice. Always consult with a healthcare professional or a registered dietitian before making any significant changes to your diet or health routine. Your well-being is important, and professional guidance is essential for personalized advice. Credits: Writer: Syazwana Amirah Editor: Caitlin McColl Script Manager: Kelly Soong Voice Over: Amanda Silvera (http://www.youtube.com/amandasilvera ) Animation: Avery (new animator) Youtube Manager: Cindy Cheong DISCLAIMER: This video may contain information that can be triggering to those suffering from eating disorders or who have an unhealthy relationship with food or body image. If you are struggling, we highly advise you to seek help from a qualified mental health professional. REFERENCES Aragno, M., & Mastrocola, R. (2017). Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease. Nutrients, 9(4), 385. https://doi.org/10.3390/nu9040385 Havlíček, J., & Lenochova, P. (2006). The Effect of Meat Consumption on Body Odor Attractiveness. Chemical Senses, 31(8), 747–752. doi.org/10.1093/chemse/bjl017 Monjazeb, S. (2021, December 8). The Effects of Alcohol on Skin. U.S. Dermatology Partners. Retrieved March 1, 2023, from www.usdermatologypartners.com/blog/effects-of-alcohol-on-skin/ Prentice, A. M., & Jebb, S. A. (2003). Fast foods, energy density and obesity: a possible mechanistic link. Obesity Reviews, 4(4), 187–194. doi.org/10.1046/j.1467-789x.2003.00117.x Van Drielen, K., Gunn, D., Noordam, R., Griffiths, C. E., Westendorp, R. G. J., De Craen, A. J. M., & Van Heemst, D. (2015). Disentangling the effects of circulating IGF-1, glucose, and cortisol on features of perceived age. Age, 37(3). doi.org/10.1007/s11357-015-9771-3 Vrcek, I., Ozgur, O., & Nakra, T. (2016). Infraorbital dark circles: A review of the pathogenesis, evaluation and treatment. Journal of Cutaneous and Aesthetic Surgery, 9(2), 65. doi.org/10.4103/0974-2077.184046 Xie, J., Wang, D., Ling, S., Yang, G., Yang, Y., & Chen, W. (2019). High-Salt Diet Causes Sleep Fragmentation in Young Drosophila Through Circadian Rhythm and Dopaminergic Systems. Frontiers in Neuroscience, 13. doi.org/10.3389/fnins.2019.01271