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This mismatch helps explain why blood sugar control can remain elusive despite appropriate insulin use. Excess glucagon ramps up liver glucose output and ketogenesis, creating a more complex hormonal storm than insulin alone can calm. The lecture also explores new therapeutic strategies—including glucagon receptor blockers and GLP-1 agonists—that may help suppress glucagon more effectively. Dr. Bikman urges a shift in perspective: instead of seeing diabetes as just a disease of insulin, it’s time to recognize its bi-hormonal nature and tailor treatment accordingly. Show Notes/References: For complete show notes and references, we invite you to become an Insider subscriber. You’ll enjoy real-time, livestream Metabolic Classroom access which includes live Q&A with Ben after the lecture, ad-free podcast episodes, show notes and references, online Office Hours access, Ben’s Research Review Podcast, and a searchable archive that includes all Metabolic Classroom episodes and Research Reviews. Learn more: https://www.benbikman.com Translation Notes: You can click the gear icon at the bottom of this video to auto-translate captions. For example, to translate into Polish, select Subtitles, choose Auto-Translate, then first choose English, then choose Auto-Translate again, then choose Polish.) In addition, our channel has first access to YouTube’s new, innovative “auto-dubbing” feature. The process currently supports translations from English into many languages, with more to come. Click on the gear icon, then choose “Audio track” to access. #Type1Diabetes, #T1DM, #InsulinResistance, #Glucagon, #RogerUnger, #DiabetesScience, #MetabolicHealth, #BloodSugar, #Ketones, #DiabetesEducation, #InsulinTherapy, #Endocrinology, #DiabeticKetoacidosis, #DiabetesTreatment, #DiabetesResearch, #MetabolicDisorders, #GlucoseControl, #BetaCells, #AlphaCells, #PancreaticHealth #keto #metabolicclassroom #benbikman #drbenbikman Timestamps (approximate): 00:01 – Rethinking the Insulin-Centric Model 01:04 – Dr. Roger Unger and the Bi-Hormonal Hypothesis 03:15 – Glucagon: The Forgotten Hormone 05:17 – Glucagon Physiology and Liver Function 08:23 – Pericrine Regulation in Pancreatic Islets 10:36 – What Goes Wrong in Type 1 Diabetes 12:45 – Glucagon Secretion Without Insulin 13:50 – Glucagon’s Role in Ketogenesis and Protein Breakdown 15:54 – The Limits of Injected Insulin 17:58 – Why Systemic Insulin Misses the Mark 19:10 – Explaining Glucose Variability and High Insulin Needs 21:34 – Clinical Implications of Hyperglucagonemia 23:32 – Muscle Wasting and Amino Acid Shuttling 24:29 – Blocking Glucagon: A Therapeutic Strategy 25:29 – Type 2 Diabetes and Glucagon Resistance 26:21 – Drug Therapies Targeting Glucagon 28:31 – GLP-1 Drugs as Glucagon Suppressors 29:37 – Final Thoughts: A Paradigm Shift in Diabetes Treatment Ben’s favorite yerba maté and fiber supplement: https://ufeelgreat.com/usa/en/c/1BA884 Ben’s favorite meal-replacement shake: https://gethlth.com (discount: BEN10) Ben’s favorite allulose source: https://rxsugar.com (discount: BEN20) Ben’s favorite health check-up for women: https://choosejoi.co/drben15 (discount: DRBEN15) Ben’s favorite health check-up for men: https://blokes.co/drben15 (discount: DRBEN15) Other products Ben likes: https://www.amazon.com/shop/benbikmanphdWeightloss Loseweightfast Fitness Bellyfat Workoutathome Youtubeshorts Shorts Fit Fatloss Apple cider vinegar (ACV) keto gummies have gained popularity in recent years as a convenient and tasty way to incorporate the benefits of both ACV and the ketogenic diet into one easy-to-take supplement. With claims of aiding in weight loss, boosting metabolism, and improving overall health, many people are curious about the safety and effectiveness of these gummies. If you are considering adding ACV keto gummies to your daily routine, it is important to understand whether they are FDA approved, what you need to know about their safety, and how effective they may be in helping you reach your health and wellness goals. FDA Approval of ACV Keto Gummies When it comes to dietary supplements like ACV keto gummies, the Food and Drug Administration (FDA) does not regulate them in the same way as prescription medications. This means that these supplements do not require FDA approval before they are marketed and sold to consumers. However, the FDA does regulate dietary supplements under a different set of regulations, known as the Dietary Supplement Health and Education Act (DSHEA) of 1994. Under DSHEA, supplement manufacturers are responsible for ensuring the safety and labeling of their products, which includes making sure that their products are not adulterated or misbranded. Despite the lack of FDA approval for ACV keto gummies specifically, reputable supplement manufacturers will adhere to FDA guidelines and regulations to ensure the safety and quality of their products. When choosing a brand of ACV keto gummies, look for products that are manufactured in facilities that follow Good Manufacturing Practices (GMP) and have been tested by third-party organizations for purity and potency. It is also important to note that while the FDA does not approve dietary supplements like ACV keto gummies, they do have the authority to take action against supplement manufacturers if their products are found to be unsafe or misbranded. This underscores the importance of doing your research and choosing a reputable brand when selecting a dietary supplement to add to your daily routine. keto gmy bhb keto oprah winfrey justified laboratories bio lyfe keto gummies goketo gummies official website goketo gummies cost Safety Considerations for ACV Keto Gummies While ACV keto gummies can be a convenient way to incorporate the benefits of ACV and the ketogenic diet into your daily routine, it is important to consider the safety implications of taking these supplements regularly. ACV is highly acidic, and consuming it in large quantities or in concentrated forms like gummies can potentially have negative effects on your health. Some potential side effects of consuming ACV keto gummies include digestive issues like upset stomach, nausea, and heartburn. There have also been reports of tooth enamel erosion and damage to the esophagus from the high acidity of ACV. If you have a sensitive stomach or digestive issues, it is best to consult with a healthcare provider before taking ACV keto gummies to ensure that they are safe for you to use. Additionally, if you are currently taking any medications or have underlying health conditions, it is important to speak with your healthcare provider before starting a new dietary supplement like ACV keto gummies. Some medications may interact with the ingredients in these supplements, potentially leading to adverse effects or reduced efficacy of your medication. Effectiveness of ACV Keto Gummies When it comes to the effectiveness of ACV keto gummies in helping with weight loss and overall health, the research is limited and inconclusive. While some studies have shown that ACV may have a positive impact on weight loss and blood sugar control, these studies have typically been small and have not specifically looked at the effects of ACV gummies. It is important to remember that while ACV keto gummies may be a convenient way to supplement your diet, they should not be relied upon as a standalone solution for weight loss or health improvement. A balanced diet, regular exercise, and overall healthy lifestyle habits are key factors in achieving and maintaining a healthy weight and optimal health. Before adding ACV keto gummies to your daily routine, it is recommended to consult with a healthcare provider or nutritionist to determine if they are a good fit for your individual health and wellness goals. They can help you assess your overall diet and lifestyle habits and make recommendations for dietary supplements that may support your health and well-being. 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It is essential to discuss your medical history and any pre-existing cardiovascular conditions with your healthcare provider before starting treatment with semaglutide to ensure your safety and well-being. Gastrointestinal Disturbances Another common adverse effect of semaglutide for weight loss is gastrointestinal disturbances. These may include symptoms such as nausea, vomiting, diarrhea, and constipation. These side effects typically occur during the initial weeks of treatment as your body adjusts to the medication. If you experience severe or persistent gastrointestinal symptoms while taking semaglutide, it is crucial to talk to your healthcare provider. They may be able to adjust your dosage or recommend strategies to help alleviate these side effects. Managing gastrointestinal disturbances while using semaglutide for weight loss may involve making dietary changes, staying hydrated, and taking over-the-counter medications to relieve symptoms. Your healthcare provider can provide guidance on how to address these issues effectively. Hypoglycemia Semaglutide can lower blood sugar levels, potentially leading to a condition called hypoglycemia. Symptoms of hypoglycemia may include shakiness, sweating, confusion, dizziness, and irritability. It is essential to monitor your blood sugar levels regularly while taking semaglutide, especially if you have diabetes or are at risk for hypoglycemia. If you experience symptoms of hypoglycemia while using semaglutide for weight loss, it is crucial to manage your blood sugar levels promptly. Consuming fast-acting carbohydrates such as glucose tablets, juice, or candy can help raise your blood sugar levels quickly and alleviate symptoms. Your healthcare provider can provide you with a personalized plan for managing hypoglycemia while taking semaglutide. It is essential to follow their recommendations closely to prevent serious complications associated with low blood sugar levels. Renal Impairment Individuals with pre-existing renal impairment may be at an increased risk of experiencing adverse effects while using semaglutide for weight loss. The medication is excreted through the kidneys, so impaired renal function can affect its clearance from the body and increase the risk of toxicity. If you have kidney disease or are at risk for renal impairment, it is vital to discuss this with your healthcare provider before starting treatment with semaglutide. They may need to adjust your dosage or monitor your kidney function more closely to ensure the medication is safe for you to use. Your healthcare provider may recommend regular blood tests to assess your kidney function while taking semaglutide. If any signs of renal impairment are detected, they can make appropriate adjustments to your treatment plan to protect your kidney health. Psychiatric Effects Semaglutide may have psychiatric effects on some individuals, including symptoms of depression, anxiety, and mood changes. It is essential to monitor your mental well-being while using this medication and seek help if you experience any concerning psychiatric symptoms. If you have a history of mental health conditions or are at risk for psychiatric effects, it is crucial to discuss this with your healthcare provider before starting treatment with semaglutide. They can provide guidance on how to manage any potential psychiatric side effects and ensure your mental well-being is protected. Your healthcare provider may recommend regular mental health assessments while taking semaglutide to monitor for any signs of psychiatric effects. It is essential to communicate openly with them about your mental health to receive the support and care you need during treatment. In conclusion, while semaglutide can be an effective tool for weight loss, it is essential to be aware of the potential adverse effects it may cause. By staying informed, monitoring your health closely, and working closely with your healthcare provider, you can maximize the benefits of semaglutide for weight loss while minimizing the risks of adverse effects. Remember to report any unusual symptoms or concerns to your healthcare provider promptly to ensure your safety and well-being while using semaglutide for weight loss. 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Ikaria Lean Belly Juice Advanced Superfood Complex contains a variety of components, each with its own potential benefits: * Metabolic Boosters: Ingredients like [mention specific ingredients, e.g., Fucoxanthin] are included to help accelerate metabolism and convert fat into energy. * Digestive Support: Components such as [mention specific ingredients, e.g., Citrus Pectin] aid in digestion, helping to control appetite and reduce cravings. * Antioxidants: The formula includes antioxidants like [mention specific ingredients, e.g., Resveratrol] to combat fatigue and support overall health. * Gut Health: Ingredients like [mention specific ingredients, e.g., Panax Ginseng] promote a healthy gut, which is essential for nutrient absorption and overall well-being. 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Is Ikaria Lean Belly Juice Advanced Superfood Complex Right for You? Before starting any new supplement, it's important to consider your individual health needs and consult with a healthcare professional. Ikaria Lean Belly Juice Advanced Superfood Complex is designed for adults looking to support their weight management and overall wellness goals. However, it's not a substitute for a balanced diet and regular exercise. In conclusion, Ikaria Lean Belly Juice Advanced Superfood Complex offers a comprehensive approach to supporting weight management and overall well-being. With its blend of natural ingredients, it aims to boost metabolism, increase energy, and promote healthy digestion. Remember to consult with a healthcare professional before starting any new supplement. 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Her use of “doctor” or “Dr.” in relation to herself solely refers to that degree. Dr. Gillaspy was a licensed chiropractor in Pennsylvania, but she no longer practices chiropractic in any state and does not see patients. This video is for general informational purposes only. It should not be used to self-diagnose and it is not a substitute for a medical exam, cure, treatment, diagnosis, and prescription or recommendation. It does not create a doctor-patient relationship between Dr. Gillaspy and you. You should not make any change in your health regimen or diet before first consulting a physician and obtaining a medical exam, diagnosis, and recommendation. Always seek the advice of a physician or other qualified health provider with any questions you may have regarding a medical condition. 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