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Given that GLP-1 RAs can increase the risk for thyroid cancer, patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia type 2 should not take these drugs. Gut motility issues. Since one of the primary mechanisms of action for these drugs is to slow down the gut, patients with gastroparesis — diabetic or otherwise — or other gut motility issues should avoid these drugs. Patients with inflammatory bowel disease also should not use GLP-1 RAs. Pancreatitis. These medications can increase the risk for serious pancreatitis on their own, so use in patients who have had pancreatitis already is not recommended. Renal impairment. An eGFR [estimated glomerular filtrationrate] below threshold, typically around 30 mL/min/1.73 m2, excludes GLP-1 RAs for some patients. Be certain to check the threshold for individual medications before prescribing. And finally, pregnancy. 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It's instrumental in combating inflammation and supporting robust gut health, both of which are critical for overall well-being and weight management. The anti-inflammatory properties of these Sumatra Slim Belly Tonic ingredients are truly beneficial. Black Cohosh is included in the Sumatra Slim Belly Tonic ingredients to support hormonal balance and improve overall wellness. Hormonal balance is often overlooked in weight management, making Black Cohosh a valuable part of the Sumatra Slim Belly Tonic ingredients profile. Lutein, one of the lesser-known but equally important Sumatra Slim Belly Tonic ingredients, enhances skin elasticity and fights oxidative stress throughout the body. While primarily known for eye health, its antioxidant properties align with the holistic benefits of the Sumatra Slim Belly Tonic ingredients. Finally, Inulin rounds out the Sumatra Slim Belly Tonic ingredients. 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