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The 2024 Lasker–DeBakey Clinical Medical Research Award has been presented for the discovery of GLP-1 and its application to the treatment of obesity. Lasker winner Svetlana Mojsov, PhD, discusses her role in this innovative discovery and more with JAMA Senior Editor Anne Rentoumis Cappola, MD, ScM. Related Content: Chemistry Matters—From a Putative Peptide to Effective Treatments for Diabetes and Obesity https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.17571?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public Discovery of cGAS as a DNA-Sensing Enzyme That Triggers Inflammation https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.17873?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public GLP-1 for Treating Obesity—Origin, History, and Evolution https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.18000?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public AIDS in Africa—Impact of Research https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2024.18271?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public Podcast was originally published on September 19, 2024. https://edhub.ama-assn.org/jn-learning/audio-player/10.1001/jama.2024.18624?utm_campaign=podcasts&utm_medium=social&utm_source=youtube&utm_content=public --------------------------------------------------------------------------------- Follow JAMA Author Interviews on: Youtube: https://www.youtube.com/playlist?list=PL4VOPuLXRs1dWJCIIu2iOIOWRGUc0nTOU Apple Podcasts: https://podcasts.apple.com/us/podcast/jama-author-interviews-covering/id410339697 Spotify: https://open.spotify.com/show/61HE3v2dmxyg3nsIRAK25C?si=bcbb384405d44b71 Pocket Casts: https://pca.st/DAh2 Your podcast app of choice: https://pod.link/410339697 Website: https://jamanetwork.com/journals/jama/pages/jama-author-interviews --------------------------------------------------------------------------------- For more from JAMA • https://www.jama.com • https://www.facebook.com/JAMAJournal • https://www.twitter.com/JAMA_Current • https://www.linkedin.com/company/jamanetwork Follow the JAMA Network • https://www.jamanetwork.com • http://www.jamanetworkaudio.com • https://www.facebook.com/JAMANetwork • https://www.twitter.com/JAMANetwork • https://www.instagram.com/JAMANetwork • https://www.pinterest.com/JAMANetwork

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In March 2024, it was announced that Medicare recipients now have coverage for Wegovy if they have overweight or obesity and preexisting heart disease. This decision is based on results of the SELECT trial showing that this drug decreased the risk of heart attack and stroke in people with overweight or obesity and heart disease. While this is exciting news, it feels quite strange that these patients still do not have access to meet with a Registered Dietitian. Currently, Medicare only covers Medical Nutrition Therapy (MNT) for Medicare recipients that have diabetes or chronic kidney disease. While Medicare beneficiaries do technically have an intensive behavioral therapy for obesity benefit, this benefit has many restrictions related to where it can be provided and who it must be billed under. So, unfortunately, most dietitians cannot provide this service, and therefore it a very underutilized benefit. In addition, these visits are also shorter than traditional MNT visits. This makes it difficult for the dietitian or other healthcare professional to do a complete assessment, and the overall therapy may be negatively affected by the time restriction. Medicare limits MNT to three hours for the first year and two hours for every subsequent year. With this restriction, a year's worth of dietitians services costs less than a two-week supply of Wegovy. Please contact your representatives to let them know you support the MNT Act. This would let Medicare beneficiaries meet with a dietitians for overweight and obesity as well as many other nutrition-related health conditions.

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In Episode 24 of Podocyte Talk, we dive into three timely studies: 1️⃣ Real-world comparison of SGLT2 inhibitors and GLP-1 receptor agonists in preventing kidney failure 2️⃣ The impact of acute eGFR decline on finerenone’s cardiovascular and renal benefits 3️⃣ How high carbohydrate intake raises mortality risk in maintenance hemodialysis patients Tune in to explore the latest evidence in diabetic kidney disease, treatment durability, and nutrition in dialysis. Check the links in the description for full study access. #Nephrology #SGLT2i #GLP1RA #Finerenone #CKD #Dialysis #CarbohydrateIntake #PodocyteTalk Comparative Effectiveness of Glucagon-Like Peptide-1 Receptor Agonists and Sodium/Glucose Cotransporter 2 Inhibitors in Preventing Chronic Kidney Failure and Mortality in Patients With Type 2 Diabetes and CKD https://www.ajkd.org/article/S0272-6386(25)00831-5/fulltext Analysis of the prespecified FIDELITY pooled patient dataset examined the efficacy and safety of finerenone in patients with an acute change in estimated glomerular filtration rate https://www.kidney-international.org/article/S0085-2538(25)00323-0/fulltext Association of dietary carbohydrate intake with risk of mortality in maintenance hemodialysis patients: a multicenter prospective cohort study https://academic.oup.com/ckj/advance-article/doi/10.1093/ckj/sfaf124/8121404