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In a fascinating conversation with Professor Max Nieuwdorp of the Amsterdam Medical Centre, Dr James McIlroy explores groundbreaking ideas and research surrounding the microbiome, hormones, and their profound impact on metabolic diseases. This insightful dialogue uncovers the remarkable potential of faecal microbiota transplant (FMT) and emerging pharmaceutical strategies in tackling obesity, diabetes, and even cancer. Timestamps: 00:00 Introduction to Professor Max and the Podcast 02:04 Max's Journey into Microbiome Research 05:06 The Power of Fecal Microbiota Transplantation (FMT) 08:11 Microbiome's Role in Obesity and Metabolic Health 10:42 Challenges and Future Directions in Microbiome Research 14:47 Defining Obesity and Its Genetic Factors 18:39 FMT and Its Impact on Various Diseases 23:48 Optimal Diet for a Healthy Microbiome 31:07 The Power of Combining Probiotics 31:36 The GLP-1 Story: A Deep Dive 32:30 Mechanisms and Effects of GLP-1 Drugs 37:26 The Role of Microbiome in Weight Management 39:18 Selecting the Best Donor for FMT 42:27 Impact of Diet on Microbiome and Health 50:17 Future of Microbiome Research and Therapies 56:13 The Power of Hormones: Book Insights   The Journey into Microbiome Research Professor Nieuwdorp's interest in the microbiome began serendipitously during his postdoctoral studies at UCSD. There, he encountered revolutionary ideas, particularly through the work of Jeffrey Gordon, which highlighted the significance of the microbiome long before it became widely acknowledged. An unforgettable early success with FMT on a patient with Clostridium difficile infection set the foundation for his enduring commitment to this field. Over the years, Nieuwdorp has been involved in pivotal studies, evolving his understanding of how microbiome therapies could be used in metabolic diseases and beyond. Understanding FMT and Its Role FMT has shown remarkable efficacy, especially in treating infections like Clostridium difficile. The discussion highlights an astounding 90% cure rate demonstrated in early trials, a feat Nieuwdorp describes as "seminal". Nonetheless, expanding this success to metabolic conditions such as obesity and autoimmune diseases remains a promising, yet ongoing, challenge. The Nexus Between Microbiome and Obesity While the connection between the microbiome and obesity remains a complex issue, Nieuwdorp emphasises how the microbiome's role in weight control is likely more significant over the long term—akin to directing an oil tanker—than as a quick fix. The conversation delves into why the body finds it easier to gain weight than to lose it, considering genetic predispositions and evolutionary pressures. This adaptability of the microbiome, combined with dietary habits, may significantly influence how our bodies metabolise and store energy. Revolutionary Treatments on the Horizon Emerging pharmacological treatments such as GLP-1 agonists are causing waves in medicine. These drugs, alongside the potential of next-generation probiotics, promise to reshape how obesity and associated conditions are treated. Intriguingly, research continues to suggest the microbiome might itself produce GLP-1, hinting at a future where therapies target these microbial mechanisms directly. The Path Forward: Microbiome as a Predictive Tool Professor Nieuwdorp envisions a future where microbiome profiling becomes a standard diagnostic and preventative tool. It has the potential to predict disease susceptibility, allowing for earlier and more personalised interventions. In parallel, the continued development of FMT and its derivatives may revolutionise treatments for a range of conditions, from cancer to metabolic disorders. The Educational Perspective: "The Power of Hormones" In addition to his pioneering research, Nieuwdorp shares insights in his book, The Power of Hormones, presenting a layperson’s guide to understanding hormones across a lifespan. This book interweaves historical narratives with scientific discussion to elucidate how hormones and the microbiome intersect in influencing daily life. This extensive dialogue with Professor Nieuwdorp is a testament to the potential of microbiome science and the exciting horizon that awaits both researchers and patients. As innovations continue, integrating microbiome knowledge with traditional medical interventions could profoundly change how we understand and treat human health.

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Everything you need to know about weight loss medications like Ozempic, Wegovy, and Mounjaro - explained in simple terms. A clear breakdown of how these game-changing GLP-1 medications work in your body, their differences, and what makes them so effective for both weight loss and diabetes management. Want to understand which medication might be right for you and how they help break through metabolic syndrome? Get straight facts about appetite suppression, fat burning, and why Mounjaro's dual-ingredient formula shows enhanced results. Perfect for anyone considering weight loss medications or looking to better understand their current prescription. If you want to see the entire interview click here: Sarah Adkins FNP | Advanced Practice Provider | The Body Engineer by Isaac Medina #1 🏆Award-Winning Fitness Trainer 💪Help busy pros shed 30+lbs in 16 weeks 🔥Guaranteed results or your money back 👇🏼 Start your transformation now - Contact Me:  isaacmedina.silentsalesman.ca/form/MzMzNjQ0MTEyNTg2MjY- Don't miss out on exclusive content and daily motivation:  Instagram: https://www.instagram.com/isaacmedinaofficial/  Facebook: https://www.facebook.com/isaacmedinaofficial  LinkedIn: https://www.linkedin.com/in/isaac-medina-ba341b3a/  Twitter: https://x.com/IsaacMedina71  Shop: https://isaac-medina-shop.myshopify.com/ #WeightLossMedications #OzempicVsMounjaro #MetabolicHealth

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The Most Dangerous DIET SUPPLEMENTS Circulating in the Market that Damage Your LIVER and KIDNEYS | Unhealthy Ingredients in Diet Supplements to Avoid If you've gone to a dietician, you've probably been warned against diet supplements. However, you probably already know that there are healthy and unhealthy ingredients in diet supplements out there. That also means there are tons of unhealthy ingredients in diet supplements to avoid — if you value your health. Healthy diet supplements often involve boosts of protein, green tea, and vitamins. In other words, these supplements are often found in food and are made to help encourage overall health and wellness rather than weight loss in most cases. Unhealthy ingredients in diet supplements are way more common, and they're often are focused on weight loss. In some cases, they're just bad for your wallet and give you the jitters. In other cases, they can end up with a trip to the hospital - or even the morgue. You might wonder how unhealthy or fraudulent diet supplements even make it onto the market. After all, the FDA was made to test out medicines and food, and they wouldn't just turn a blind eye to this stuff, right? Well, not quite. The fact is that diet supplements aren't regulated by the Food and Drug Administration. This is why many dangerous dietary supplements are on the market - and why no one actually seems to notice. So, if you take diet pills or other similar dietary supplements, make sure your supplementation is healthy by taking a look at our list of unhealthy ingredients diet supplements to avoid. Ephedra When it comes to unhealthy ingredients in diet supplements, we might as well start off with one of the few that has been actively banned by the FDA. Ephedra has been linked to a higher risk of heart attack and stroke. Because of multiple deaths, many dietary supplements that had ephedra or ephedra-like ingredients have been investigated and later banned by the FDA. Chaparral Also known as larrea divaricata, larreastat, and Cresote Bush, many people use chaparral supplements as a way to bolster health during bouts of cancer. It's also been known to soothe rashes, and is an active ingredient in many weight loss diet pills. It sounds great, right? There's a reason why chaparral ended up on this list of unhealthy diet supplements: multiple deaths have been linked to the use of chaparral. Symptoms experienced by chaparral users include jaundice and kidney failure. Due to the damage chaparral can unleash on people's livers and kidneys, the FDA advises against using this supplement. Coltsfoot This dandelion-like plant is a favorite among herbalists who use remedies. It's known to reduce symptoms of bronchitis and alleviate coughing. However, it's also a chart topper on many lists of unhealthy ingredients in diet supplements to avoid. As good as it may be for cough relief, Coltsfoot also causes liver and kidney damage. At least one person has been hospitalized from using Coltsfoot in the past, so you might not want to eat this herb. Comfrey Comfrey, when rubbed on certain body parts, gives you a soothing, gentle warmth that can help ease pain and joint issues. It's also been used to help treat menstrual cramps and also smells decently good. However, you shouldn't eat it. Comfrey, when ingested, causes liver damage, kidney damage, and also could be a potential cancer-causer. In terms of unhealthy diet supplements, this one's bad...but only if you actually eat it Aconit Aconite is a plant that goes by a number of different names, including monkshood and wolfsbane. Sellers claim that this dietary supplement could potentially help users with issues arising from gout, inflammation, and joint pain—and to a point, that may be true. However, aconite is called wolfsbane for a reason; it can kill large dogs. In fact, humans who ingest this often will experience nausea, dizziness, heart palpitations, and in larger doses, can easily die as well. Kava Kava This is one of those unhealthy ingredients in diet supplements that should be obvious. People who ingest tea involving kava kava do so in order to alleviate stress. Yes, this is a mind-altering supplement that gives you a "sleepy, content" buzz. However, that's not always good. Too much kava can cause you to fall asleep at the wheel. It also has been linked to liver damage and kidney damage, making it one of the more dangerous supplements on the market. Country Mallow Country Mallow, also known as "silky white mallow," is a pretty common ingredient in a number of weight loss pills. Supplement makers also say that it's great for asthma, bronchitis, and nasal congestion. Much like most other plants on this list, Country Mallow proves that you don't have to be "unnatural" in order to be one of the most unhealthy diet supplements. This plant's ingestion can lead to organ damage, organ failure, sleep disturbances, and death.

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For episode #76 of "The Weekly Bioanalysis", Dom and John talk about the popular topic of GLP-1 Analogues - these series of recent blockbuster drugs with multiple applications, as well as some of their bioanalytical challenges. First, the guys go over a little bit of the mechanism of action of GLP-1's, then some of the rules around them and their initial diabetic treatments. They talk about the structures, and a little bit about how they are being used in weight loss (which, of course, is how these drugs have become so popular in mainstream culture now). Finally, they will discuss some of the resulting supply chain issues and even some of the bioanalytical challenges and what the future of these GLP-1 Analogues might be. It's a jam packed show - really an interesting, fascinating topic the guys enjoy discussing. “The Weekly Bioanalysis” is a podcast dedicated to discussing bioanalytical news, tools and services related to the pharmaceutical, biopharmaceutical and biomarker industries. Every month, KCAS Bio will bring you another 60 minutes (or so) of friendly banter between our two finest Senior Scientific Advisors as they chat over coffee and discuss what they’ve learned about the bioanalytical world the past couple of weeks. “The Weekly Bioanalysis” is brought to you by KCAS Bio. KCAS Bio is a progressive growing contract research organization of well over 250 talented and dedicated individuals with growing operations in Kansas City, Doylestown, PA, and Lyon, France, where we are committed to serving our clients and improving health worldwide. Our experienced scientists provide stand-alone bioanalytical services to the pharmaceutical, biopharmaceutical, animal health and medical device industries.

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New to semaglutide or tirzepatide? Here are our tips for what to expect when you are just getting started. We survived the mountains of Christmas food and Eva let a wardrobe stylist give her closet a full makeover. Kami SW 250, CW 205, GW 150? Eva SW 280, CW 194, GW 170? Eva + Kami are two old-ish moms kids confronting our reasons for being obese while losing weight on semaglutide and tirzepatide, and roasting our past selves. Sarcasm is our happy place. Follow us on Instagram @lessofyoupodcast.  (https://www.instagram.com/lessofyoupodcast/) After a friend (who is a plastic surgeon) talked Eva into starting semaglutide in February of 2023, she lost 70 pounds in 14 months, alternating between long stretches of being stalled at the same weight and consistent but slow weight loss.  With the dream of being considered just overweight and not obese by the BMI calculator, Eva switched to tirzepatide after 14 months to try and reach a goal that still seems just out of reach.   A prolific eater of her feelings, Kami was tired of being uncomfortable and when she heard through a mutual friend how semaglutide had changed Eva’s life, she found a trusted medical weight loss provider and took the first step.  As Kami starts her life on semaglutide, Eva adjusts to a world with less food noise and figures out how to let go of the crippling negative self-talk.  On each episode, we connect on how our lives are changing in real time as semaglutide and tirzepatide help us be smaller people, and try to answer the bigger question for ourselves:  When there’s less of you, what is left? Are you confronting the same challenges? We’d love to hear your story on the Skinny Shot Stories podcast. Get the details at skinnyshotstories.com or send an email to [email protected]. To help others find great resources for GLP-1 medical weight loss programs, our new list of trusted semaglutide and tirzepatide providers is live & updated regularly at http://lessofyou.com/ To learn more about sponsoring this or for details on advertising opportunities on our cosmetic surgery and weight loss podcasts, get our media kit here: https://www.theaxis.io/ads Host: Eva Sheie & Kami Gamlem Assistant Producers: Mary Ellen Clarkson & Hannah Burkhart Engineering: Aron Devereaux and Spencer Clarkson Theme music: Old Grump, Smartface Less of You is a production of The Axis https://www.theaxis.io/

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