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In this episode, Dr. Gandolfo addresses a compelling question from a listener who is curious about the use of GLP-1 drugs, such as Ozempic and Mounjaro, in patients with inflammatory bowel diseases like Crohn's and ulcerative colitis. Dr. Gandolfo provides a comprehensive overview of GLP-1 drugs, explaining how they function as agonists to stimulate insulin secretion and promote weight loss by altering gut motility and suppressing appetite. Delving into the potential implications for patients with inflammatory bowel disease, Dr. Gandolfo explores recent studies suggesting that GLP-1 drugs might be well-tolerated and could even offer benefits in reducing bowel frequency for patients who have undergone colectomy. While these findings are promising, he emphasizes the need for further human studies to confirm these effects. Dr. Gandolfo also addresses common side effects associated with GLP-1 drugs, such as nausea, and reassures listeners about the overall safety of these medications. He highlights the importance of discussing individual risks and benefits with a healthcare provider before starting any new treatment. Referenced in this episode: DDW abstract on safety of GLP-1 drugs with IBD (https://ddw.digitellinc.com/p/s/safety-and-clinical-effectiveness-of-glp1-agonists-in-inflammatory-bowel-disease-patients-6648) Study of GLP-1 drugs and risk of IBD flare (https://pubmed.ncbi.nlm.nih.gov/39438251/) GLP-1 drugs and possible mechanism of benefit in IBD patients (https://pubmed.ncbi.nlm.nih.gov/37081371/) Pilot study using GLP-1 agonist to reduce diarrhea in colectomy patients (https://pubmed.ncbi.nlm.nih.gov/38668926/) Review of mechanism of action of GLP-1 (https://pubmed.ncbi.nlm.nih.gov/29617641/) Be sure to subscribe to The Real GI Doc Show for more insights, and reach out with your questions on social media @realgidoc or leave an audio question for Dr. Gandolfo here (https://www.realgidoc.com/p/submit-a-question/) . Find The Real GI Doc Show on social media, join the newsletter, read Dr. Gandolfo's bio, or ask a question using this link. (https://realgidoc.start.page/) Watch this episode on The Real GI Doc Show YouTube channel! (https://www.youtube.com/@realgidoc)

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Eli Lilly's Battle Against Compound Pharmacies: The Impact on GLP-1 Drug Access In this episode of 'The Downsized,' host Christopher Durham explores the recent developments in the GLP-1 medication market following the end of the drug shortage. The focus is on Eli Lilly's legal actions against compounding pharmacies that provided affordable alternatives during the shortage, impacting millions of patients who depend on these medications for weight loss. Eli Lilly has sent numerous cease-and-desist letters to various pharmacies and telehealth providers, leading to a legal battle. Despite the official end of the shortage, many patients find it challenging to access the more expensive brand-name options. The episode discusses the broader implications for access to these crucial treatments and criticizes the high costs of pharmaceuticals in the U.S., urging for a reformed healthcare system that prioritizes patient access over corporate profits. Viewers are encouraged to engage with the show through comments and live discussions on their experiences and concerns with these changes. REPORT A SHORTAGE: https://cdernextgenportal.fda.gov/publicportal/s/dsm-submission DOWNSIZED WEBSITE: https://thedownsized.org/ JOIN CLUB DOWNSIZED: https://www.youtube.com/@thedownsized/join DOWNSIZED GLP-1 COMPANION PRODUCT STORE: https://thedownsized.org/downsized-store We use Mochi Health: https://joinmochi.com/. Use Laraine’s code for $40 off: QIYGO8. 00:00 Introduction: Power, Profit, and Patients 00:06 The GLP-1 Drug Shortage and Eli Lilly's Response 01:17 Personal Stories and the Impact of GLP-1 Medications 01:55 Eli Lilly's Legal Campaign Against Compounding Pharmacies 04:33 The Ongoing Battle for Affordable Medication 07:12 The Broader Implications for Patients and Healthcare 08:51 Conclusion and Call to Action

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it's often easier to lose weight after you have your lipedema surgery. we find that some patients fail drugs like ozempic and weight loss surgery or are partial responders, however once they have the liposuction for lipedema surgery they find it easier not only to exercise but also normal diet allows them to lose weight as if they didn't have lipedema. every patient is unique and has different results and responses to medications and surgery, but we recommend discussing with your lipedema surgeon prior to planning any weight loss before or after surgery.

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