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The major mechanism of metabolism of the incretins is cleavage by dipeptidyl peptidase 4 (DPP4), an enzyme that is ubiquitously expressed, including in endothelial cells. ▪ Two pharmacological approaches have been taken to enhance the incretin effect in type 2 diabetes. One approach is to administer GLP-1 'analogues' (GLP-1 receptor agonists) that are resistant to cleavage by DPP4. The other approach is to inhibit DPP4 activity. This effectively increases the half-life and therefore the circulating concentrations of the incretins. ▪ In summary, Ingested glucose causes secretion of incretins from GI tract. These ingredients then increase insulin secretion from the pancreas. Anti-diabetic drugs targeting this mechanism are glp1 analogues and dpp4 inhibitors. And in this way, by increasing insulin secretion, the incretins lower blood glucose. Chapters: 0:00 - Insulin Secretion Mechanism 0:42 - Incretin Effect 1:10 - Incretin Hormones 1:26 - Glucagon-like peptide-1 (GLP-1) Hormone 2:19 - Problem in Diabetes 2:35 - GLP-1 analogues and DPP-4 inhibitors 3:24 - Summary of Incretin Effect incretin hormones, incretin effect, incretin effect glp-1, incretin effect explained, incretin effect in diabetes, insulin, diabetes, glucagon like peptide 1, incretin based therapy of diabetes, incretin pathway, incretin and glp-1, glp 1 analogs, dpp4 inhibitors, sitagliptin, vildagliptin, exenatide, liraglutide, oral antidiabetic drugs, mechanism of insulin secretion, insulin secretion, insulin physiology, insulin pharmacology, diabetes mellitus, medicine, pharmacyd by asim ☕ Buy Me A Coffee: https://www.buymeacoffee.com/pharmacyd 💡 Facebook: https://web.facebook.com/pharmacyd0929 For any Queries and Suggestions Email on: [email protected] Disclaimer: "Content is For Informational & Education Purpose Only, Creamed From Various Authentic Books of Pharmacy & Medicine. 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However, the science behind these claims is still up for debate. While some studies have shown that exogenous ketones, which are the main ingredients in Keto Pills, can help increase ketone levels in the blood and promote fat burning, there is limited research on their long-term effects on weight loss and overall health. It’s important to approach these products with caution and consult with a healthcare professional before adding them to your routine. Benefits and Risks of Keto Pills Proponents of Keto Pills claim that they can help boost energy levels, suppress appetite, and improve focus and mental clarity. However, it’s important to note that not everyone will experience these benefits, and some may even experience negative side effects such as digestive issues, headaches, and electrolyte imbalances. Additionally, Keto Pills are not a magic solution for weight loss and should be used in conjunction with a healthy diet and regular exercise routine for best results. It’s also crucial to stay well-hydrated and monitor your ketone levels while taking these supplements to avoid potential complications. How to Choose the Right Keto Pills With so many options on the market, it can be challenging to know which Keto Pills are legitimate and which are scams. To ensure you are choosing a high-quality product, look for supplements that are made by reputable companies with transparent labeling and third-party testing. It’s also essential to read reviews from other customers and consult with a healthcare provider before making a purchase. Remember that everyone’s body is different, and what works for one person may not work for another. It’s essential to listen to your body and pay attention to how you feel while taking Keto Pills. If you experience any negative side effects or are not seeing the desired results, it may be time to reevaluate your supplement regimen and make adjustments as needed. Final Thoughts on Keto Pills by Shark Tank While the idea of a quick fix for weight loss may be appealing, it’s essential to approach products like Keto Pills with caution and skepticism. The claims made by companies promoting these supplements are often exaggerated, and the long-term effects of taking them are still unknown. It’s crucial to do your research, consult with a healthcare professional, and make informed decisions about your health and wellness journey. Ultimately, the best way to achieve lasting weight loss and improve your overall health is through a balanced diet, regular exercise, and lifestyle changes that you can sustain long term. While Keto Pills may provide a temporary boost, they are not a substitute for healthy habits that support your health and well-being in the long run. Make sure to prioritize your health and wellness above all else, and you will be on the right track to success.