Transcript Weight Loss And Fitness Body Yoga Workout HomePfizer on Friday said it would stop developing the twice-daily version of its experimental weight loss pill after obese patients taking the drug lost weight but had trouble tolerating the drug in a mid-stage clinical study. The drugmaker observed high rates of adverse side effects, which were mostly mild and gastrointestinal, among patients. A significant share of patients also stopped taking the drug in the trial."At this time, twice-daily danuglipron formulation will not advance into Phase 3 studies," the company said. But Pfizer said it still plans to release phase two trial data on a once-a-day version of the drug in the first half of 2024, which will "inform a path forward." The pharmaceutical giant will wait to see that data before deciding whether to start a phase three study on the once-daily pill, which Wall Street views as the more competitive form of the treatment. Still, the data on the twice-daily drug is a blow to Pfizer's hopes to win a $10 billion slice of the booming weight loss drug market, which CEO Albert Bourla has said could grow to $90 billion. The company is betting on a successful weight loss pill to help it rebound from plummeting demand for its Covid products and a roughly 40% share price drop this year. But investors have been pessimistic about Pfizer's potential in the weight loss drug space since the company scrapped a different once-daily pill in June and proceeded with the less attractive danuglipron. Now, Friday's data puts Pfizer even further behind the dominant players in the weight loss drug market, Eli Lilly and Novo Nordisk, which are racing to develop more convenient pill versions of their blockbuster weight loss and diabetes injections. Pfizer's phase two trial on its twice-daily pill followed around 600 obese adults who did not have Type 2 diabetes. The trial examined the drug's effect on weight loss after 26 or 32 weeks, at different dosage amounts ranging from 40 milligrams to 200 milligrams. Like Novo Nordisk's Wegovy and Ozempic, Pfizer's pill works by mimicking a hormone produced in the gut called GLP-1, which signals to the brain when a person is full. All dose sizes of Pfizer's pill showed "statistically significant reductions" in body weight ranging from 6.9% to 11.7% at 32 weeks, and from 4.8% to 9.4% at 26 weeks. Meanwhile, patients on a placebo lost 8% to 13% of their body weight at 32 weeks and 5% to 9.5% at 26 weeks, Pfizer said. The company said high rates of adverse events were observed among patients in the study, with up to 73% experiencing nausea, up to 47% vomiting and up to 25% experiencing diarrhea. More than 50% of patients across all dose sizes stopped taking the pill, compared to roughly 40% among those on the placebo, according to Pfizer. No new safety issues were observed, and danuglipron was not associated with increased liver enzymes like Pfizer's other discontinued weight loss pill. All data is taken from the source: http://cnbc.com Article Link: https://www.cnbc.com/2023/12/01/pfizer-to-discontinue-twice-daily-version-of-weight-loss-pill.html #weight #newshour #newstodayheadlines #newstodayfox #newstodayupdate #newstodayworld #Scientists Found Mounjaro Insulin For Obesity Weight Loss Sugar V6 Newsweight loss exercises athome#yoga#weightloss#fitnessroutine#short Get fit and shed those extra kilos with this easy at-home weight loss yoga routine! Perfect for beginners and all fitness levels, these moves will help you burn fat, build strength, and boost flexibility — all from the comfort of your home. No equipment needed! Subscribe for more quick & effective fitness routines! 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All rights reserved. #shortsvideo #lifeinkorea #wegovyjourneyWeight Loss Exercises At Homeyogaweightlossshortsviralfitnessloseweightpreworkout Obesity and weight gain are prevalent issues in today’s society, with millions of people struggling to shed unwanted pounds and achieve their ideal body weight. Thankfully, there are natural weight loss solutions available that can help individuals reach their goals without resorting to extreme or unhealthy measures. Lean Valley Keto is one such product that offers a safe and effective way to lose weight and improve overall health. What is Lean Valley Keto? Lean Valley Keto is a revolutionary weight loss supplement that is designed to help individuals burn fat and lose weight effectively. The supplement is made using natural ingredients that are clinically proven to promote fat burning and support weight loss. By incorporating Lean Valley Keto into their daily routine, individuals can experience increased energy levels, improved metabolism, and a reduction in cravings for unhealthy foods. One of the key ingredients in Lean Valley Keto is BHB (Beta-Hydroxybutyrate), which is a ketone body that is produced by the liver during fasting or when following a ketogenic diet. BHB helps the body enter a state of ketosis, where it burns fat for energy instead of carbohydrates. This can lead to rapid weight loss and improved overall health. Lean Valley Keto also contains other natural ingredients such as green tea extract, apple cider vinegar, and Garcinia Cambogia, which are known for their weight loss benefits. These ingredients work synergistically to help individuals achieve their weight loss goals and improve their overall well-being. How Does Lean Valley Keto Work? When individuals take Lean Valley Keto, the BHB in the supplement helps the body enter a state of ketosis, where it starts burning fat for energy instead of carbohydrates. This leads to rapid weight loss, increased energy levels, and improved overall health. Additionally, the other natural ingredients in the supplement work together to suppress appetite, boost metabolism, and support fat burning. Many individuals struggle with weight loss because their bodies are unable to burn fat effectively. Lean Valley Keto works by addressing this issue and providing the body with the necessary nutrients and ketones to promote fat burning and weight loss. By incorporating Lean Valley Keto into their daily routine, individuals can jumpstart their weight loss journey and achieve their goals more quickly and effectively. Lean Valley Keto is also formulated to help individuals maintain their weight loss results long-term. The supplement helps the body stabilize blood sugar levels, reduce cravings for unhealthy foods, and support overall health and well-being. This makes it easier for individuals to maintain a healthy weight and continue to see improvements in their physical and mental health. Benefits of Using Lean Valley Keto There are numerous benefits to using Lean Valley Keto as a weight loss supplement. One of the main benefits is its ability to promote fat burning and support weight loss. Many individuals struggle with stubborn fat that is difficult to lose, but Lean Valley Keto can help individuals overcome this challenge and achieve their desired body weight. keto plus apple cider vinegar gummies diet keto gummies pro keto gummies ketorganix gummies the best keto gummies for weight loss In addition to weight loss, Lean Valley Keto also offers other health benefits such as increased energy levels, improved metabolism, and reduced cravings for unhealthy foods. This can lead to a healthier lifestyle overall and help individuals feel more confident and happy in their bodies. Another benefit of using Lean Valley Keto is its natural ingredients, which are safe and effective for promoting weight loss. Unlike other weight loss supplements that may contain harmful chemicals or additives, Lean Valley Keto is made using only natural ingredients that have been clinically proven to support weight loss and improve overall health. Conclusion Overall, Lean Valley Keto is a natural weight loss solution that offers numerous benefits for individuals looking to shed unwanted pounds and improve their overall health. The supplement works by promoting fat burning, boosting metabolism, and reducing cravings for unhealthy foods. By incorporating Lean Valley Keto into their daily routine, individuals can jumpstart their weight loss journey and achieve their goals more quickly and effectively. With its natural ingredients and proven effectiveness, Lean Valley Keto is a safe and reliable option for those looking to lose weight and improve their well-being. Remember to consult with a healthcare professional before starting any new weight loss supplement to ensure it is safe for your individual needs and goals. Weightlossmp4GET YOUR CUSTOM KETO DIET 7-DAY PLAN: 👉 https://tinyurl.com/3awc8x9m Your Perfect Diet Quiz: Find Your Ideal Nutrition Plan: 👉 https://tinyurl.com/3awc8x9m There's only one dish here: Keto Doenjang Braised Pork Belly. Would you like to know exactly what to eat to lose fat and get healthy without giving up your favorite foods... I invite you to watch this short video... Perfect diet plan for weight loss Welcome to Keto Diet for Everyone. Keto helps against cravings! | We have compiled the Easy&Healthy Keto Recipes. | Thank you for watching! Don't forget to like and subscribe Keto Diet for Everyone - Keto helps against cravings and click the notification bell to be updated for our future videos! Follow and subscribe to for not missing any. Thanks! #shorts WHAT helps against cravings?