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Trelagliptin is a dipeptidyl peptidase (DPP)-4 inhibitor THERAPEUTIC INDICATION Trelaget (Trelagliptin) is indicated as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus. DOSAGE AND ADMINISTRATION For adults, 100mg of Trelaget (Trelagliptin) is orally administered once a week. Do not break or crush the tablet. CLINICAL PHARMACOLOGY Mechanism of Action Trelagliptin inhibits dipeptidyl-peptidase-4 (DPP-4) activity which inactivates glucagon-like peptide-1 (GLP-1) secreted into blood from the intestine upon stimulation after oral intake of meals, trelagliptin increases the blood concentration of GLP-1 and promotes insulin secretion by the pancreas dependently on glucose concentration. Impaired Renal Function Since blood concentrations of Trelaget (Trelagliptin) may increase due to a delay in the excretions in patients with moderate renal impairment, therefore the 100mg dose is not recommended. 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